... recovered, only the longest amino acid sequences that included the DNA binding, hinge and ligand-binding domains were used for this analysis, except for the Knirps fam- ily members that lack the LBD. In D. ... vitellogenic female mosquitoes. They isolated several clones that code for a single protein. Interestingly, during the initial process of identifying the NR family members...
Ngày tải lên: 18/02/2014, 13:20
... interpretation in distinguish- ing interacting from noninteracting proteins. One Fig. 1. Schematics of library designs. The helical wheel diagram looks down the axis from the N-terminus to the C-terminus. ... focused on small molecule inhibitors, but the potential of using peptides as the starting point in the generation of therapeutics is now a growing area [18,19]. Peptide...
Ngày tải lên: 18/02/2014, 13:20
Tài liệu Báo cáo khoa học: Final steps in the catabolism of nicotine Deamination versus demethylation of c-N-methylaminobutyrate doc
... lead to the complete mineraliza- tion of the pyrrolidine ring of nicotine, which after oxidation by 6-hydroxy-l-nicotine oxidase, is cleaved off from the pyridine ring of nicotine in the form ... enzymes involved in nicotine catabolism will have applications not only in the bioremediation of nicotine waste, but also in the supply of nicotine derivatives as starting materia...
Ngày tải lên: 19/02/2014, 07:20
Tài liệu Báo cáo khoa học: Isochore structures in the chicken genome ppt
... computing the G + C content in sliding windows moving along the genome. Fig. 4. The negative cumulative GC profile for GGA12 marked with the segmentation points obtained. The bottom five plots show the ... all the seg- ments obtained at t 0 ¼ 100 without the constraint of the minimum length in the draft genome sequence of chicken. (A) The length dis- tribution of all...
Ngày tải lên: 19/02/2014, 07:20
Tài liệu Báo cáo khoa học: Oxidative stress in the hippocampus after pilocarpineinduced status epilepticus in Wistar rats doc
... in epileptic patients [27]. Other mechanisms may be associated with the increase in ROS levels in the epilepsy model as well as in neurodegeneration observed in epileptic humans [18,28]. During ... findings show that pilocarpine induces SE, which can produce alterations in superoxide dismutase and catalase activities in different areas, thereby pro- tecting the brain from n...
Ngày tải lên: 19/02/2014, 16:20
Tài liệu Báo cáo khoa học: Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181 and His184 pdf
... productive binding of steroid substrates: in the first, a (small) sub population of enzyme binds directly the steroid in the reactive conformation, with the remainder of the enzyme binding the unreactive conformation. ... unusual in having two histidine residues (rather than the His-Asn pair seen in OYE, MR and some of the other member proteins; Fig. 1B) in the acti...
Ngày tải lên: 20/02/2014, 02:21
Tài liệu Báo cáo khoa học: Proteasome involvement in the degradation of the Gq family of Ga subunits pptx
... lCiÆmL )1 [ 3 H]inositol for 24 h in inositol-free medium containing 10% (v ⁄ v) dialyzed fetal bovine serum. Cells were then washed and incubated in NaCl ⁄ P i containing 20 mm Li + with the agonist ... RGS domain in the amino-terminus of G protein-coupled receptor kinase 2 inhibits Gq-mediated signaling. Int J Mol Med 5, 335–340. 20 Chen CA & Manning DR (2001) Regulation of G...
Ngày tải lên: 20/02/2014, 03:20
Tài liệu Báo cáo khoa học: Inorganic pyrophosphatase in the roundworm Ascaris and its role in the development and molting process of the larval stage parasites doc
... determined by incubating the diluted recombin- ant proteins in the standard reaction mixture in the presence of increasing concentrations of PP i (0.05–0.5 m M )at55°C. Data were fit to the appropriate ... rate was then calculated. Larval molting inhibition assay To confirm whether the native PPase enzyme is involved in the molting process, we examined the effects of two PPa...
Ngày tải lên: 20/02/2014, 11:20
Tài liệu Báo cáo khoa học: "Multimodal Generation in the COMIC Dialogue System" docx
... used in bathroom sales situa- tions to help clients redesign their rooms. The input to the system includes speech, handwriting, and pen gestures; the output combines synthesised speech, a talking ... control of the underlying applica- tion. Figure 1 shows screen shots of the COMIC interface. There are four main phases in the demonstra- tor. First, the user specifies the sha...
Ngày tải lên: 20/02/2014, 15:20
Tài liệu Báo cáo khoa học: Adaptive changes in the expression of nuclear and mitochondrial encoded subunits of cytochrome c oxidase and the catalytic activity during hypoxia pptx
... lgÆmL )1 penicillin/streptomycin. The myocytes were induced to differentiate into myoblasts by replacing the medium at confluence with a fresh medium containing 2% (v/v) fetal bovine serum. These myoblasts ... during hypoxia. In the absence of differential regulation of a specific nuclear gene coding for the subunits of CytOX, changes in the microenvironment of the cell may indu...
Ngày tải lên: 20/02/2014, 23:20