Báo cáo khoa học: "Should we Translate the Documents or the Queries in Cross-language Information Retrieval?" ppt

... more weakly, with K i ¼ 33 nm, comparable to the inhibition of the aminopeptidase cathepsin H (K i ¼ 30 nm ). In comparison with other cystatins, cystatin F is a rather slow binding inhibitor of ... cystatin F we have studied the in vitro kinetics of the interaction between cystatin F and several cathepsins, as well as their intracellular localization in promonocyte U937 cells...

Ngày tải lên: 19/02/2014, 17:20

... avoided (Table 1). There is therefore a much weaker driving force for folding the connecting linkers when compared with a globular protein. In addition, the main polar uncharged side chains (Asn, Gln, ... near the N- and C-termini of the linkers: this suggests that a mobile connection with both the catalytic domain and the binding module is required for the function of the n...

Ngày tải lên: 14/02/2014, 18:20

... assembly. In the first model, both hydrophobic translocators exist in oligomeric form, with the major partner inserted stably into the membrane, whereas the minor protein is the link with the V antigen. ... PopB in P. aeruginosa, IpaB in Shigella spp. and EspD in pathogenic E. coli spp.), whereas the smallest protein (i.e. the minor translocator; YopD, PopD, IpaC and...

Ngày tải lên: 14/02/2014, 22:20

... chain corresponding to the catalytic domain (C domain); and the B chain corresponding to the translocation domain (T domain) and the receptor-binding domain. The C and T domains remain covalently linked ... to insertion of the toxin in the membrane. The C domain is then translocated across the endosomal membrane into the cytosol. The C domain ADP-ribosylates the elon...

Ngày tải lên: 16/02/2014, 09:20

... attacking the microbe membrane, and in the intracellular com- partment, they contribute to the oxygen-independent killing of phagocytosed microorganisms. Furthermore, defensins are mediators in the ... a chemokine involved in homeo- static lymphocyte homing as well as in epithelial cell migration, further suggesting a function for hBD2 in healing and protection of the inte...

Ngày tải lên: 18/02/2014, 06:20

... [27– 29]. In the light of these effects, the complex regulatory and structural properties of hTK1 may be important for maintaining a balanced supply of the DNA precur- sor. This underlines the importance ... in the following G 1 phase implies predominance of the low-activity dimer form. As the hTK1 concentration increases during S phase, more and more enzyme will be in th...

Ngày tải lên: 18/02/2014, 12:20

... any interaction with the PDZ domains investigated. We furthermore investigated the binding determi- nants in the C-terminus of hOR2AG1 by spotting pep- tides that correspond to mutated or shortened ... 5C). In summary, when the interaction between MUPP1 and OR2 AG1 is inhibited by over-expressing the interacting PDZ domains, the resulting response of OR2 AG1 to odorant i...

Ngày tải lên: 18/02/2014, 13:20

... Starting with each complex in the training set containing one or more RRM or KH domains, we extracted the protein coordinates and the four nucleotides bound at the center of the domain (for structures ... contact- counting score; the blue line represents the rank of these sequences using the distance-dependent potential. The points in each colored line are sorted i...

Ngày tải lên: 18/02/2014, 16:20

... and Gln59 in the C-terminal end of helix III, are located apart from the major cluster, towards the lower intercept of the theoretical curve and fitting line (Fig. 4, left inset), where the motion ... only within helix III, but also over a large portion of the protein, from Phe8 to Met56, including the loop and the tight turn. At the same time, in the vicinity of the...

Ngày tải lên: 18/02/2014, 16:20

... trifluoroacetic acid in H 2 O. The retention times of adenosine and adenine, inosine and hyp- oxantine, guanosine and guanine, uridine and uracil, cyti- dine and cytosine were 12.2 and 6.2 min, ... carried out by incu- bating recombinant SsCU-NH with proteinase K, subtili- sin, trypsin or thermolysin. Enzymatic digestion with proteinase K, subtilisin or trypsin was performed in 10 mm...

Ngày tải lên: 18/02/2014, 17:20