Báo cáo khoa học: Novel aspects of calmodulin target recognition and activation pptx

... 2003 REVIEW ARTICLE Novel aspects of calmodulin target recognition and activation Stefan W. Vetter 1 and Estelle Leclerc 2 1 Department of Molecular Biology and 2 Department of Immunology, The ... the growing collection of the structural motifs recognizable by CaM. Ca 2+ activated K + -channel A radically novel target binding mode and possibly a novel mode o...

Ngày tải lên: 17/03/2014, 09:20

... in the levels of HSF1 and MTA1 (a component of the NuRD complex containing HDAC1 and HDAC2) proteins and to binding of HSF1 to MTA1 [78]. The complex is recruited to the promoters of estrogen-responsive genes ... the nucleus and binds to and regulates basal expression via HSEs of target genes [26]. Deletion of the HSF gene is lethal to cells, even at physiological temp...

Ngày tải lên: 18/02/2014, 04:20

... surface potential of AFP (left) and PAF (right) structures representing the orientation of the side chain lysine resi- dues. Lys9, Lys35 and Lys38 of PAF and Lys9, Lys32 and Arg35 of AFP are the ... chains. The hydrophobic strand b4 is located between Cys43 and Asp46 and, as a central strand of sheet 2, partici- pates in an extensive hydrogen bonding network with both str...

Ngày tải lên: 29/03/2014, 23:20

... consisting of entities and their variations. 6 Conclusions and Future work We study the task of NEN for tweets, a new genre of texts that are short and prone to noise. Two chal- lenges of this task ... set consists of 12,245 randomly sampled tweets within five days. 526 by recognition errors. Another challenge of NEN is the dearth of information in a single tweet, due to...

Ngày tải lên: 07/03/2014, 18:20

... joints of the hands and feet. The inflammatory process is characterized by infiltration of inflammatory cells into the joints, leading to proliferation of synoviocytes and destruction of cartilage and ... against the development of RA [61]. The gene copy number variations of CCL3-like 1 (CCL3L1), a nonallelic isoform of CCL3 encoded by different genes and a potent ligand fo...

Ngày tải lên: 18/02/2014, 18:20

... 0.5–1% of the popu- lation and causes progressive joint destruction that leads to the restriction of activities of daily living and deterioration of quality of life. Although the patho- genesis of ... 0.5–1% of the population. RA causes progressive joint destruction that leads to the restriction of activities of daily living and deterioration of quality of life. Al...

Ngày tải lên: 18/02/2014, 18:20

... TNF-a, CD40 ligand and Fas ligand, etc. (Fig. 3). Ligand bind- ing of various receptors results in the activation of phospholipase C (PLC), the release of inositol 1,4,5-tri- phosphate (IP 3 ), and a ... dose-dependent man- ner in the presence of PPAR-c ligands and a PPAR-a ligand, fenofibrate. Neither PPAR-a nor PPAR-c ligands inhibit basal level expression of these cyto- ki...

Ngày tải lên: 18/02/2014, 18:20

... inter- actions, and a nuclear localization signal [25,26]. The DNA-binding domain of ZF5 consists of the third and forth Zn-fingers [28]. Cyclic amplification and selection of targets (CAST) assays ... oligo(dT) primer and reverse transcriptase (Invitrogen) to make the first cDNA strand. Two pairs of primers, which amplify overlapping 5¢- and 3¢-parts of ZF5 cDNA, were design...

Ngày tải lên: 07/03/2014, 05:20

... unambiguously defined 12 and 13 resi- dues, respectively. Low glutamine signals at positions 12 and 15 of SrIA and at position 15 of SrIB Fig. 1. Purification of SrIA and SrIB. (A) Fractionation of the crude ... amino acid sequence determination and cloning of the cDNA encoding two novel peptides, SrIA and SrIB, found in the venom of Conus spurius. The pattern and th...

Ngày tải lên: 16/03/2014, 11:20

... peptides. Processing of the spectra was performed by the use of data analysis software package and biotools software from Bruker. A peptide mass tolerance of ± 2 Da, a fragment mass tolerance of ± 1 Da and one ... components of the 2-oxoglutarate and pyruvate dehydrogenase complexes were ascribed to the major protein bands of our preparation as follows: E1o (band 1), E2p (ba...

Ngày tải lên: 23/03/2014, 06:20