... arginase and agmatinase. This aspect is presently under investigation in our laboratory. In any case, despite the structural differences between agmatinase and arginase, agmatine and arginine ... the structural alignment. The alignment was then corrected by hand. Since the sequences of the two arginases and agmatinase greately differ in the N terminal region, the...
Ngày tải lên: 21/02/2014, 01:21
... Relief-Web (a media and NGO repository maintained by the Office for the Coordination of Human- itarian Affairs), the Uppsala Conflict Database Program (a database that contains information on armed ... survey to determine the validity of the study and the applicability of the findings to their settings. Public health scenario You are a physician working for an inte...
Ngày tải lên: 25/10/2012, 10:31
Báo cáo Y học: Novel fish hypothalamic neuropeptide Cloning of a cDNA encoding the precursor polypeptide and identification and localization of the mature peptide pptx
... carried out in a reaction mixture containing Taq polymerase [Ex Taq polymerase (Takara Shuzo, Kyoto, Japan) or gene Taq polymerase (NIPPON GENE, Tokyo, Japan)] and 0.2 m M dNTP on a thermal cycler ... lengths of poly (A) tail. The open reading frame region began with a start codon at position 16 and terminated with a TAA stop codon at position 607. A single polyadenyla...
Ngày tải lên: 08/03/2014, 16:20
Báo cáo Y học: Expression pattern in the antennae of a newly isolated lepidopteran Gq protein a subunit cDNA potx
... cDNA revealed that there is a polyadenylation signal upstream of the poly (A) . Analysis of the primary structure of M. brassicae Gqa The putative protein product encoded by the cloned cDNA was aligned ... liberating inositol 1,4,5-triphosphate (InsP 3 ) and diacylglycerol. Although cAMP and InsP 3 cascades appear to be active as two alternative pathways in vertebrate ol...
Ngày tải lên: 17/03/2014, 23:20
Báo cáo Y học: The mitochondrial-lysosomal axis theory of aging Accumulation of damaged mitochondria as a result of imperfect autophagocytosis ppt
... composition are basically the same in aging and disease. In a lysosome, where different organelles and a variety of proteins and other macromolecules are degraded, the milieu is acidic and reducing, partly ... explanation for many of the features of aging. A number of early explanations of aging, such as Orgel’s error catastrophe theory and the somatic mu...
Ngày tải lên: 17/03/2014, 23:20
Báo cáo Y học: Modeling the three-dimensional structure of H+-ATPase of Neurospora crassa Proposal for a proton pathway from the analysis of internal cavities pptx
... transports ions outs ide the cell in a n electrogenic way using energy from M gATP hydrolysis and its catalytic cycle is characterized by the formation of a covalent enzyme-aspartyl phosphate intermediate [2,3,42,43]. The ... model identify a string of internal polar cavities, tracing a well- defined pathway connecting the phosphorylation site in the extracellular...
Ngày tải lên: 23/03/2014, 21:20
Báo cáo y học: "Special considerations in the treatment of patients with bipolar disorder and medical co-morbidities"
... antiplatelet agents, warfarin or niacin. Carbamazepine acts as an inducer of cytochrome 3A4 , which may increase the metabolism of some anticoagulant and cardiovascular medications. Olanzapine may induce or ... with advanced cancer and pain. J Pain Symptom Manage 2002, 23:526-532. 83. Khojainova N, Santiago-Palma J, Kornick C, Breitbart W, Gonzales GR: Olanzapine in the manage...
Ngày tải lên: 25/10/2012, 10:51
Báo cáo khoa học: Broad antibiotic resistance profile of the subclass B3 metallo-b-lactamase GOB-1, a di-zinc enzyme potx
... substrate. In these cases, the k cat values were obtained from initial hydrolysis rates measured at saturating substrate concentrations. All data were analysed using Microsoft Excel and the kaleidagraph ... inactivation of wild-type and mutant GOB-1 by the chelating agent EDTA was followed using imipenem as a reporter substrate and measuring the initial rates of hydro- l...
Ngày tải lên: 14/03/2014, 23:20
Báo cáo khoa học: In vitro gamma-secretase cleavage of the Alzheimer’s amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc potx
... CTF migrating faster than C101-3FLAG as an a- CTF within 27 Da of the calculated molecular mass. Finally the same line was used to predict the molecular mass of a third FLAG-reactive protein between alpha ... R, Maruyama H, Koo EH, Haass C, Takio K, Morishima-Kawashima M, Ishiura S & Ihara Y (2003) Potential link between amyloid beta-protein 42 and C-terminal fragment gam...
Ngày tải lên: 16/03/2014, 23:20
Báo cáo y học: "Randomized trial comparing daily interruption of sedation and nursing-implemented sedation algorithm in medical intensive care unit patients"
... participated in study design, data analysis and interpretation, and drafting of the manuscript. WIJ partici- pated in data acquisition and drafting of the manuscript. SKE participated in study ... and were not involved in the DSMB's data analysis. The study was not terminated because of the finding of increased hospital mortality in patients treated by...
Ngày tải lên: 25/10/2012, 10:35