Báo cáo khoa học: Regulatory roles of hyaluronan in health and disease ppt
Báo cáo khoa học: Respective roles of the catalytic domains and C-terminal tail peptides in the oligomerization and secretory trafficking of human acetylcholinesterase and butyrylcholinesterase potx
... acetylthiocholine. The rates of hydrolysis of acetylthiocholine and butyrylthiocholine (at 6 mm) by BChE were approximately 14% and 24% of the rate of hydrolysis of acetylthiocholine (at 2 mm) by AChE. In uence ... domain and the C-terminal t peptides contribute to the control of oligomerization and secretion, in a complex interplay. Origin and significance of the di...
Ngày tải lên: 07/03/2014, 03:20
Báo cáo khoa học: New roles of flavoproteins in molecular cell biology: Blue-light active flavoproteins studied by electron paramagnetic resonance pptx
... modification of the cofactor- binding site at the 8a-methyl group and at the linkage of the ribityl side chain. Hence, as a first result, struc- tural information regarding the distance and location of ... [76]: the protein consists of an a ⁄ b-domain and a FAD-binding domain. The binding pocket, which is smaller but deeper than those of CPD photolyases, is strictly hydrophobic...
Ngày tải lên: 16/03/2014, 02:20
Báo cáo khoa học: New roles of flavoproteins in molecular cell biology: Histone demethylase LSD1 and chromatin pot
... branches off in MAO A and B (Fig. 3A). The SWIRM domain is a motif com- monly found in chromatin enzymes and is responsible for protein–protein and DNA–protein interactions [36]. The name of this ... is in agreement with the domain organiza- tion in the first line. The third line shows a summary of the identified linear motifs (after filtering processing taking in account the...
Ngày tải lên: 16/03/2014, 02:20
Báo cáo khoa học: New roles of flavoproteins in molecular cell biology: An unexpected role for quinone reductases as regulators of proteasomal degradation pptx
... protein [21–23]. The 19S caps are involved in recognition of the polyubiquitinated protein substrates, unfolding of the condemned protein [24], removing ubiquitin chains for recycling [25,26] and ... for sensing and binding of intrinsically unfolded proteins such as transcription factors. This mechanism could be probed by combined structure– function analysis of oxidized and r...
Ngày tải lên: 16/03/2014, 02:20
Báo cáo khoa học: A study of microRNAs in silico and in vivo: diagnostic and therapeutic applications in cancer pot
... this context of expanded incidence and growing prevalence, clinical oncology is poised for unprecedented innova- tion. Through harnessing discoveries in disease patho- biology, increasingly propelled ... prevention, diagnosis and treatment [4–6]. Indeed, the epigenetic, genetic and postgenetic cir- cuits restricting cell destiny are becoming increasingly decoded, and their dysfu...
Ngày tải lên: 16/03/2014, 01:20
Báo cáo khoa học: A study of microRNAs in silico and in vivo: bioimaging of microRNA biogenesis and regulation doc
... imaging sys- tems that are used to create a better understanding of the production and function of miRNA in vivo as well as for monitoring the therapeutic potential of miRNAs in cancer. Bioimaging ... factors, including Oct4, c-Myc and Nanog, regulate the expression of primary miRNAs by binding them to the 5¢ terminal regulatory region of the miRNAs that participate in c...
Ngày tải lên: 16/03/2014, 01:20
Báo cáo khoa học: Novel aspects of calmodulin target recognition and activation pptx
... for- mation with fragments of the K + -channel (c) insertion of CaM between two domains of the anthrax exotoxin (d) binding of Ca 2+ ions to only one EF-hand pair and (e) binding of CaM in an extended conformation ... different Ca 2+ -binding motifs are found in pentraxins, annexins and in C 2 domains [36–39]. The C 2 domains consist of about 130 amino acids forming a co...
Ngày tải lên: 17/03/2014, 09:20
Tài liệu Báo cáo khoa học: Critical roles of Asp40 at the haem proximal side of haem-regulated phosphodiesterase from Escherichia coli in redox potential, auto-oxidation and catalytic control doc
... potential of the haem, rate constants o f CO, O 2 and CN b inding to haem, and CD spectra in the Soret region [15–18], suggesting that this residue is critical for maintaining the electronic states of ... protein. Additionally, spin states of the Fe(III), Fe(II) and Fe(II)-CO complexes of Asp40 mutants were similar to those of the wild-type enzyme in that all mutant protei...
Ngày tải lên: 19/02/2014, 16:20
Tài liệu Báo cáo khoa học: Regulatory modes of rod outer segment membrane guanylate cyclase differ in catalytic efficiency and Ca2+-sensitivity ppt
... Analysis of data was performed with ORIGIN 6.1 and SIGMA PLOT 4.2 software. A direct plot of activity vs. [GTP] gave in all cases a sigmoidal curve indicating cooperative substrate binding. In order ... Protein samples were electrophoresed and blotted together with a sample of ROS containing 5 lg(A)or10lg (B) of rhodopsin. GCAPs in these samples were detected by specific anti...
Ngày tải lên: 21/02/2014, 00:20
Báo cáo khoa học: Different roles of two c-tubulin isotypes in the cytoskeleton of the Antarctic ciliate Euplotes focardii Remodelling of interaction surfaces may enhance microtubule nucleation at low temperature doc
... second intron included nucleotides 210–253 in each gene. Excluding introns and stop codons, the c-T1 and c-T2 coding regions were each 1383 bp in length and predicted proteins of 461 amino acids. ... nucleotide-binding pocket of E. focardii c-tubulins are also candidates for adaptive compensation. Amino acid changes adjacent to the T3 loop and within the T5 loop may in uence...
Ngày tải lên: 07/03/2014, 04:20