Báo cáo khoa học: Function and regulation of ABCA1 – membrane meso-domain organization and reorganization pptx

... of regulation by oxygen, it has been the recent analysis of HIF- 1a and HIF-2a protein stability and transactivation potency that have provided the greatest insights into oxygen sensing and regulation. HIF ... in VHL, Maxwell and coworkers demon- strated that VHL –/ – cells expressed increased levels of endogenous HIF-1a and HIF-2a protein [69]. Moreover, the protein...

Ngày tải lên: 20/02/2014, 23:20

... effects of smooth and rough LPSs of E. coli and S. minnesota on the oxidation of native and cross-linked Hb. Because the auto- oxidationofHbhasbeenshowntodependonthepHand the presence of heavy ... presence and absence of EDTA (Fig. 1). The rate of oxidation was increased in the presence of the LPSs of both the smooth and rough E. coli, but the rate of oxidation in...

Ngày tải lên: 08/03/2014, 10:20

... contained 5 lL of SYBR Green PCR Core Kit (Bioke, Leiden, The Netherlands), 3 pmol of each primer (Isogen, De Meern, The Netherlands or Biolegio, Nijmegen, The Netherlands) and 3 lL of cDNA template ... starvation and glucose excess) and Fig. 5 (relief from glucose limitation only). Instead of the antici- pated hierarchical regulation, a diversity of regulation was observed...

Ngày tải lên: 18/02/2014, 06:20

... translates into an expanding range of physiological functions. These roles include control of gene expression, cell cycle regula- tion, apoptosis, metabolism and ageing. The dependence of sirtuin activity on ... will cover the use and efficacy of small molecule inhibitors and activators of sirtuin activ- ity such as sirtinol, splitomicin and resveratrol with particular focus...

Ngày tải lên: 20/02/2014, 01:20

... is a hand built self-contained lexicon: it con- sists of headwords and their definitions for the most familiar 28,000 words of Japanese. Each definition and example sentence has been parsed, and ... ontology. This makes it possible to test the use of similarity and/ or se- mantic class based back-offs for parsing and gen- eration with both symbolic grammars and statisti- cal mo...

Ngày tải lên: 20/02/2014, 12:20

... destina- tions and notices in transportation facilities, names of buildings and shops, explanations at sightseeing spots, and the names and prices of dishes in restau- rants. They are often written ... lot of wrong candidates. Fig- ure 2 shows a typical result of this OCR. Rectangles indicate erroneous candidates, even in background regions. On the other hand , as it identifies...

Ngày tải lên: 20/02/2014, 15:20

... loss of the axial water ligand. The corresponding spectral changes in the Soret band were therefore followed by stopped-flow and rapid-scan techniques, and the observed first-order rate constants of ... structure of erythrocruorin in the light of the chemical sequence and its comparison with myoglobin. Eur. J. Biochem. 19, 4 2–5 0. 17. Steigemann, W. & Weber, E. (1979) Struc...

Ngày tải lên: 20/02/2014, 23:20

... other hand, fiction (F) and FL, a low-quality subset of F. For LPE, we defined a category D consisting of articles from quality broadsheets. Table 1 gives an overview of the categories and the ... frequencies were standardised using z-scores, so that the resulting random variables have a mean of 0 and a variance of 1. The z-scores were rounded 144 Proceedings of EACL...

Ngày tải lên: 22/02/2014, 03:20

... involved in the allosteric regulation of ligand binding affinity in the receptor [86]. Interestingly, the occurrence of in-frame tandem duplication of exons 1 8–2 5 ⁄ 1 8–2 6 in the EGFR gene results ... activation mechanism [85], and also exerts an allosteric control of ligand binding [86]. This is a result of the interaction of the distal segment of the JM, par- ticular...

Ngày tải lên: 06/03/2014, 09:22

... evidence that inclusion of many of these sequences is actively inhibited due to the presence of intrinsic defects [28], the presence of silencer elements [2 9–3 1] or the formation of inhibiting RNA ... (2003) Spectrum of FAN- CA mutations in Italian Fanconi anemia patients: iden- tification of six novel alleles and phenotypic characterization of the S858R variant. Hum Muta...

Ngày tải lên: 06/03/2014, 09:22