Báo cáo Y học: The reductive hotspot hypothesis of mammalian aging Membrane metabolism magnifies mutant mitochondrial mischief pptx
Báo cáo Y học: The reductive hotspot hypothesis of mammalian aging Membrane metabolism magnifies mutant mitochondrial mischief pptx
... MINIREVIEW The reductive hotspot hypothesis of mammalian aging Membrane metabolism magnifies mutant mitochondrial mischief Aubrey D. N. J. de Grey Department of Genetics, University of Cambridge, ... unattractively elaborate, the reductive hotspot hypothesis of mammalian aging is an extension of the long-standing mitochondrial theory that, unli...
Ngày tải lên: 17/03/2014, 23:20
Báo cáo Y học: The C-terminal domain of perfringolysin O is an essential cholesterol-binding unit targeting to cholesterol-rich microdomains pptx
... X-ray crystallography, supporting the idea that biosynthesized domain 4 automatically folds into the secondary structure of the native toxin. On the other hand, the spectra of the T2 and T2¢ fragments ... compartments in the endo- cytic pathway [14]. In a further study on lipid rafts, analysis of the dynamic movement of intracellular rafts, for instance raft assembly a...
Ngày tải lên: 23/03/2014, 21:20
Báo cáo Y học: The cold-active lipase of Pseudomonas fragi Heterologous expression, biochemical characterization and molecular modeling pdf
... flexibility and ability of interaction with the solvent [3]. Both factors are of importance for cold activity. On the other hand, the presence of disulphide bridges may increase the rigidity of the ... in the fraction of soluble lipase. The apparent ineffectiveness of foldase together with the lack of a signal peptide at the N-terminal suggests the hypothesis...
Ngày tải lên: 24/03/2014, 04:21
Báo cáo Y học: The cytoplasmic C-terminus of the sulfonylurea receptor is important for KATP channel function but is not key for complex assembly or trafficking pdf
... persistent hyperinsulinaemic hypoglycaemia of infancy [12] cluster in this domain of the protein. Persistent hyperinsulinaemic hypoglycaemia of infancy is an hereditary disease char- acterized by inappropriately high ... simultaneous masking of these two signals by interaction of the two proteins allows the channel complex to proceed through the biosynthetic pathway to the...
Ngày tải lên: 31/03/2014, 08:20
Báo cáo Y học: The C-terminal region of ammodytoxins is important but not sufficient for neurotoxicity pot
... specific binding sites (receptors) on the presynaptic membrane [6], after which they are presumably endocytosed. In the nerve cell, they may inhibit the recycling of synaptic vesicles by binding to certain target ... 3.1.1.4) constitute a diverse superfamily of enzymes that catalyze the hydrolysis of the sn-2 ester bond of phospholipids. They are divided into intracellular...
Ngày tải lên: 31/03/2014, 08:20
Báo cáo Y học: The processivity and fidelity of DNA synthesis exhibited by the reverse transcriptase of bovine leukemia virus pot
... analysis of the processivity and the fidelity of DNA synthesis (namely, the ability of BLV RT to misincorporate nucleotides at the 3¢ end of the growing DNA strand and the further extending of the ... Virology 259, 176–189]. In the p resent study, we have studied in vitro two features of the DNA polymerase activity of BLV RT, t he processivity of DNA synthesis...
Ngày tải lên: 31/03/2014, 21:21
Báo cáo y học: "The Systemic Inflammatory Response Syndrome (SIRS) in acutely hospitalised medical patients: a cohort study"
... and they would be missed if SIRS were used as the only way to identify infected patients. If the main pur- pose was to identify patients with a high risk of mortality, the question is whether ... identified by two or more symptoms including fever or hypothermia, tachycardia, tachypnoea and change in blood leucocyte count. The relationship between SIRS symptoms and morbidity and mort...
Ngày tải lên: 25/10/2012, 09:56
Báo cáo y học: "The epidemiology of medical emergency contacts outside hospitals in Norway - a prospective population based study"
... Together with the complete set of AMIS forms, this yields a comprehen- sive material for analysis of the objectives of the study. There are some limitations of the study. Severity score (NACA) ... proportion of 45% (table 4). A29 “Breathing difficulties” was the most used Index- category in the “all other” group with nearly 5% of the total. Approximately half of al...
Ngày tải lên: 25/10/2012, 09:56
Báo cáo y học: "A prospective observational study of the relationship of critical illness associated hyperglycaemia in medical ICU patients and subsequent development of type 2 diabetes"
... commonly complicated by hyperglycaemia caused by mediators of stress and inflammation. Severity of disease is the main risk factor for development of hyperglycaemia, but not all severely ill ... for tendency to hyperglycaemia that are the root of hospital acquired hyperglycaemia and in the long term lead to development of diabetes. Although the incidence of hospital acqui...
Ngày tải lên: 25/10/2012, 10:02
Báo cáo y học: "The evolving story of medical emergency teams in quality improvement"
... observations that, in the majority of patients, premonitory signs and symptoms of cardio- pulmonary instability are often present hours before clinical deterioration [6]. By encouraging early responses ... rates of adverse events [4,5]. All of these detection methods require substantial investments of time and money. Moreover, especially in the case of chart review, missing in...
Ngày tải lên: 25/10/2012, 10:06