Báo cáo khoa học: Assessment of telomere length and factors that contribute to its stability potx

... 2003 Telomere length detection (Eur. J. Biochem. 270) 403 REVIEW ARTICLE Assessment of telomere length and factors that contribute to its stability Sabita N. Saldanha 1 , Lucy G. Andrews 1 and ... evaluated. Drugs that assist in telomere shortening may contribute to tumor regression. Therefore, factors that contribute to telomere stability may i...

Ngày tải lên: 17/03/2014, 09:20

... biosynthesis of androste- nol, a potential endogenous ligand for the orphan receptors constitutive androstane receptor and pregnane-X-receptor, requires the presence of enzymes of the steroidogenic ... also in the production of androstadienol which is considered to be an intermediate in the 16-androstene pathway leading to the biosynthesis of androstenol and of 5a(16)andro...

Ngày tải lên: 08/03/2014, 08:20

... time-consuming and challenging [40–43]. To reduce the initial library to a size that is manage- able by FACS and to demonstrate that full -length IgG libraries can be displayed on phage particles and undergo ... highest-affinity and lowest-affinity IgGs were determined to have K D values of 1 and 440 nm, respectively. Enrichment of high-affinity and moderate-affinity...

Ngày tải lên: 22/03/2014, 21:21

... identified by its ability to bind to enhan- cer regions of SV40 and human metallothionein IIA [1]. The AP-2 family of transcription factors is composed of five members: AP-2a, AP-2b, AP-2c, AP-2d, and AP-2e [2–7], ... day 16.5 and display a failure of chondrocyte progenitor cells to differentiate into hypertrophic chon- drocytes [56]. Two members of the Runx family of...

Ngày tải lên: 16/02/2014, 09:20

... mm dithiothreitol for 30 min and then assayed. The level of inactivation was determined by comparing the specific activity of oxidized PhyAsr to that of enzyme that had not been exposed to H 2 O 2 . ... average B -factors of the P-loop residues in the unoxidized and oxidized structures were 14.3 A ˚ 2 and 15.4 A ˚ 2 , respectively. This is 4–5 A ˚ 2 lower than the overal...

Ngày tải lên: 18/02/2014, 18:20

... omparison of hydroden bonds (2.4–3.6 A ˚ ) of inhibitors OE, RE and SE towards their HIV-1 proteases. Stated numbers are distances between inhibitor and protease atoms in A ˚ . Reside of Atoms of Inhibitor ... quality of refined m odel of t he native HIV-1 protease c omplexed with inhibitor OE. Parameter No. of non-H protein atoms 1516 No. of non-H inhibitor atoms 50 No. o...

Ngày tải lên: 19/02/2014, 16:20

... 2004 Anti-mitogenic action of EPA and DHA (Eur. J. Biochem. 271) 4465 Modulation of cyclin D1 synthesis and hyperphosphorylation of Rb by n-3 and n-6 PUFAs Induction of cyclin D1 is one of the e ... effects of mitogenic factors lea ding to cell c ycle re-entry, G1-phase progression, and transition to t he DNA synthetic S phase. We examined the effects of PUFA on cy...

Ngày tải lên: 19/02/2014, 16:20

... Learning to read and write Chinese characters is a challenging task for learners of Chinese. To read everyday news articles, one needs to learn thou- sands of Chinese characters. The official ... as the manage- ment of players’ accounts and the maintenance of players’ learning profiles. Yet, due to the page limits, we focus on the parts that are most relevant...

Ngày tải lên: 19/02/2014, 19:20

... from cauliflower in the presence of ATP and phosphatase inhibitors indicated that the CSN1 and CSN6 subunits coelute in the same fractions as subunits of the 26S regulatory complex. Moreover, coimmuno- precipitations ... proteins such as p53 and regulate the stability of the tumour suppressor towards the Ub system [11]. It has been demonstrated that subunits of the eIF3 com...

Ngày tải lên: 20/02/2014, 01:20

... presence of 100 m M spermidine and spermine, the inactivation curve of 1.0 mgÆmL )1 lysozyme was identical to that of 0.2 mgÆmL )1 lysozyme. The rate constants of inactivation in the presence of spermidine ... Institute of Science and Technology, Ishikawa, Japan; 2 Department of Bioscience, School of Science and Technology, Kwansei Gakuin University, Hyogo, Japan; 3...

Ngày tải lên: 20/02/2014, 02:21