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Báo cáo Y học: Effect of the disease-causing mutations identified in human ribonuclease (RNase) H2 on the activities and stabilities of yeast RNase H2 and archaeal RNase HII pot

Báo cáo Y học: Effect of the disease-causing mutations identified in human ribonuclease (RNase) H2 on the activities and stabilities of yeast RNase H2 and archaeal RNase HII pot

Báo cáo Y học: Effect of the disease-causing mutations identified in human ribonuclease (RNase) H2 on the activities and stabilities of yeast RNase H2 and archaeal RNase HII pot

... as the wild-type protein suggests that reduction of RNase H2 activity may not be the only reason why mutations in the RNase H2 subunits cause AGS.Construction of mutant proteins of Tk -RNase HII Four ... present study, we used Sc -RNase H2 as amodel protein to analyze the effect of a disease-causing mutation on the activity and complex stability of human RNase H2. Information on the properties of this ... spectra.Conclusion In the present study, we used Sc -RNase H2* and Tk -RNase HII as model proteins to analyze the effect of a disease-causing mutation on the activity, stability, and structure of human...
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Báo cáo y học:

Báo cáo y học: "Effect of antibodies on the expression of Plasmodium falciparum circumsporozoite protein gene"

... with human erythrocytes in order to measure the ability of merozoite to invade erythrocytes in the presence of 1- 0.1 – 0.01 and 0.001μg/ml anti-CSP monoclonal antibody (mAb). The number of ring ... parasite development in the sporogonic [3 - 5], exoerythrocytic [6] and erythrocytic [7] cycle. However, there is almost no information on the effect of antibodies on the expression of Plasmodium ... stage infected erythrocytes of 3 replicates was counted. Efficacy of invasion was calculated as the percentage of ring infected erythrocytes of treated cultures over the percentage of ring infected...
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Báo cáo Y học: Effect of coenzymes and thyroid hormones on the dual activities of Xenopus cytosolic thyroid-hormone-binding protein (xCTBP) with aldehyde dehydrogenase activity potx

Báo cáo Y học: Effect of coenzymes and thyroid hormones on the dual activities of Xenopus cytosolic thyroid-hormone-binding protein (xCTBP) with aldehyde dehydrogenase activity potx

... retinal, kinetics of the inhibition of xCTBP/xALDH1 by T3was examined by variation of NAD+concentration within the reaction mixture. The Kmvalue, 9 lM, was independent of the concentration of ... Effect of coenzymes and thyroid hormones on the dual activities of Xenopuscytosolic thyroid-hormone-binding protein (xCTBP)with aldehyde dehydrogenase activityKiyoshi Yamauchi and Jun–ichiro ... NAD+/NADH and retinal reside in the N-terminal region, termed the NAD-binding domain, and in the C-terminal region, termed the catalytic domain,respectively [41]. We found previously that the thyroid-hormone-binding...
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Báo cáo Y học: Effect of ibuprofen and warfarin on the allosteric properties of haem– human serum albumin A spectroscopic study potx

Báo cáo Y học: Effect of ibuprofen and warfarin on the allosteric properties of haem– human serum albumin A spectroscopic study potx

... perturbation of the electronic absorbanceproperties of the chromophore without affecting the coordination number or the spin state of the haem-iron, and the quenching of the 1H-NMR relaxivity. Values ... model. Rather, terminal regions of sequential domains contribute to the formation of inter-domain helices linking domain I to II, and II to III,respectively. On the other hand, each domain is ... hexa-coordinated,possibly being bonded to His105 and Tyr148 as suggestedby docking simulations [7]. Upon drug binding, neither achange in the haem-iron atom coordination number, nor in the spin state...
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Báo cáo y học:

Báo cáo y học: " Effect of Weight Reduction on Cardiovascular Risk Factors and CD34-positive Cells in Circulatio"

