Báo cáo khoa học: The lipid translocase, ABCA4: seeing is believing Naomi Laura Pollock and Richard Callaghan ppt

... Whether this is a symptom or a cause of disc ageing and what significance it has in the visual cycle is unclear. The investment in creat- ing the unique lipid composition of the OS discs, and the ... 278 (2011) 3204–3214 ª 2011 The Authors Journal compilation ª 2011 FEBS MINIREVIEW The lipid translocase, ABCA4: seeing is believing Naomi Laura Pollock...

Ngày tải lên: 22/03/2014, 15:21

... Fig. 2 for the other tested alcohols. Statistical quality Although the focus of the mathematical approach is on the ‘leftward shift’, illustrated in Figs 1 and 2, a statisti- cal analysis was performed ... infor- mation on the specificity of binding of particular vs. bulk lipids, the number of their binding sites and the occupancies and the cooperativity of their potent...

Ngày tải lên: 19/02/2014, 18:20

... in the control of gene expression. As each step of the RNA metabolism is tightly regulated, the regulation of mRNA export, stability and transla- tion rate is essential for the control of the ... was isolated and analyzed by northern blot using Fluc and Rluc riboprobes. The radioactive signals were quantified by the STORM 820 equipment and IMAGEQUANT software (Molecul...

Ngày tải lên: 16/02/2014, 15:20

... NTD. This minireview reports on the search and the design of peptides and small organic com- pounds that are able to interact with the CTD and ⁄ or CA of HIV-1. Such molecules aim to disrupt and ... for the whole CA has the sequence IPVGEIYKRW, which corresponds to the a-helix 7 of NTD. This region is important for the formation of CA hexamers [6]; there- fore, this pe...

Ngày tải lên: 18/02/2014, 06:20

... ana- lyzed the expression of Sox9 in these tissue sections, and found Sox9 expression in the osteoarthritic carti- lage (Fig. 3F). AP-2a and Sox9 activate the AP-2e promoter To obtain insights into the ... differentiation. AP-2a is essential for skeletal development, and is expressed in limb buds during early embryogenesis, in the growth plate, and in chondrocytes of th...

Ngày tải lên: 18/02/2014, 08:20

... cellulose [14]. The enzyme diversity they contain and their heter- ogeneous composition are inherent characteristics of cellulosomes. Our data suggest that these characteristics give rise to synergistic ... proteins 9, 12 and 14 in fraction F1 is consis- tent with the high xylanase activity seen in this fraction. However, GH10 (protein 12) is also present in noticeable quantities...

Ngày tải lên: 18/02/2014, 08:20

... holding them. Then we will look at the motion o f the person and his keys after he lets go of them. Let's begin by looking at the motion of the man an d his keys while he is holding them. ... between the ratings of the NM problem and the noNM problem (i.e. the NM is disabled). Table 1 lists the 16 questions in the question- naire order. The table shows f...

Ngày tải lên: 20/02/2014, 12:20

... in the BAP31 immunopre- cipitate, indicate that the association between BAP31 and c-actin was the result of specific interactions. Discussion We describe in this paper the purification and the ... LC-lESI-MS/MS. Detailed analysis of the 28-kDa protein confirmed its identity as the endogenous BAP31 protein while the 42 and the 190 kDa bands were identified as nonmuscle c-ac...

Ngày tải lên: 20/02/2014, 23:20

... demonstrated that Unkempt is primarily localized in the cytoplasmic compartment, but has the ability to shuttle between the nucleus and the cytoplasm, suggesting that the Rac- and Unkempt-dependent ... between the nucleus and the cytoplasm and can therefore reach its putative substrate BAF60b in the nuclear compart- ment. Interestingly in this regard, several studies...

Ngày tải lên: 06/03/2014, 09:22

... important. One of these, the TRP sequence, includes the start of the C-terminal helix as well as the structured loop between the ATPase domain and the C-terminal helix and in the 3D structure is positioned ... helix). However, the majority of these proteins are likely to be other meiotic clade AAA ATPases and have the AAA domain helix and the C-terminal helix, bu...

Ngày tải lên: 07/03/2014, 05:20