Báo cáo khoa học: Co-incorporation of Ab40 and Ab42 to form mixed pre-fibrillar aggregates ppt

... intensity indicating that labeled Ab40 incorporates into both aggregates of unlabeled Ab40 and Ab42. Similarly, labeled Ab42 was found to incorporate into both aggregates of unlabeled Ab40 and Ab42 (Fig. 3C). Significantly, ... 270) 663 Co-incorporation of Ab40 and Ab42 to form mixed pre-fibrillar aggregates David Frost 1 , Paul M. Gorman 1 , Christo...

Ngày tải lên: 17/03/2014, 09:20

... oligomers of vesicles made of acidic phospholipids resembles pore formation by A-b [27] and liposome permeabilization of a-synuclein [43]. The toxic activity exerted by prefi- brillar forms of stefin B and ... observed were specific to stefin B, rel- ative to its homolog, stefin A, which is not trans- formed into prefibrillar oligomers ⁄ aggregates under any of the conditions st...

Ngày tải lên: 07/03/2014, 17:20

... importance and a similar list of unhandled phenomena. Only occasionally were even informal evaluations of systems conducted. Recently, this has begun to change. In the last several years, many of ... answered and the database domaln+s semantics. All natural language access systems achieve some degree of success. But to make progress as a field, we need to be able t...

Ngày tải lên: 08/03/2014, 18:20

... linked to the development of IR and T2DM, and the latter contrib- utes profoundly to endothelium dysfunction and ED [130,131], the concept of androgen deficiency reinforces the important role of androgens ... to the onset of hypertension, dyslipide- mia, diabetes, thrombosis and atherosclerosis. In addition, increased conversion of cortisone to cortisol and increase...

Ngày tải lên: 18/02/2014, 06:20

... acetylation and ubiquitina- tion of Lys, and phosphorylation of Ser and Thr [16– 18]. Combinations of these modifications are suggested to constitute a ‘histone code’ that regulates the binding of protein ... highly basic histone proteins [14]. Two copies of each of the four core histones, H2A, H2B, H3, and H4, are assembled with DNA to form nucleosomes, which are the...

Ngày tải lên: 18/02/2014, 16:20

... attention was given to the banding patterns and different glycoforms of PrP C . In this study, we have analyzed the glycoform patterns of PrP C of human, sheep, cattle and mice and compared them. ... nonglycosylated isoform (m) of PrP C were quantified and calcu- lated as percentages of the total signal. The glycoforms of the pro- tein bands were analyzed as arithmetic me...

Ngày tải lên: 19/02/2014, 02:20

... highlighted in green and the nitrogen atoms of R120 and K22 in blue. The open form of MurA is unliganded (A) and the closed conformation (B) contains fosfo- mycin (orange) and UDPNAG (purple) ... Comparison of MALDI-TOF spectra between the masses of 1600 and 1800 for wild-type Enterobacter cloacae MurA (left) and the K22V mutant protein (right). (A and B) Tryptic diges...

Ngày tải lên: 19/02/2014, 13:20

... similar to that of English to permit word-for-word trans- lation from Russian to English. Further study of Russian texts shows that word order in scientific Russian is sufficiently different to ... words of their endings to identify them by their stems, which are listed in the dictionary. The purpose of this paper is to verify to what extent these assumptions are...

Ngày tải lên: 19/02/2014, 19:20

... investigated the effect of divalent cations on the binding of ICAM-4 transfectants to the I domains of CD11a and CD11b and compared the results to the divalent cation requirements of ICAM-1 and ICAM-2 transfectants. ... have been mapped to domains 4 and 5 of the ICAM-1 molecule [44]. None of these anti-ICAM-1 mAbs showed inhibitory effects on adhesion of ICAM-2 or...

Ngày tải lên: 20/02/2014, 11:20

... mutants corresponding either to b-subunits of the TSHR, or to a receptor deleted of almost the entire extracellular domain To understand the role of receptor cleavage and shedding, we constructed ... convenient tool with which to trace and quantify the cell surface expression of the receptors. To quantify the cell surface expression of the b1 mutant receptor, comparati...

Ngày tải lên: 21/02/2014, 00:20