Báo cáo khoa học: Nitric oxide-induced epidermal growth factor-dependent phosphorylations in A431 tumour cells pot

... Ca ´ diz, Spain Nitric oxide (NO • ) strongly inhibits the proliferation of human A431 tumour cells. It also inhibits tyrosine phos- phorylation of a 170-kDa band corresponding to the epidermal growth ... respectively, at tyrosine or tyrosine/threonine residues. The active (a) and inactive (i) forms of the different proteins are indicated. Nitrosative stress in A431 tumour ce...

Ngày tải lên: 17/03/2014, 03:20

... folding in vivo The folding in vivo of an extracellular protein containin g disulfide-rich domains, the low-density lipoprotein recep- tor, has s hed new light on the folding process in the livin ... doi:10.1111/j.1432-1033.2004.04363.x itself is in fact expresse d as a 150–180 kDa multidomain type I membrane protein [17] con taining nine EGF-like domains. The soluble 53 residue EGF co...

Ngày tải lên: 23/03/2014, 13:20

... domain containing (SHC), mitogen-activated protein kinase kinase (MEK) and extracellular signal-regulated protein kinase (ERK) in the absence or presence of EGF (Figs 6B and S1B). Interestingly, ... 5243 direct binding to the kinase domain [15,24–26]. ERR- FI1 expression was significantly induced in EGFR-WT and L858R cells. Although ERRFI1 was reduced in response to EGF stimulation in...

Ngày tải lên: 30/03/2014, 01:20

... plasminogen-tetranectin complex. The study also revealed that tetranectin did not interact with the kindred proteins: macrophage-stimulating protein, urokinase-type plasminogen activator and prothrombin. In order ... affinity towards the kringle-4 domain of plasminogen (Plg) [2]. Each of the three 20 kDa-monomers consists of an N-terminal heparin-bind- ing domain, an a-helical domain involve...

Ngày tải lên: 17/03/2014, 03:20

... analysis. Each of the remaining terms has, on average, 4.45 distinct anno- tations. The information from multiple annotators was combined by taking the majority vote, result- ing in a lexicon with 8,813 ... certain colour categories (for example, danger with red, and softness with pink), complementing linguistic and non-linguistic information with appro- priate colours has a number of benefi...

Ngày tải lên: 07/03/2014, 22:20

... two training hy- potheses listed in Table 2, yielding two models, B and J. Table 3 shows the increasing accuracy of both models in describing the text reuse in L train as more features are incorporated. ... global linear models in (Collins, 2002), we cast this task as learning a mapping F from input verses x ∈ X to a text-reuse hypothesis y ∈ Y ∪ {}. X is the set of verses in the t...

Ngày tải lên: 08/03/2014, 02:21

... requests (CRs) in conversa- tion ensure and maintain mutual under- standing and thus play a crucial role in robust dialogue interaction. In this pa- per, we describe a corpus study of CRs in task-oriented ... a differ- ent one: instead of explaining causes of CRs within a theoretic-semantic model (as the three different readings of Ginzburg and Cooper (2001) do), they infer the interp...

Ngày tải lên: 08/03/2014, 04:22

... result, obtained in an experimental model consisting of in vitro cells, is in agreement with results obtained using animals or everted intestinal tissue [21–24]. It is 0 246 150 300 Scattered Intensity (relative ... only maintain Ca 2+ in an absorbable form but also interact with the plasma membranes of certain cells, facilitating Ca 2+ uptake. Concerning the conflicting results of h...

Ngày tải lên: 16/03/2014, 05:20

... with the HupT ⁄ HoxJ kinase in vitro [4]. The role of the N-terminal part of the kinase, containing a PAS domain, was established in signal transduction between the RH and the kinase [6,7]. Addition ... [25]. In Rhodopseudomonas palustris CGA009, the photosys- tem is synthesized in the dark due to a single point mutation in the helix–turn–helix DNA binding motif of PpsR, rendering i...

Ngày tải lên: 16/03/2014, 23:20

... constraints were introduced in (Wu, 1995). The applications were, for instance, the segmenta- tion of Chinese character sequences into Chinese “words” and the bracketing of the source sentence into ... describe the IBM constraints. 2.1 ITG Constraints Let us now consider the ITG constraints. Here, we interpret the input sentence as a sequence of blocks. In the beginning, each position is...

Ngày tải lên: 17/03/2014, 06:20