Báo cáo khoa học: Mixed lineage kinase LZK and antioxidant protein-1 activate NF-jB synergistically docx

... Mixed lineage kinase LZK and antioxidant protein-1 activate NF-jB synergistically Megumi Masaki, Atsushi Ikeda, Eriko Shiraki, Shogo Oka and Toshisuke Kawasaki Department ... kawasaki@pharm.kyoto-u.ac.jp Abbreviations: LZK, leucine zipper-bearing kinase; AOP-1, antioxidant protein-1; MLK, mixed lineage kinase; JNK, c-Jun NH 2 terminal kinase; MAPK, mitogen-act...

Ngày tải lên: 17/03/2014, 09:20

... regulation and mixed lineage leukemia. Acknowledgements We thank Imran Hussain, Sahba Kasiri, Bishakha Shrestha, Saoni Mandal and other Mandal lab mem- bers for useful discussion and critical ... 2010 FEBS MINIREVIEW Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing Khairul I. Ansari and Subhrangsu S. Mandal Department of Chemistry and...

Ngày tải lên: 16/02/2014, 14:20

... colorec- tal cancer, liver, breast and cervical cancers; and the demethylase, LSD1, is overexpressed in prostate can- cer. The implication of HMTs and demethylases in cancer and human diseases has led ... Recent Clin Trials 1, 169– 182. 162 Ansari KI & Mandal SS (2010) Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing. FEBS J doi:10.1111...

Ngày tải lên: 16/02/2014, 14:20

... available data and mechanisms identified in leukemic stem and leukemic tumor cells and link this informa- tion with the known functions of mixed lineage leukemia and certain mixed lineage leukemia ... and AF10 – has shed light on the activation cycle of P-TEFb kinase. All assemble in a high-molecular mass complex that binds to DOT1L and P-TEFb kinase [33]. AF4-bound P-TE...

Ngày tải lên: 16/02/2014, 14:20

... (2008) Structure of WDR5 bound to Mixed Lineage Leukemia Protein-1 peptide. J Biol Chem 283, 32158–32161. 25 Song JJ & Kingston RE (2008) WDR5 interacts with mixed lineage leukemia (MLL) protein ... 2010) doi:10.1111/j.1742-4658.2010.07609.x Several acute lymphoblastic and myelogenous leukemias are correlated with alterations in the human mixed lineage leukemia protein-1...

Ngày tải lên: 16/02/2014, 14:20

... first-strand buffer (Promega), 100 lm each of dATP, dGTP, dCTP, and dTTP (Invitrogen, Carlsbad, CA, USA), 1 mm dithiothreitol, and 20 units of RNaseOut (Invitrogen). The cDNA was diluted to 100 lL, and ... follicle as an estrogen target and source. Endocr Rev 27, 677–706. 11 Ansari KI, Mishra BP & Mandal SS (2008) Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and...

Ngày tải lên: 18/02/2014, 14:20

... spermidine, and spermine were 8.0–8.5, whereas those of the primary amines were 10.0–11.1 [34]. In biophysical aspects, polyamines can bind with nucleic acids and phospholipids, and stabilize and regulate ... Science, Sports and Culture of Japan (14350433, 14045229), a grant from the Science and Technology Incubation Program in Advanced Region by JST (Japan Science and Technolog...

Ngày tải lên: 20/02/2014, 02:21

... the one hand oz. On the other hand 13." and "Not only T- But also &" To- gether, they cannot be realised as "On the one hand o¢. Not only T. On the other hand 13. But ... demands a precise semantics for connect- ives, as in the work of Grote (1998), Grote et al. (1997), Jayez and Rossari (1998) and Lagerwerf (1998). Secondly, the approach demands an unders...

Ngày tải lên: 20/02/2014, 18:20

... the mixed- type mechan- ism as the most plausible alternative among the four candidate mechanistic models. The same conclusions were reached for neomycin B and neamine. Both compounds are mixed- type ... constant; K i , competitive inhibition constant; K is , inhibition constant; MAPKKide, mitogen-activated kinase kinase; [S], substrate concentration. 3054 FEBS Journal 273 (2006) 3054–3...

Ngày tải lên: 19/02/2014, 06:20

... receptor protein tyrosine kinase/ growth factor receptor binding protein 2-son of sevenless protein/Ras/Raf/mitogen activated protein kinase kinase/mitogen activated protein kinase pathway [13]. Another ... protein bands. The relative expression of PKB was calculated by the intensity ratio of PKB band and b-actin band. Assay of PKB activity PKB assay was performed with a widely used as...

Ngày tải lên: 21/02/2014, 00:20