... proteinkinases including myosin light chain kinase (MLCK),CaM kinases I, II and IV (CaMKI, CaMKII andCaMKIV, respectively), CaM kinase kinase (CaMKK),titin kinase, and death associated kinase ... extension to the protein kinase folds backon the kinase domain and interferes with the substratebinding sites. In the case of the titin and twitchinkinases, the autoinhibitory sequence acts ... hexadecameric enzyme consisting of four copies of four subunits: (abcd)4. An intrinsic calmodulin (CaM, the dsubunit) binds directly to the c protein kinase chain. The interaction site of CaM on c has...