... derived from the amyloid precursorprotein by sequential proteolytic cleavage by twomembrane-bound proteases, b- and c-secretase [2].The length of the peptide is variable, ranging from 39KeywordsAlzheimer’s; ... cleaved by a-secretase to generate thenon-amyloidogenic sAPPa and p3 fragments from amyloid precursor protein, precluding the productionof Ab [43,44]. The p3 peptide and Ab differ by onlythe ... strongattraction between the peptide backbone and chargedresidues draws the headgroups of nearby lipids away from other surrounding lipids, pulling the entire lipidmore parallel to the surface of...