Báo cáo Y học: Introducing Wilson disease mutations into the zinc-transporting P-type ATPase ofEscherichia coli The mutation P634L in theÔhingeÕ motif (GDGXNDXP) perturbs the formation of the E2P state pdf
Báo cáo Y học: Introducing Wilson disease mutations into the zinc-transporting P-type ATPase ofEscherichia coli The mutation P634L in theÔhingeÕ motif (GDGXNDXP) perturbs the formation of the E2P state pdf
... Introducing Wilson disease mutations into the zinc-transporting P-type ATPase of Escherichia coli The mutation P634L in the ÔhingeÕ motif (GDGXNDXP) perturbs the formation of the E2P state Juha ... ATP during the catalytic cycle, hence the term P-type ATPases. Sequencemotifs typical of the heavy metal transporting P-type ATPases (P1-ATPases or CPx-ATPases) are presented in Fig. 1. The recently ... be linked to changes in Mg2+ligation so that in the E1 state Mg2+is ligated by residues in the hinge motif in the Pdomain and by residues in the N domain, whereas in the E2 state the latter...
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Báo cáo y học: " Introducing the Critical Care Forum’s ongoing review of medical statistics"
... is increasingly used in all fields of medicine but is often poorly understood and incorrectlyapplied. Critical Care is therefore launching a series of articles aimed at providing a simple introductionor ... those involved in research or the management of patients have a sound grasp of at least the basics of statistical methods. Unfortunately, in practice this isoften not true, with many relying on ... Available online http://ccforum.com/content/6/1/003 The science of statistics is increasingly employed in all fields of medicine. Statistical techniques are used not only byacademics and clinicians...
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Tài liệu Báo cáo Y học: BIGH3 (TGFBI) Arg124 mutations influence the amyloid conversion of related peptides in vitro Implications in the BIGH3-linked corneal dystrophies pptx
... peptides. In the same way, removing the CONH2-terminus of the peptides resulted in increasedamyloid fibril formation. This increase may be due to adirect inhibitory effect of this nine-amino-acid ... the peptides lacking the residues 110–113 (excluding the twovaline amino acids), showed a decrease in the formation of amyloid fibrils, suggesting the importance of the hydropho-bic NH2-end of the peptides. ... these disabling diseases.Keywords: amyloidosis; keratoepithelin; lattice corneal dys-trophy; granular corneal dystrophy; synthetic peptide.Hereditary corneal dystrophies are a cause of blindness.These...
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Báo cáo Y học: Mitochondrial DNA deletion mutations A causal role in sarcopenia docx
... missense mutations, protein synthesis mutations, copy number mutations and insertion-deletion mutations [1]. Mitochondrial deletion mutations present as human disease states in a number of mitochondrial ... consequence of both the decline in energy production and the increase in oxidativedamage in the region, the fiber is no longer capable of self-maintenance, resulting in the observed intrafiber atrophyand ... subsequently result in anincrease in the production of the nuclear subunits of the ETS system (i.e. the COX–/SDH++phenotype) (Fig. 3C).However, as the deletion mutations would continue toTable...
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Báo cáo y học: " Derivation and preliminary validation of an administrative claims-based algorithm for the effectiveness of medications for rheumatoid arthritis"
... scores independent of RA disease activity. As part of a sensitivity analysis, we restricted the cohort to patients without any of these ICD-9 codes as part of a sensitivity analysis. As part of ... (methotrexate; sulfasalazine; leflunomide; hydroxychloroquine) that they had not been already receiving in the 6 months prior to the index date Increase in biologic dose or frequency prohibited • ... pharmacy data. While clinical disease activity measures remain the gold standard for assessing effectiveness in RA, the many large administrative data sources in the U.S. and internationally are...
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Báo cáo y học: "Effect of Acute Administration of an Herbal Preparation on Blood Pressure and Heart Rate in Humans"
... and p-synephrine [8-11]. The safety of p-synephrine is clouded by its structural similarity to nor-epinephrine in spite of the fact that the pharma-cokinetics of the two compounds and the receptor ... properties of p-synephrine (hydroxyl group on the para position of the benzene ring) which is found in C. aurantium, and m-synephrine (phe-nylephrine; with the hydroxyl group on the meta po-sition) ... change in heart rate. Gougeon et al. [19] reported that the thermic effect of food increased by 29% in 17 females after they ingested 26 mg p-synephrine. The thermic effect of p-synephrine was...
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Báo cáo y học: "Thioglycosides as inhibitors of hSGLT1 and hSGLT2: Potential therapeutic agents for the control of hyperglycemia in diabetes"
... suggesting that differences in the aglycon binding site play an important role in the in- hibitory effect of this substance. In contrast, differ-ences in the sugar binding site resulted in an ... intestine and can be adminis-tered orally [27]. Therefore, the aim of the present study was to evaluate the inhibitory effect of some thioglycosides synthesized in our laboratory on human hSGLT1 ... key enzymes involved in the diges-tion of carbohydrates. Inhibition of glucose transport in the kidney through O-glycosides represents a different mecha-nism of action from other hypoglycemic...
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Báo cáo y học: "TPO, but not soluble-IL-6 receptor, levels increase after anagrelide treatment of thrombocythemia in chronic myeloproliferative disorders"
... Anagrelide is often used in the treatment of thrombocythemia in myeloproliferative disease (MPD), but infor-mation concerning effects of treatment on cytokines involved in regulation of blood platelet ... by in- hibition of megakaryocyte colony development, thereby reducing megakaryocyte size and ploidy, and disrupting or preventing full megakaryocyte matura-tion. However, little is known of ... always present in essential thrombocythemia (ET) and often in polycythemia vera (PV), myelofibrosis (MF) and chronic myelogenous leukemia. The risks associ-ated with thrombocythemia are thromboembolic...
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Báo cáo y học: "Comparison of a Two-Lead, Computerized, Resting ECG Signal Analysis Device, the MultiFunction-CardioGramsm or MCG (a.k.a. 3DMP), to Quantitative Coronary Angiography for the Detection of Relevant Coronary Artery Stenosis (70%)
... coronary stenosis according to whether the patients had prior revascularization. The boundaries of the box are Tukey’s hinges. The median is identified by the line inside the box. The length of the ... measured by the MCG device. The resulting mathematically integrated patterns of the abnormal indexes are then compared for their degree of abnormality to the abnormal index patterns in the reference ... mathematical systems analysis of the resting ECG in the frequency and time domains done using the MCG device ap-pears to provide a high sensitivity and specificity for the identification of...
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Tài liệu Báo cáo Y học: Ligand interactions and protein conformational changes of phosphopyridoxyl-labeled Escherichia coli phosphoenol pyruvate carboxykinase determined by fluorescence spectroscopy pdf
... properties. In this work we took advantage of the specific labelingwith PLP of Lys288 in E. coli PEP carboxykinase to gaininsight into conformational alterations of the protein uponligand binding in ... structure of E. coli PEP carb-oxykinase (1OEN) is covalently linked to the carbonyl carbon of the P-pyridoxyl group (PL) through an imino linkage. The green lineshows the protein backbone, the P-pyridoxyl ... that obtained in the presence of Mn2+(Table 1).An independent estimation of the binding affinity of PEPfor E. coli PEP carboxykinase was obtained from the quenching of the emission of Trp residues...
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