... loss-of-functionof BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYKAlamdar Hussain1,2,*, Liang Yu1,3,*, Rani Faryal1,2, Dara K. Mohammad1, Abdalla J. Mohamed1,4 and C. I. Edvard ... COS7 and 293Tcells and did not vary like BTK–SYK; therefore, thedifferences in the PH–TH domains remain the decisive factor for this variation.The B-cell adapter protein BLNK (SLP-65) and itsT-cell ... our under-standing of signaling mechanisms in general.Mutation spectrum in XLA and genotype–phenotype correlationsFigure 1 depicts the linear organization of the domainsin BTK and Fig. 2 shows...