Báo cáo Y học: Mitochondrial DNA deletion mutations A causal role in sarcopenia docx
Báo cáo Y học: Mitochondrial DNA deletion mutations A causal role in sarcopenia docx
... MINIREVIEW Mitochondrial DNA deletion mutations A causal role in sarcopenia Debbie McKenzie, Entela Bua, Susan McKiernan, Zhengjin Cao, Jonathan Wanagat and Judd M. Aiken Department of Animal ... accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc. Natl Acad. Sci. USA 89, 7370–7374. 24. Katayama, M., Tanaka, M., Yamamoto, H., Ohbaya...
Ngày tải lên: 17/03/2014, 23:20
Báo cáo khoa học: Transmembrane helix 12 plays a pivotal role in coupling energy provision and drug binding in ABCB1 pot
... ATP hydrolytic cycle in ABCB1 and, in particular, in coordinating conformational changes between the NBDs and transmembrane domains. Abbreviations ABC, ATP-binding cassette; AMP-PNP, 5¢-adenylylimidodiphosphate; ... followed by a 20 min incubation at 20 °C. Trapping of ABCB1 in the posthydrolytic state was achieved by the addition of 300 l m orthovanadate (V i ) and 2 mm ATP, follow...
Ngày tải lên: 06/03/2014, 22:21
Báo cáo khoa học: Acylation of lysophosphatidylcholine plays a key role in the response of monocytes to lipopolysaccharide ppt
... species carrying polyunsaturated fatty acids [13]. It has recently been shown that PKC was activated only by 1,2-DAG carrying polyunsaturated fatty acids in activated T-cells [14]. In support ... IL-6, interleukin-6; LPS, lipopolysaccharide; LPAAT, lysophosphatidate acyltransferase; LPCAT, lysophospha- tidylcholine acyltransferase; NASBA TM , nucleic acid sequence based amplification; ......
Ngày tải lên: 31/03/2014, 01:20
Báo cáo y học: "HIV DNA and Dementia in Treatment-Naïve HIV-1-Infected Individuals in Bangkok, Thailand"
... HIV DNA in PBMC as a risk for HAD in HAART-experienced individuals; and preliminary analyses suggest that the majority of this HIV DNA may be in circulating M/MФ [15]. We demonstrated that ... underlying mechanisms to explain the continued prevalence of HAD in the era of HAART. Since HIV DNA in M/MФ persists while individuals are on HAART and since monocytes likely p...
Ngày tải lên: 31/10/2012, 15:34
Tài liệu Báo cáo Y học: BIGH3 (TGFBI) Arg124 mutations influence the amyloid conversion of related peptides in vitro Implications in the BIGH3-linked corneal dystrophies pptx
... variant of granular corneal dystrophy type 1 (GCD1), Arg124His (R124H) [1] in granular corneal dystrophy type 2 (GCD2, Avellino dystrophy) a mixed type of amyloid and granular deposits, and Arg124Leu ... protein with an amino-terminal secretory sequence, a carboxy- terminal Arg-Gly-Asp sequence and four homologous domains of 140 amino acids [2]. The TGFBI protein, as other homologous pr...
Ngày tải lên: 21/02/2014, 01:21
Báo cáo Y học: Introducing Wilson disease mutations into the zinc-transporting P-type ATPase ofEscherichia coli The mutation P634L in theÔhingeÕ motif (GDGXNDXP) perturbs the formation of the E2P state pdf
... phosphorylated aspartate in th e P domain. The motif CPX is an intramembraneous metal binding site present in all heavy metal transporting P-type ATPases (X ¼ C,H,S). The location of the domains and ... CG-3¢ Fragment 2 Forward: 5¢-CGC GAC GCA TCT ACT GGC GCA AG-3¢ Reverse: 5¢-CCC ATA TGG TAC CCC TTA TCT CCT GCG-3¢ Asp628Ala Fragment 1 Forward: 5¢-TAA AAC CGG TAC GT T AAC CGT CGG TAA ACC...
Ngày tải lên: 17/03/2014, 17:20
Báo cáo Y học: The DNA-polymerase inhibiting activity of poly(b-L-malic acid) in nuclear extract during the cell cycle of Physarum polycephalum pot
... other DNA polymerases in the extract. Standard DNA polymerase activity and inhibition assays Total DNA polymerase activity was assayed as described previously [12]. The standard assay contained in ... testis DNA for the s tandard DNA polymerase a ssay and for photoaffinity labeling was prepared as described previously [12]. Rabbit antiserum against DNA polymerases type a an...
Ngày tải lên: 31/03/2014, 21:21
Báo cáo y học: "Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections"
... improves clinical decision making and adds timely information beyond that of readily available information from clinical examination. Observational studies alone cannot provide such information, but may ... biologic plausibility and availability [8-25]. We measured PCT and proADM as markers of bacterial infection and inflamma- tion; the atrial-natriuretic peptide proANP and proET-1 as markers...
Ngày tải lên: 25/10/2012, 10:02
Báo cáo y học: "The evolving story of medical emergency teams in quality improvement"
... requiring substantial investments of additional resources. Academic centers are increasingly recognizing engagement in quality improvement as a distinct career pathway. Involving such physicians in ... the standardized MET form on each patient and a weekly 1-hour Commentary The evolving story of medical emergency teams in quality improvement André Carlos Kajdacsy-Balla Amaral 1 and...
Ngày tải lên: 25/10/2012, 10:06
Báo cáo y học: "Trace Elements, Heavy Metals and Vitamin Levels in Patients with Coronary Artery Diseas"
... lead concentrations may be increased in patients with CAD. Key words: coronary artery disease; trace element; heavy metal; vitamin INTRODUCTION Coronary artery disease (CAD) is a leading cause ... Research Paper Trace Elements, Heavy Metals and Vitamin Levels in Patients with Coronary Artery Disease Aysegul Cebi 1 , Yuksel Kaya 2 , Hasan Gungor 3 , Halit Demir 4 , Ibrahim Hakk...
Ngày tải lên: 25/10/2012, 10:51