Báo cáo khoa học: Tetranectin binds hepatocyte growth factor and tissue-type plasminogen activator potx

... Tetranectin binds hepatocyte growth factor and tissue-type plasminogen activator Uffe B. Westergaard, Mikkel H. Andersen, Christian W. Heegaard, Sergey N. Fedosov and Torben E. ... hepatocyte growth factor (HGF) and tissue-type plasminogen activator (tPA), whereas three related proteins: macrophage-stimulating protein (MSP), urokinase-type plasminogen acti...

Ngày tải lên: 17/03/2014, 03:20

... Colicelli J (2008) Integration of transforming growth factor beta and RAS signaling silences a RAB5 guanine nucleotide exchange factor and enhances growth factor- directed cell migration. Mol Cell Biol ... PRK2 and p38 MAPK and the transcriptional upregulation of smooth muscle-specific genes such as a-SMA, SM-MHC and SM-22a via the cooperation of serum response factor, GATA...

Ngày tải lên: 07/03/2014, 01:20

... intracellular RNA and the expression of proapoptotic and antiapoptotic mRNAs. For four cell lines, we visualized cellular RNA by fluorescence microscopy, and determined RNA levels, viability and apoptosis ... catalyzes RNA cleavage without the need for metal ions and cofactors. Cloning and sequencing of the binase gene have been reported [22], and a three- dimensional structure a...

Ngày tải lên: 06/03/2014, 09:22

... ranked list (Luhn 1958). Figures 2D, E and F show the standard deviation be- tween the document and sentence space, the document and term space and the sentence and term space respectively. These ... sentence, and term, spaces in our corpora of more than one-hundred thousand full-text docu- ments; Section 4 discusses the results; and Sec- tion 5 draws conclusions from this...

Ngày tải lên: 17/03/2014, 04:20

... gel in denaturing and reducing condi- tions, and by western blotting. (A) Coomassie-stained bands of isolated Hpt (lane 1), standard ApoE (lane 2), standard ApoA-I (lane 3), and partially purified ... HRP-conjugated avidin and ECL. Coomassie- stained bands of VLDL and LDL proteins are shown in lanes 1 and 2, respectively. VLDL and LDL proteins, blotted onto the PVDF membrane and...

Ngày tải lên: 07/03/2014, 00:20

... recep- tors [20,21] and requires both calcium and calmodulin to exert its activity on Ras [18,21]. The protein is phos- phorylated on serine, threonine and tyrosine residues in vivo and is a substrate ... 6). Supernatants and pellets were isolated by centrifugation, and equal volumes were used for SDS ⁄ PAGE and analyzed by immuno- blotting using monoclonal antibodies to a-tubul...

Ngày tải lên: 07/03/2014, 12:20

... loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK Alamdar Hussain 1,2, *, Liang Yu 1,3, *, Rani Faryal 1,2 , Dara K. Mohammad 1 , Abdalla J. Mohamed 1,4 and C. I. Edvard ... COS7 and 293T cells and did not vary like BTK–SYK; therefore, the differences in the PH–TH domains remain the decisive factor for this variation. The B-cell adapter protein...

Ngày tải lên: 14/02/2014, 18:20

... PAI-1, plasminogen activator inhibitor-1; PTM, post- translational modification; TAA, tumor-associated antigen; tPA, tissue-type plasminogen activator; uPA, urokinase-type plasminogen activator; uPAR, ... levels of plasminogen activation and malignancy [46,52]. Higher expression levels of uPA and ⁄ or plasminogen activator inhibitor-1 (PAI-1) in tumor tissues correlate w...

Ngày tải lên: 14/02/2014, 19:20

... apoptosis and maintaining mitochon- drial homeostasis and function. Silencing TRAP1 enhances cytochrome c release from the mitochondria and apoptosis induced by b-hydroxyisovalerylshikonin and VP16 ... understanding of the protective role of TRAP1 in cardiomyocytes and offer new consid- erations for myocardial protection after burn shock. Materials and methods Cardiomyocyte cultur...

Ngày tải lên: 16/02/2014, 14:20

... poly- disperse, and the chondroitin sulfates exist as co-poly- mers of the 4- and 6-sulfate isomers (Ch4S, Ch6S) with various compositions and mean molecular masses that depend on animal species and tissue. ... described by Schechter and Berger [26], the four amino acids of H-TNVV-OMe bind at posi- tions S 4 -S 3 -S 2 -S 1 in the same order as written, i.e. T binds to S 4 and so...

Ngày tải lên: 16/02/2014, 14:20