Báo cáo khoa học: "TRANSFERS OF MEANING" doc

... show that we often find a single type of domain correspondence underlying two or more distinct semantic processes of transfer. Third, there are the language-specific instantiations of these oper- ... in virtue of its relation to another, explain an ab- stract domain by reference to a concrete one, and so forth. Second, there is the repertory of general linguistic processes o...

Ngày tải lên: 17/03/2014, 08:20

... Meaning of Discourse Markers Ben Hutchinson School of Informatics University of Edinburgh B.Hutchinson@sms.ed.ac.uk Abstract This paper applies machine learning techniques to acquiring aspects of ... in meaning of particular discourse markers (e.g. Best- gen et al. (2003)), this paper aims at a broad scale classification of a subclass of discourse markers: structural connectives....

Ngày tải lên: 08/03/2014, 04:22

... only after partial unfold- ing of the a-helix from the body of the b-sheet (Fig. 2C). Possible role of domain-swapping in the ‘off-pathway folding’ (OFF) model The OFF model for amyloid formation ... our understanding of the importance of different parts of the molecule and their flexibility in the process of amy- loid fibril formation often results more from a struc- tural analys...

Ngày tải lên: 14/02/2014, 18:20

... the induction of DNA fragmentation, which is one of the most typical characteristics of apoptosis. Regulators of DNA fragmentation One of the terminal processes of apoptosis is DNA degradation. During ... translocation of Bax and Bad to mitochon- dria independently of caspase activation [77,87]. Phosphorylation of caspases Phosphorylation of caspases switches the cellular...

Ngày tải lên: 14/02/2014, 22:20

... ARTICLE Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development Ann-Kathrin Wenke and Anja K. Bosserhoff Institute of Pathology, University of Regensburg, ... treatment of the chick face with RA, and this is accompanied by an increase in apoptosis [73]. The authors of this study ascribe the regulation of outgrowth of limb buds and patterning...

Ngày tải lên: 16/02/2014, 09:20

... the prodomain of ADAM10 acts not only as a transient inhibitor, but also as an internal chaperone in the mat- uration of the enzyme. Accordingly, the viral delivery of furin into the brain of AD model ... for ADAM10 that enhances a-sec- retase shedding of APP, probably by regulating matu- ration of the prodomain of ADAM10 [22]. The catalytical domain of ADAM10 contains a typic...

Ngày tải lên: 16/02/2014, 09:20

... analysis of structural changes and of the stability of proteins. We used tryptophan fluorescence in order to deter- mine whether the exposure of immunoglobulin Fig. 4. Low-pH buffer exposure of IgG ... spectra of 32 l M ANS in the absence or presence of 2 lM native, pH 4 buffer-exposed or pH 2.8 buffer-exposed IVIg. (D) Comparison of the fluorescence characteristics of increas...

Ngày tải lên: 16/02/2014, 15:20

... of ETA, or whether it involves the dual het- erogeneous part of the toxin. Use of this approach will provide novel insight(s) into the physiological signifi- cance of the endosomal fragments of ... to the mechanism of translocation of internal- ized ETA into the cytosol. The first translocation path- way has been proposed to operate at an early stage of endocytosis from endocyti...

Ngày tải lên: 18/02/2014, 04:20

... deletion of which renders HSF1 constitu- tively trimeric [19,20]. All HSFs bind DNA sequences that are called heat shock elements (HSEs) and are composed of an array of inverted repeats of the ... of the HSEs [23,25]. The precise composition of an HSE can also determine the state of activation required of a specific HSF to induce transcription of its target genes [21,24]. Thi...

Ngày tải lên: 18/02/2014, 04:20

... O 2 reduction [1]. The overall outcome of the catalytic cycle is reduction of one mole- cule of dioxygen into two molecules of water, coupled with oxidation of four substrate molecules (phenols ... a variant of a M. thermophila laccase capable of resisting a wide array of co-solvents at con- centrations as high as 50% v ⁄ v [14]. In all available examples of molecular evolut...

Ngày tải lên: 18/02/2014, 06:20