... inflammation, contributing to the mainte-nance of energy homeostasis and the pathogenesis of obesity-related metabolic and inflammatory compli-cations [4]. Endothelial damage and dysfunction is considered ... during treatment may provide an indicator of improvement of vascular health. In our study, we analyzed the effect of weight loss on the improvement of lipid profile in plasma and the increase ... chorionic gonadotropin (HCG) in the treatment of obesity by means of the Simeons therapy: a criteria-based meta-analysis. Br J Clin Pharmacol. 1995; 40: 237-243. 27. Sutherland DR, Anderson...
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Báo cáo y học: "Effect of Acute Administration of an Herbal Preparation on Blood Pressure and Heart Rate in Humans"

... caffeine user group in response to the product containing caffeine and p-synephrine. The results of this study in- dicate that ingestion of a product containing bitter orange extract, caffeine and ... dietary supplement that contained 13 mg p-synephrine and 176 mg caffeine. On the following day, the subjects returned and repeated the protocol for data collection beginning 60 min after consuming ... change in heart rate. Gougeon et al. [19] reported that the thermic effect of food increased by 29% in 17 females after they ingested 26 mg p-synephrine. The thermic effect of p-synephrine was...
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Báo cáo y học:

Báo cáo y học: " Effect of dose-escalation of 5-fluorouracil on circadian variability of it"

... activity is inhib-ited by 5-FU administration [22], and this might con-tribute to the increase in the concentration of 5-FU in the second cycle compared to the first cycle in the standard ... shown in Figure 2. The disap-pearance of circadian rhythm in the 5-FU plasma concentration of the higher dose can be explained by the inhibition of DPD. In conclusion, the dose-escalation of ... car-cinoma (ESCC) which consists of a 120-hr-infusion of 5-FU at 400 mg/m2/day in weeks 1, 2, 6 and 7, infu-sion of CDDP at 40 mg/m2/day on the first day of week 1, 2, 6 and 7, and concurrent...
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Báo cáo y học:

Báo cáo y học: "Effect of 1,25-dihydroxy-vitamin D3 in experimental sepss"

... inflammatory cytokines, TNF-alpha and cer-tain interleukins play a key-role in initiating systemic inflammatory response syndrome (SIRS) and it is known that vitamin D may modulate the cytokine ex-pression ... shock re-sponse to induction of sepsis may therefore be reduced by administration of 1,25-vit D. In addition to these effects, Vitamin D may also inhibit the cytokines effect on target cells. ... D and, therefore, by both autocrine and paracrin stimulation influence their own macrophage activity in addition to the T- and B-lymphocyte dif-ferentiation and activity [11,12,13]. The inflammatory...
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Báo cáo y học:

Báo cáo y học: "Effect of corticosteroids on phlebitis induced by intravenous infusion of antineoplastic agents in rabbits"

... infiltration (Grades 1-3) in the proximal part of the vein in all 8 animals and in the distal part of the vein in 7 of the 8 animals. Edema (Grades 1-3) was found in the proximal part of the ... the vein in 6 of the 8 animals and in the distal part of the vein in 7 of the 8 animals. Epidermal degeneration (Grades 1-3) was found in both the proximal and distal parts of the vein in all ... by intravenous infusion of antineoplastic agents is one of the critical problems when anticancer therapy is prolonged. We have already reported that both rapid infusion and dilution of the injection...
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Báo cáo Y học: Effect of adenosine 5¢-[b,c-imido]triphosphate on myosin head domain movements Saturation transfer EPR measurements without low-power phase setting ppt

Báo cáo Y học: Effect of adenosine 5¢-[b,c-imido]triphosphate on myosin head domain movements Saturation transfer EPR measurements without low-power phase setting ppt

... states, indica-ting changes in the internal dynamics and domain orienta-tion of myosin. In the AdoPP[CH2]P state, approximatelyhalf of the myosin heads reflected the motional state of ADP–myosin, ... orientation in the myosin head than the widely used maleimide spinlabel [26]. Selective modification of Cys707 strongly affectsMgATP hydrolysis, and the motor function of myosinheads in the in vitro ... alterations in the internal structure of the myosin head region and the properties of binding to actin.Accordingly, our experiments support the view that the rotational motion of myosin reflects...
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