Báo cáo khoa học: Studies on the regulatory properties of the pterin cofactor and dopamine bound at the active site of human phenylalanine hydroxylase pptx

... 2003 Studies on the regulatory properties of the pterin cofactor and dopamine bound at the active site of human phenylalanine hydroxylase Therese Solstad 1 , Anne J. Stokka 1 , Ole A. Andersen 2 and ... fractional decrease of phos- phorylation rate seen at the concentration x of H 4 biopterin. v o is the rate in the absence of H 4 biopte...

Ngày tải lên: 17/03/2014, 09:20

... as the mold for the PCR- Quik reaction. Incorporating the oligonucleotide primers, each complementary to the opposite strand of the vector and containing the desired mutations, generated a mutated plasmid. ... D 2 R1, D 2 R2, D 2 R3). These experiments were performed to determine the influence of the introduced mutations on the localization of the receptor protein...

Ngày tải lên: 07/03/2014, 03:20

... (data not shown) allowed application of this assay. Under all conditions used, the reaction rate is directly proportional to the EcIPDC concentration and independent of the concentration of the ... addition of the cofactors. The enzyme is destabilized at low ionic strength. The stability of EcIPDC in aqueous solutions is higher than that of other PDCs. The rate...

Ngày tải lên: 08/03/2014, 02:20

... and the coordination of metal cofactors [19]. The functional importance of the conserved cysteine residues in iron–sulfur cluster coor- dination and protein disulfide reductase has been dem- onstrated ... that the iron–sulfur cluster of WhiB4 disintegrates under an oxidizing environment, but not under reducing conditions [15]. The rate of dis- integration was directly cor...

Ngày tải lên: 18/02/2014, 12:20

... polymerization and con- formational diseases such as the human serpinopathies. This review reports on recent major discoveries in the serpin field, based upon presentations made at the 4th International ... inhibitory activity and MENT positioning on chromatin. One of the major questions in the field of serpin bio- logy is the precise role and mechanism of functi...

Ngày tải lên: 30/03/2014, 20:20

... of the isomerization rate) of the methyl group of IPP and the (Z)-methyl group of DMAPP, and an even slower exchange (0.5% of the isomerization rate) of the olefinic hydrogen of DMAPP corresponding ... representation for the positioning of the substrate in the active site of IPP isomerase; (a) and (b) represent alternative paths for proton abstractio...

Ngày tải lên: 22/02/2014, 07:20

... and in the same relationship is searched for in the discourse information. Next, if there is no identi- cal pattern, a modification pattern with a synonym (Collins, 1984) of the node on one ... the discourse information. Then, if this also fails, a modification pattern containing a word that has the same part of speech as the word on one side of the node is sear...

Ngày tải lên: 08/03/2014, 07:20

... our name to the Association for Computational Linguistics in 1968, but that did not affect the continuity of the organization. The date of this panel, 17 June, misses the real anniversary by ... American Society for Information Science twice, and the Cognitive Science Society once. The convocation of the first International Conference on Computational Linguist...

Ngày tải lên: 08/03/2014, 18:20

... .more to the scope of the panel on social context than to the scope of this panel on the problem context. 4. Relation of expectations and functions: ~.i In the information seeking interaction, ... inforr~ation is essential in deter- minJ_ng expectations on the par~ of the user and the needs of the user. Within each type of interaction there can be...

Ngày tải lên: 17/03/2014, 19:20

... through the use of context-free grammar and then provided for the difficulties of the syntax by adding on to this base the use of transformations and of course, gaining turing machine power in the ... That is to say, they usa some form of informationally- reduced representation of the input speech wave- form and then contrive to match this representa- ti...

Ngày tải lên: 17/03/2014, 19:21