... Interestingly, in our model, dopamine induces an increase of the actinbundles regulator fascin 1 [27] and discordant changesof two calcium-dependent, actin-associated proteins(annexins A2 and ... understanding of the biochemical pathways involved in PD neurodegenera-tion. Indeed, the triggers leading to the specific deathof dopaminergic neurons of SNpc, as well as the proteins altered during ... histo-grams), in that a-synuclein overexpression modulated the dopamine effect [profilin 1, enolase 1, RuvB-like 1,collapsin response mediator protein 4 (CRMP4) and lamin A ⁄ C, mitofilin]. These proteins...