... 2003 Telomere length detection (Eur. J. Biochem. 270) 403
REVIEW ARTICLE
Assessment of telomere length and factors that contribute
to its stability
Sabita N. Saldanha
1
, Lucy G. Andrews
1
and ... evaluated.
Drugs that assist in telomere shortening may contribute to
tumor regression. Therefore, factors that contribute to
telomere stability may i...
... biosynthesis of androste-
nol, a potential endogenous ligand for the orphan receptors
constitutive androstane receptor and pregnane-X-receptor,
requires the presence of enzymes of the steroidogenic ... also in the
production of androstadienol which is considered to be an
intermediate in the 16-androstene pathway leading to the
biosynthesis of androstenol and of 5a(16)andro...
... time-consuming and
challenging [40–43].
To reduce the initial library to a size that is manage-
able by FACS and to demonstrate that full -length IgG
libraries can be displayed on phage particles and
undergo ... highest-affinity and lowest-affinity IgGs
were determined to have K
D
values of 1 and 440 nm,
respectively.
Enrichment of high-affinity and moderate-affinity...
... identified by its ability to bind to enhan-
cer regions of SV40 and human metallothionein IIA [1].
The AP-2 family of transcription factors is composed of
five members: AP-2a, AP-2b, AP-2c, AP-2d, and AP-2e
[2–7], ... day 16.5 and display a failure of chondrocyte
progenitor cells to differentiate into hypertrophic chon-
drocytes [56].
Two members of the Runx family of...
... mm
dithiothreitol for 30 min and then assayed. The level of
inactivation was determined by comparing the specific
activity of oxidized PhyAsr to that of enzyme that had not
been exposed to H
2
O
2
. ... average B -factors of the P-loop residues in the
unoxidized and oxidized structures were 14.3 A
˚
2
and
15.4 A
˚
2
, respectively. This is 4–5 A
˚
2
lower than the
overal...
... omparison of hydroden bonds (2.4–3.6 A
˚
) of inhibitors OE, RE and SE towards their HIV-1 proteases. Stated numbers are distances
between inhibitor and protease atoms in A
˚
.
Reside of Atoms of Inhibitor ... quality of refined m odel of t he native
HIV-1 protease c omplexed with inhibitor OE.
Parameter
No. of non-H protein atoms 1516
No. of non-H inhibitor atoms 50
No. o...
... 2004 Anti-mitogenic action of EPA and DHA (Eur. J. Biochem. 271) 4465
Modulation of cyclin D1 synthesis and
hyperphosphorylation of Rb by n-3 and n-6 PUFAs
Induction of cyclin D1 is one of the e ... effects of
mitogenic factors lea ding to cell c ycle re-entry, G1-phase
progression, and transition to t he DNA synthetic S phase.
We examined the effects of PUFA on cy...
...
Learning to read and write Chinese characters is a
challenging task for learners of Chinese. To read
everyday news articles, one needs to learn thou-
sands of Chinese characters. The official ...
as the manage-
ment of players’
accounts and the
maintenance of
players’ learning
profiles. Yet, due
to the page limits,
we focus on the
parts that are
most relevant...
... from cauliflower in the presence of ATP and
phosphatase inhibitors indicated that the CSN1 and
CSN6 subunits coelute in the same fractions as subunits
of the 26S regulatory complex. Moreover, coimmuno-
precipitations ... proteins such as p53 and regulate
the stability of the tumour suppressor towards the Ub
system [11]. It has been demonstrated that subunits of
the eIF3 com...
... presence of 100 m
M
spermidine and
spermine, the inactivation curve of 1.0 mgÆmL
)1
lysozyme
was identical to that of 0.2 mgÆmL
)1
lysozyme. The rate
constants of inactivation in the presence of spermidine ... Institute of Science and Technology, Ishikawa, Japan;
2
Department of Bioscience,
School of Science and Technology, Kwansei Gakuin University, Hyogo, Japan;
3...