Báo cáo khoa học: Metabolism of N-methyl-amide by cytochrome P450s Formation and characterization of highly stable carbinol-amide intermediate pdf

... 2011 FEBS Metabolism of N-methyl-amide by cytochrome P450s Formation and characterization of highly stable carbinol-amide intermediate Lionel Perrin 1,2,3,4 , Nicolas Loiseau 5 , Franc¸ois Andre ´ 3,4 and ... 0.60 Formation and characterization of stable carbinol-amide L. Perrin et al. 2170 FEBS Journal 278 (2011) 2167–2178 ª 2011 The Authors Journal...

Ngày tải lên: 22/03/2014, 16:20

... acceptors such as cyto- chrome c and Nitro Blue Tetrazolium. The molecular mass of PHI was determined to be 10 kDa by SDS/ PAGE, 8.8 kDa by MALDI-TOF spectrometry and 18 kDa by gel-permeation. This finding ... ratio of 1. Asterisks and broken line: data and fitting with PHI/PHO ratio of 2. Fig. 5. Effect of PHI on the flavin fluorescence of the complex PHR– PHO. Dotted line...

Ngày tải lên: 21/02/2014, 00:20

... characterized by a conserved array of 20 cysteines and the absence of His and aromatic amino acids. MT3 contains 68 amino acids with 70% sequence identity to the MT1 and MT2 (MT1 ⁄ 2) isoforms. The ... the isostuctural replacement of Zn(II) with Cd(II), by monitoring the peptide structure and the flexibility of Zn(II) and Cd(II) by NMR spectroscopy. Another interesting...

Ngày tải lên: 16/02/2014, 15:20

... displacement of p-aminophenol and formation of a (alkoxyl)-monosilane. This reac- tion is facilitated by hydrogen bonding between the imidazole nitro- gen of the conserved histidine (His) and the ... (Asn) and serine (Ser) [4,12]. In the active center of silicatein, the hydroxyl group of Ser26 and the imidazole of His165 (catalytic diad) have been shown to play key rol...

Ngày tải lên: 18/02/2014, 16:20

... rounds of positional refinement, fitting, and introduction of water molecules and SO 4 2) , followed by manual fitting of the model by quanta (Accelrys Inc.), led to an R-factor of 19.78% and R free of ... understanding of the generic principle of catalysis for this family of proteases. Results and Discussion Fold of ervatamin-A The overall structure and fold of...

Ngày tải lên: 18/02/2014, 16:20

... binding of the second glucose unit of oligosaccharidic aglycones and also of the initial portion of alkyl-type aglycones. None of the residues investigated interacted with the terminal portion of ... details about the role of different resi- dues of the aglycone-binding site in the stabilization of ES à and the interdependence between the binding of aglycone and the...

Ngày tải lên: 18/02/2014, 17:20

... selection of natural questions. The articles varied in topic, degree of formality and the amount of details; from ”Horror film” and ”Christ- mas worldwide” to ”G-Man (Half-Life)” and ”His- tory of London”. ... were grouped into groups of 5. Each HIT consisted of 5 assignments, and a $0.05 reward was offered for each HIT. QRepHIT required the least amount of design and t...

Ngày tải lên: 20/02/2014, 09:20

... constituent of the Tic motor complex (see below). The present minireview provides a short description of recent advances in the understanding of the chan- nel-, motor- and regulatory components of the ... phenotype can be complemented by overexpression of the other isoform. However, analysis of double knockouts of both Hsp93 homologues did not result in the identification of...

Ngày tải lên: 07/03/2014, 03:20

... this binding. Some of these Fig. 10. Prediction of nucleolin-binding sites in human lactoferrin (hLf). Sequences of the N2 and C2 domains of hLf, bovine lactoferrin (bLf) and human transferrin ... site of the N-terminal lobe of human and bovine lactotransferrins. Importance of the glycan moiety and of the non-covalent interactions between the N- and C-terminal lobes...

Ngày tải lên: 07/03/2014, 15:20

... an active set of translation candidates. Based on the assumption that some of the active candidates and their respective probabili- ties are already correct, we induce new active candi- dates. ... Initialization Let N C be the maximum number of candidates per source word we allow, V e and V f be the target/source vocabulary and r(e) and r(f) the frequency rank of a source/targ...

Ngày tải lên: 16/03/2014, 19:20