Báo cáo khoa học: Thyroid Ca2+/NADPH-dependent H2O2 generation is partially inhibited by propylthiouracil and methimazole ppt

... Thyroid Ca 2+ /NADPH-dependent H 2 O 2 generation is partially inhibited by propylthiouracil and methimazole Andrea C. Freitas Ferreira, Luciene de Carvalho Cardoso, Doris Rosenthal and Denise ... effects. Keywords: antithyroid drugs; H 2 O 2 ;NADPHoxidase; thyroid. The mechanism by which antithyroid drugs, such as propylthiouracil (PTU) and 1-methyl-2-mercaptoimida...

Ngày tải lên: 17/03/2014, 03:20

... with this hypothesis, we have shown recently that MUC2 and MUC4 are transcriptionally regulated by Cdx homeodomain proteins and GATA factors [14–16]. Thyroid transcription factor-1 (TTF-1) is an important ... 10) and cold T84 (lane 16); supershift analysis with anti-GATA-4 (lanes 5, 11 and 17), anti-GATA-5 (lanes 6, 12 and 18) and anti-GATA-6 (lane 7, 13 and 19) IgGs. The...

Ngày tải lên: 15/03/2014, 00:20

... challenges in this field is provided, and the insights that may be gained from a greater under- standing of the mechanism of dual targeting for the targeting of location-specific proteins is discussed. Targeting ... chloroplasts (Toc)64 and Toc159 system used by proteins involved in photosynthesis [36]. The Toc159 family in Arabidopsis consists of four proteins: Toc159, Toc132, Toc120...

Ngày tải lên: 07/03/2014, 03:20

... pro- liferation and suppress apoptosis of islet cells [53–55]. It is conceivable that this effect of leptin is mediated by activation of STAT5. An unexpected finding was the capability of Tyr1138, which is ... mammals and birds [15,16]. Tyr1138 is located in a canonical box3 motif (Tyr-x-x-Gln) and recruits the transcription factor STAT3, which is subsequently phosphorylated...

Ngày tải lên: 07/03/2014, 16:20

... generation of phosphatidylinositol (3,4,5)-trisphosphate from phos- phatidylinositol (4,5)-bisphosphate, a reaction that is reversed by the enzymes phosphatase and tensin homo- logue (PTEN) and ... metabolism, development, cell cycle progression, migration and sur- vival [1–4]. The Akt subfamily of protein kinases con- sists of three isoforms – Akt1, Akt2 and Akt3 (also termed P...

Ngày tải lên: 16/03/2014, 05:20

... q i .w and q i .t are the word and its POS tag in the queue. dist(s 0 ,s 1 ) is the linear distance between the head-words of s 0 and s 1 . subtrees s 0 , s 1 , . . . (s 0 is the top tree) and Q ... ENDORSE A CANDIDATE (9) AL GORE HAS PROMISED THAT HE WOULD ENDORSE A CANDIDATE FOR (10) AL GORE HIS PROMISE THAT HE WOULD ENDORSE A CANDIDATE Figure 1: Example of repeated substructure...

Ngày tải lên: 16/03/2014, 19:20

... replication is stimulated by NF-I in vivo but not in vitro support this explanation [50]. This view is consistent with the knowledge that introducing an SV40 sequence into the JCV genome Fig. 4. SV40 and ... a-primase is at least in part involved when compounded by other factors not present in our assays. This view is supported by the recent finding that the JC virus receptor...

Ngày tải lên: 17/03/2014, 03:20

... tactic, prosodic and pragmatic information as well as tense and aspect and sortal information. An ex- ample of a VIT for the sentence Montag ist gut ('Monday is fine') is given in (1). ... ponent in Verbmobil-2 is to collect these partial analyses and try to put them together on the basis of heuristic rules to produce deep linguistic analy- ses even if the inp...

Ngày tải lên: 17/03/2014, 07:20

... significance it has in the visual cycle is unclear. The investment in creat- ing the unique lipid composition of the OS discs, and the existence of other visual disorders caused by aber- rant lipid sorting ... [19,48], indicate that this is a critical process to enable vision. As ABCA4 is localized exclusively to this membrane, it is likely that its activ- ity is also influenced...

Ngày tải lên: 22/03/2014, 15:21

... material by biolistic transformation, and the location of GFP fluorescence was determined by confocal microscopy as described [19]. Results Generation of fusion constructs and mutagenesis of the ... phosphorylation motif described by Waegeman and Soll [13]. (B) The transit peptides of tobacco and pea SSU and Arabidopsis CtRS and HtRS, with the phosphorylation motif underlin...

Ngày tải lên: 23/03/2014, 12:20