... perturbation of the electronic absorbanceproperties of the chromophore without affecting the coordination number or the spin state of the haem-iron, and the quenching of the 1H-NMR relaxivity. Values ... model. Rather, terminal regions of sequential domains contribute to the formation of inter-domain helices linking domain I to II, and II to III,respectively. On the other hand, each domain is ... hexa-coordinated,possibly being bonded to His105 and Tyr148 as suggestedby docking simulations [7]. Upon drug binding, neither achange in the haem-iron atom coordination number, nor in the spin state...