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Báo cáo Y học: A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor pot

Báo cáo Y học: A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor pot

Báo cáo Y học: A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor pot

... functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor Andreas Timmermann, Andrea Ku¨ ster, Ingo ... constitutively associates with tyrosine kinases of the Janus kinase (Jak) family. Upon ligand binding the associated Jaks become activated by transphosphorylationand phosphorylate tyrosine residues in the ... single domain in the membrane-proximal part of gp130 leads to a shift of the receptor areas involved in ligandbinding closer to the membrane, resulting in the inability of the receptor chains...
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Báo cáo Y học: A critical motif for oligomerization and chaperone activity of bacterial a-heat shock proteins pot

Báo cáo Y học: A critical motif for oligomerization and chaperone activity of bacterial a-heat shock proteins pot

... coelute with the His6-tagged a- crystallin domain (Fig. 6A) , suggesting that the isolated a- crystallin domain was unable to dimerize. The a- crys-tallin domain carrying the C-terminal extension appearedto ... the presence of a central a- crystallin domain, flanked by a N-terminal region and a C-terminal extension [23]. The highest degree of amino-acid similarity is found within the a- crystallin domain, while the ... [34], as well as spinlabeling studies with aA-crystallin and Hsp27 [45] indicatethat the dimeric building block of many a- Hsp proteins isformed by interacting bstrands in the a- crystallin domain.Although...
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Báo cáo Y học: A new conceptual framework for enzyme catalysis Hydrogen tunneling coupled to enzyme dynamics in flavoprotein and quinoprotein enzymes docx

Báo cáo Y học: A new conceptual framework for enzyme catalysis Hydrogen tunneling coupled to enzyme dynamics in flavoprotein and quinoprotein enzymes docx

... tunneling has beeninvoked in the reappraisal of the catalytic mechanism of the aspartate proteinase family of enzymes [30]. Our own work,and that of others, on the link between dynamics andtunneling ... 100-fold in a H172Q mutantTMADH [44], and by an additional factor of 4 in a Y1 69Fmutant TMADH [43]. Both His172 and Tyr169 are locatednear the substrate-binding site and the flavin isoalloxazinering ... breakage in dopamine,tryptamine and benzylamine, and the relative KIEs, giveimportant insight into the shape of the potential energybarrier separating reactants from products. Although a fluctuating...
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Báo cáo y học:

Báo cáo y học: " A retrospective quality assessment of pre-hospital emergency medical documentation in motor vehicle accidents in south-eastern Norway"

... drafting, revising, and final approval of the manuscript.SS was involved in the study conception and design, data analysis, and in the revising and final approval of the manuscript.Competing interestsTS ... Recommendations for uniform reporting of datafollowing major trauma the Utstein style. A report of a working party of the International Trauma Anaesthesia and Critical Care Society (ITACCS).Resuscitation ... Pre-hospital airway management: guidelines from a task force from the Scandinavian Society for Anaesthesiology and Intensive Care Medicine.Acta Anaesthesiol Scand 2008, 52:897-907.5. Gaarder C, Naess...
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Báo cáo y học:

Báo cáo y học: "A prospective observational study of the relationship of critical illness associated hyperglycaemia in medical ICU patients and subsequent development of type 2 diabetes"

... whereinflammation probably plays a minor role and sepsiswhere systemic inflammation is an important contribut-ing factor. The difference in the incidence of hyperglycae-mia is probably a consequence ... and septic shockb ACS, acute coronary syndrome (unstable angina and myocardial infarctionFigure 2 Cumulative incidence of diabetes in patients with hy-perglycaemia and normoglycaemia during ... fortendency to hyperglycaemia that are the root of hospitalacquired hyperglycaemia and in the long term lead todevelopment of diabetes.Although the incidence of hospital acquired hypergly-caemia...
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Báo cáo y học:

Báo cáo y học: "A three-country comparison of psychotropic medication prevalence in youth"

... 1Pharmaceutical Health Services Research, School of Pharmacy, University of Maryland, Baltimore, Maryland, USA, 2Department of Psychiatry, School of Medicine, University of Maryland, Baltimore, ... Maryland, USA, 3Departments of Psychiatry and Pediatrics, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA, 4Department of Social Pharmacy, Pharmacoepidemiology & Pharmacotherapy, ... of about 270 dif-ferent statutory health insurance companies in Germany.Nearly 90% of the 82 million German inhabitants aremembers of a statutory health insurance company.Although many such...
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Báo cáo y học:

Báo cáo y học: "A Comparison of Immuncapture Agglutination and ELISA Methods in Serological Diagnosis of Brucellosis"

... Medical Microbiology Laboratory, Karaman State Hospital, Karaman, Turkey 3. Medical Microbiology Laboratory, Batman State Hospital, Batman,Turkey 4. Medical Microbiology Laboratory, Konya Education ... temperature, sweating and pain in the joints but it is also a disease that leads to clinical pictures imitating rheumatic and psychiatric diseases. Brucella is a gram negative staining, immotile, ... of the other two methods were calculated and their compatibility with one another was investigated statistically. In a comparative study conducted by Prado et al (6), immuncapture agglutination...
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Báo cáo y học:

Báo cáo y học: "A Comparative Effectiveness Study of Bone Density Changes in Women Over 40 Following Three Bone Health Plans Containing Variations of the Same Novel Plant-sourced Calcium"

... Kaats holds equity in Integrative Health Technologies, Inc., a public company which holds a minority of shares in the grantor company. All other authors declare that they had no competing interests. ... the study also provides evidence of the benefit of adding the physi-cal activity and health literacy components, the data also support the efficacy of plant-source calcium as a stand-alone ... and absence of heavy minerals and other contaminating ingredients. Calcium, magnesium and other minerals were validated by Advanced Labs, Salt Lake City, UT. The supplement provided to all...
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Báo cáo y học:

Báo cáo y học: "A severe coarctation of aorta in a 52-year-old male: a case report"

... Ivyspring International Publisher. All rights reserved Case Report A severe coarctation of aorta in a 52-year-old male: a case report Davran Cicek1, Cevahir Haberal2, Suleyman Ozkan3, ... significance of the cardiac dysfunction and his clinical presentation, the patient underwent a cardiac catheterization to evaluate his coronary artery dis-ease. The left ventricular ejection fraction ... Turkey  Corresponding author: Dr. Davran Çiçek, Başkent University School of Medicine, Department of Cardiology, Saray Mah. Yunusemre Cad., No:1 07400 Alanya, Antalya, Turkey. Telephone: 90 532...
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Báo cáo y học:

Báo cáo y học: "A case of mistaken identity: Asystole causing convulsions identified using implantable loop recorder"

... resolution of her TLOC ep-isodes. This case graphically illustrates the utility of the ILR in establishing the cause of recurrent unexplained TLOC. In addition the tracing demonstrates an inter-esting ... Fitzpatrick AP. Misdiagnosis of epilepsy: many seizure-like attacks have a car-diovascular cause. J Am Coll Cardiol. 2000;36(1):181-4 2. Kanjwal K, Kanjwal Y, Beverly K, Grubb BP. Clinical Symptoms ... convulsive activity lasting from 1-5 minutes associated with urinary in- continence. The loss of consciousness could last for 30 to 45 minutes. Afterwards the patient was confused and fatigued for the...
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