... [3].
TRPM4b is a member of the family of melastatin-
related transmembrane receptor potential channels. The
eight members of this family differ largely in their ion
selectivity and mode of activation [4]. ... Fig. 2A,B).
Generation of HEK-293 clones with stable
expression of TRPM4b
To investigate the effect of TRPM4b expression on
Ca
2+
entry and changes of the transmembra...
...
support queries of this
type.
The second type of query asks about the
state -of- the-world on a given date (Query 4) or
during an interval of time (Query 5). Understanding
and answering these queries ... variety of
temporal queries. Based on this analysis, a
computational model is described that satisfies many
of the requirements for understanding and answering
time...
... of InsP
6
to PhyAsr (Table 1). Given the absence
of structural changes as a function of ionic strength and
ligand binding, the effect of ionic strength on catalytic
activity is probably not of ... move-
ment of the P-loop in PhyAsr is due to oxidation of
the catalytic cysteine, we oxidized crystals of PhyAsr
Table 1. Effect of ionic strength on the hydrolysis of InsP
6
b...
... Sedla
´
c
ˇ
ek
3
and Jindr
ˇ
ich Has
ˇ
ek
1
1
Institute of Macromolecular Chemistry,
2
Institute of Organic Chemistry and Biochemistry and
3
Institute of Molecular Genetics,
Academy of Sciences of the ... alternative
positions of phenylalanine rings a re formed in concert with
the alternative positions of S
d
and C
c
of Met46 and Met146
(from neighbouring protease di...
... action of EPA and DHA (Eur. J. Biochem. 271) 4465
Modulation of cyclin D1 synthesis and
hyperphosphorylation of Rb by n-3 and n-6 PUFAs
Induction of cyclin D1 is one of the e arliest effects of
mitogenic ... contribute to the modu-
lation of egr-1 gene expression (Fig. 4B).
Effects of n-3 and n-6 PUFAs on the synthesis
of caveolin-1 and caveolin-3 and on the loca...
... to learn thou-
sands of Chinese characters. The official agents in
Taiwan and China, respectively, chose 5401 and
3755 characters as important basic characters in
national standards. Consequently, ... e.g., “賣” and “讀” are pronounced as
/mai4/ and /du2/, respectively. In contrast, the pro-
nunciations of “匋”, “淘”, “陶”, and “啕
” are
/tao2/.
Pronunciations of specifi...
... consisting of the CSN, the 26S pro-
teasome and cullin-based Ub ligases. Permanent expression of a chimerical
subunit (Flag-CSN2-Rpn6) consisting of the N-terminal 343 amino acids
of CSN2 and of the ... role of the PCI domain of CSN2 for complex
formation and consequences of permanently overex-
pressed CSN2 for the stability of p53 and c-Jun.
The CSN interacts direct...
... Institute of Science and Technology, Ishikawa, Japan;
2
Department of Bioscience,
School of Science and Technology, Kwansei Gakuin University, Hyogo, Japan;
3
Department of Synthetic Chemistry
and ... T
m
of lysozyme was 77.3 °C in the absence
of additives. The addition of 100 m
M
polyamines and Arg
slightly increased the T
m
of lysozyme by 1 °Cand0.5°C,
respectively...
... Program of the Office of the Director of NIH and
by AIDS FIRCA Grant TW01001. The contents of this publication
do not necessarily reflect the views or policies of the Department of
Health and Human ... appropriate residues of enzyme and
Fig. 1. Sequence around the NC/p1 and p1/p6 cleavage sites in HIV-1.
The sequence of HIV-1
IIIB
, a member of the B subtype, is shown....
... Frequency of Request types
Since most of each dialogue consisted of the
making of requests, the first analysis examined
the frequency of the various kinds of requests in
the corpus of five ... by the National
Institute of Education under contract
US-NIE-C-400-76-0116 to the Center for the Study
of Reading of the University of Illinois and Bolt,
Beranek and New...