Báo cáo Y học: Effect of the disease-causing mutations identified in human ribonuclease (RNase) H2 on the activities and stabilities of yeast RNase H2 and archaeal RNase HII pot

... as the wild-type protein suggests that reduction of RNase H2 activity may not be the only reason why mutations in the RNase H2 subunits cause AGS. Construction of mutant proteins of Tk -RNase HII Four ... present study, we used Sc -RNase H2 as a model protein to analyze the effect of a disease-causing mutation on the activity and complex stability...

Ngày tải lên: 17/03/2014, 17:20

... with human erythrocytes in order to measure the ability of merozoite to invade erythrocytes in the presence of 1- 0.1 – 0.01 and 0.001μg/ml anti-CSP monoclonal antibody (mAb). The number of ring ... parasite development in the sporogonic [3 - 5], exoerythrocytic [6] and erythrocytic [7] cycle. However, there is almost no information on the effect of anti...

Ngày tải lên: 02/11/2012, 10:14

... retinal, kinetics of the inhibition of xCTBP/xALDH1 by T 3 was examined by variation of NAD + concentration within the reaction mixture. The K m value, 9 l M , was independent of the concentration of ... Effect of coenzymes and thyroid hormones on the dual activities of Xenopus cytosolic thyroid-hormone-binding protein (xCTBP) with aldehyde dehydrogenase activi...

Ngày tải lên: 31/03/2014, 21:21

... perturbation of the electronic absorbance properties of the chromophore without affecting the coordination number or the spin state of the haem-iron, and the quenching of the 1 H-NMR relaxivity. Values ... model. Rather, terminal regions of sequential domains contribute to the formation of inter- domain helices linking domain I to II, and II to III, respectivel...

Ngày tải lên: 31/03/2014, 23:20

... inflammation, contributing to the mainte- nance of energy homeostasis and the pathogenesis of obesity-related metabolic and inflammatory compli- cations [4]. Endothelial damage and dysfunction is considered ... during treatment may provide an indicator of improvement of vascular health. In our study, we analyzed the effect of weight loss on the improvement o...

Ngày tải lên: 25/10/2012, 10:51

... caffeine user group in response to the product containing caffeine and p-synephrine. The results of this study in- dicate that ingestion of a product containing bitter orange extract, caffeine and ... dietary supplement that contained 13 mg p-synephrine and 176 mg caffeine. On the following day, the subjects returned and repeated the protocol for data collection...

Ngày tải lên: 25/10/2012, 11:10

... activity is inhib- ited by 5-FU administration [22], and this might con- tribute to the increase in the concentration of 5-FU in the second cycle compared to the first cycle in the standard ... shown in Figure 2. The disap- pearance of circadian rhythm in the 5-FU plasma concentration of the higher dose can be explained by the inhibition of DPD. In co...

Ngày tải lên: 26/10/2012, 09:39

... inflammatory cytokines, TNF-alpha and cer- tain interleukins play a key-role in initiating systemic inflammatory response syndrome (SIRS) and it is known that vitamin D may modulate the cytokine ex- pression ... shock re- sponse to induction of sepsis may therefore be reduced by administration of 1,25-vit D . In addition to these effects, Vitamin D may also inhibit the cy...

Ngày tải lên: 26/10/2012, 09:57

... infiltration (Grades 1-3) in the proximal part of the vein in all 8 animals and in the distal part of the vein in 7 of the 8 animals. Edema (Grades 1-3) was found in the proximal part of the ... the vein in 6 of the 8 animals and in the distal part of the vein in 7 of the 8 animals. Epidermal degeneration (Grades 1-3) was found i...

Ngày tải lên: 26/10/2012, 09:57

... states, indica- ting changes in the internal dynamics and domain orienta- tion of myosin. In the AdoPP[CH 2 ]P state, approximately half of the myosin heads reflected the motional state of ADP–myosin, ... orientation in the myosin head than the widely used maleimide spin label [26]. Selective modification of Cys707 strongly affects MgATP hydrolysis, and the motor...

Ngày tải lên: 24/03/2014, 03:21