Báo cáo khoa học: Early signaling events induced by 280-nm UV irradiation pot

... particular, P38 was selectively activated by UV light at around 280 n m. In the present s tudy, we investigated early signaling events induced by UV irradiation at 280 nm using D T40 and PTK- defective ... increased UV (ultraviolet) light below 300 nm, and has signi®cant eects on biological systems. To better understand the eects of UV in this range, early signaling...

Ngày tải lên: 17/03/2014, 11:20

... QA accuracy by maximizing the log-likelihood of a set of question-and-answer pairs. Experimental results show that we achieve better QA ac- curacy using the resulting clusters than by using manually ... correlated with the log-likelihood of the q-a pairs computed by this statistical model. In Section 4 we propose an algorithm to cluster q-a pairs by maximizing the log-likelihood of a...

Ngày tải lên: 17/03/2014, 00:20

... algorithm. Initially thought for being used mostly by students from linguistics (or linguists) - due to the mathe- matical algorithms -, the tool can be exploited by anybody who wants to have an introductory ... Linguistics (CL). Having a flexible and extendible architec- ture, the system presents the students, by means of text, of visual elements (such as pictures and animations) and of...

Ngày tải lên: 17/03/2014, 02:20

... or a para- graph) is not strongly penalized by judges, whereas retuning a result from a category further up or down the scale (an article) is. One potential drawback of this study format is that ... productively combined to address this challenge. Acknowledgments. This work was supported in part by Powerset, Inc., and in part by Microsoft Re- search through the MSR European PhD Scholars...

Ngày tải lên: 23/03/2014, 17:20

... synthesis and febrile response induced by SEC1 is dependent on NADPH oxidase and not on PI3K ⁄ Akt or 5-LOX ⁄ FLAP because these phenomena are attenuated by apocynin and not by ETYA, MK 886, Wort or ... Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling. Oncogene 21, 1...

Ngày tải lên: 19/02/2014, 00:20

... (Fig. 1). These events have all been associated with the increased endothelial permeability (as measured by tracer molecules or trans- endothelial resistance) that is induced by VCAM-1 cross-linking. ... ROS signaling, endo- thelial integrity is also subject to regulation by the Rap1 GTPase, microtubule dynamics and by proteins that control VE-cadherin internalization. To what ex...

Ngày tải lên: 07/03/2014, 12:20

... a-helix content of S1, effects that are also counteracted by betaine. We conclude that urea -induced inactivation of the enzyme is caused by partial unfolding of the myosin catalytic domain. Abbreviations bis-ANS, ... that betaine pre- vents S1 from the unfolding and aggregation induced by urea. In order to better understand the kinetics of urea- induced S1 aggregation, we performe...

Ngày tải lên: 16/03/2014, 06:20

... recep- tors. Signaling by receptor protein kinases is thought to be mediated by agonist -induced ‘association’ mecha- nisms, whereas signaling by receptor GCs may be med- iated by agonist -induced ‘rotation’ ... activation and NPRA signaling Signaling by G-protein-coupled receptors may involve stimulation of AC by G s a, which is released from the heterotrimeric G-protein...

Ngày tải lên: 28/03/2014, 23:20

... Insulin secretion is stimulated by AMPA, KA and NMDA in MIN6 cells derived from insulin-secreting pancreatic b cells [58], and also induced by both AMPA and KA, but not by NMDA, in isolated pancreatic ... resorption by osteoclasts. Science 289, 1504–1508. 78. Patton, A.J., Genever, P.G., Birch, M.A., Suva, L.J. & Skerry, T.M. (1998) Expression of an N-methyl- D -aspartate-type r...

Ngày tải lên: 30/03/2014, 13:20

... stem cells are steered by several key players such as BMI-1, p21 and proteins of the FOXO family that are counter-regulated by the phosphatidylinositol 3 kinase (PI3K) ⁄ AKT signaling pathway [40]. ... between the above-described modes and which signaling pathways are involved? However, despite the high FLT3 expres- sion, which might be targeted by the potent inhibitors PKC412 of CE...

Ngày tải lên: 16/02/2014, 14:20