Báo cáo Y học: Introducing Wilson disease mutations into the zinc-transporting P-type ATPase ofEscherichia coli The mutation P634L in theÔhingeÕ motif (GDGXNDXP) perturbs the formation of the E2P state pdf
Báo cáo Y học: Introducing Wilson disease mutations into the zinc-transporting P-type ATPase ofEscherichia coli The mutation P634L in theÔhingeÕ motif (GDGXNDXP) perturbs the formation of the E2P state pdf
... Introducing Wilson disease mutations into the zinc-transporting P-type ATPase of Escherichia coli The mutation P634L in the ÔhingeÕ motif (GDGXNDXP) perturbs the formation of the E 2 P state Juha ... ATP during the catalytic cycle, hence the term P-type ATPases. Sequence motifs typical of the heavy metal transporting P-type ATPases...
Ngày tải lên: 17/03/2014, 17:20
Báo cáo y học: " Introducing the Critical Care Forum’s ongoing review of medical statistics"
... is increasingly used in all fields of medicine but is often poorly understood and incorrectly applied. Critical Care is therefore launching a series of articles aimed at providing a simple introduction or ... those involved in research or the management of patients have a sound grasp of at least the basics of statistical methods. Unfortunately, in practice this is often no...
Ngày tải lên: 25/10/2012, 10:45
Tài liệu Báo cáo Y học: BIGH3 (TGFBI) Arg124 mutations influence the amyloid conversion of related peptides in vitro Implications in the BIGH3-linked corneal dystrophies pptx
... peptides. In the same way, removing the CONH 2 -terminus of the peptides resulted in increased amyloid fibril formation. This increase may be due to a direct inhibitory effect of this nine-amino-acid ... the peptides lacking the residues 110–113 (excluding the two valine amino acids), showed a decrease in the formation of amyloid fibrils, suggesting the importance...
Ngày tải lên: 21/02/2014, 01:21
Báo cáo Y học: Mitochondrial DNA deletion mutations A causal role in sarcopenia docx
... missense mutations, protein synthesis mutations, copy number mutations and insertion-deletion mutations [1]. Mitochondrial deletion mutations present as human disease states in a number of mitochondrial ... consequence of both the decline in energy production and the increase in oxidative damage in the region, the fiber is no longer capable of self- maintenance...
Ngày tải lên: 17/03/2014, 23:20
Báo cáo y học: " Derivation and preliminary validation of an administrative claims-based algorithm for the effectiveness of medications for rheumatoid arthritis"
... scores independent of RA disease activity. As part of a sensitivity analysis, we restricted the cohort to patients without any of these ICD-9 codes as part of a sensitivity analysis. As part of ... (methotrexate; sulfasalazine; leflunomide; hydroxychloroquine) that they had not been already receiving in the 6 months prior to the index date Increase in biologic dose...
Ngày tải lên: 25/10/2012, 10:45
Báo cáo y học: "Effect of Acute Administration of an Herbal Preparation on Blood Pressure and Heart Rate in Humans"
... and p-synephrine [8-11]. The safety of p-synephrine is clouded by its structural similarity to nor-epinephrine in spite of the fact that the pharma- cokinetics of the two compounds and the receptor ... properties of p-synephrine (hydroxyl group on the para position of the benzene ring) which is found in C. aurantium, and m-synephrine (phe- nylephrine; with the...
Ngày tải lên: 25/10/2012, 11:10
Báo cáo y học: "Thioglycosides as inhibitors of hSGLT1 and hSGLT2: Potential therapeutic agents for the control of hyperglycemia in diabetes"
... suggesting that differences in the aglycon binding site play an important role in the in- hibitory effect of this substance. In contrast, differ- ences in the sugar binding site resulted in an ... intestine and can be adminis- tered orally [27]. Therefore, the aim of the present study was to evaluate the inhibitory effect of some thioglycosides synthesized i...
Ngày tải lên: 26/10/2012, 10:04
Báo cáo y học: "TPO, but not soluble-IL-6 receptor, levels increase after anagrelide treatment of thrombocythemia in chronic myeloproliferative disorders"
... Anagrelide is often used in the treatment of thrombocythemia in myeloproliferative disease (MPD), but infor- mation concerning effects of treatment on cytokines involved in regulation of blood platelet ... by in- hibition of megakaryocyte colony development, thereby reducing megakaryocyte size and ploidy, and disrupting or preventing full megakaryocyte matura- tion. How...
Ngày tải lên: 03/11/2012, 10:52
Báo cáo y học: "Comparison of a Two-Lead, Computerized, Resting ECG Signal Analysis Device, the MultiFunction-CardioGramsm or MCG (a.k.a. 3DMP), to Quantitative Coronary Angiography for the Detection of Relevant Coronary Artery Stenosis (70%)
... coronary stenosis according to whether the patients had prior revascularization. The boundaries of the box are Tukey’s hinges. The median is identified by the line inside the box. The length of the ... measured by the MCG device. The resulting mathematically integrated patterns of the abnormal indexes are then compared for their degree of abnormality to the...
Ngày tải lên: 03/11/2012, 10:58
Tài liệu Báo cáo Y học: Ligand interactions and protein conformational changes of phosphopyridoxyl-labeled Escherichia coli phosphoenol pyruvate carboxykinase determined by fluorescence spectroscopy pdf
... properties. In this work we took advantage of the specific labeling with PLP of Lys288 in E. coli PEP carboxykinase to gain insight into conformational alterations of the protein upon ligand binding in ... structure of E. coli PEP carb- oxykinase (1OEN) is covalently linked to the carbonyl carbon of the P-pyridoxyl group (PL) through an imino linkage. The green...
Ngày tải lên: 21/02/2014, 01:21