Báo cáo khoa học: Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer’s disease brain doc

... control in Alzheimer’s disease X. Li et al. 4220 FEBS Journal 272 (2005) 4211–4220 ª 2005 FEBS Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer’s disease ... correla- tion with tau nonphosphorylated at Tau1 sites. Total and phosphorylated levels of eEF2K and eEF2 in AD...

Ngày tải lên: 16/03/2014, 22:20

... signal-regulated kinase; JKAP, c-JUN N-terminal kinase pathway-associated phosphatase; JNK, c-JUN N-terminal kinase; JSP, c-JUN N-terminal kinase stimulatory phosphatase; JSP1-CS, inactive mutant of JSP1 (active ... [37]. Myristoylation can also in uence the movement and final destination of a signaling protein within the cell. We observed that myristoylation of JSP1 deter- mine...

Ngày tải lên: 16/02/2014, 14:20

... pheromones to elicit a mating response in cells of the opposite mating type. Cdc42 is involved in pheromone signal- ling that eventually results in G 1 arrest and the for- mation of a mating projection ... formation of a mating projection [28]. Furthermore, homologues of oxysterol- binding proteins, a family of proteins that regulate the synthesis and transport of sterol...

Ngày tải lên: 18/02/2014, 13:20

... Analysis of two CBP (cAMP-response-element-binding protein-binding protein) interacting sites in GRIP1 (glucocorticoid receptor-interacting protein), and their importance for the function of GRIP1. ... conforma- tional change of GRIP1 might have resulted from inter- and intramolecular interactions within its C-ter- minal and other regions. Hence, the modulation of GRIP1 tran...

Ngày tải lên: 07/03/2014, 12:20

... Activation of p38 mitogen-activated protein kinase and c-Jun NH(2)-terminal kinase by double- stranded RNA and encephalomyocarditis virus: involve- ment of RNase L, protein kinase R, and alternative pathways. ... and stimulate innate and adaptive immune responses [1–3]. Among the kinases activated are mitogen-activated protein kinase, Jun-N-terminal kinase (JNK) and p...

Ngày tải lên: 07/03/2014, 21:20

... biochemical actions of sphingolipid-derived messengers such as S1P were mediated through various protein kinase and monomeric GTP-binding protein signaling pathways including MAP kinases and Rho GTPases ... were treated with specific inhibitors for either protein kinase C, PI 3 -kinase or p42/p44 MAP kinase. Similarly, a specific protein kinase A (PKA) Fig. 6. Selective inhibiti...

Ngày tải lên: 08/03/2014, 08:20

... clarification of its mechanism Xingguo Liang 1 , Ryuji Wakuda 1 , Kenta Fujioka 1 and Hiroyuki Asanuma 1,2 1 Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya ... transcription of the GFP gene initiated by the photoresponsive T7 pro- moter involving two Azos. Fig. S3. Direct observation of differences in binding affinity between the trans–t...

Ngày tải lên: 15/03/2014, 10:20

... depending on TPT1 promoter sequences or TCTP mRNA 5¢⁄3¢-UTRs and investiga- tion of the interaction of RNA-binding proteins with UTRs by UV-cross- linking. PMA, forskolin, dioxin, cobalt and nickel ... transcription with actinomy- cin D and followed the kinetics of TCTP mRNA decay (Fig. 6). Interestingly, inhibition of transcription by actinomycin D treatment did not acceler...

Ngày tải lên: 16/03/2014, 05:20

... FEBS interaction of berberine with quadruplex. The occur- rence of sharp isobestic points at 359, 383 and 445 nm clearly indicates the existence of equilibrium in the binding. Ligand binding with ... limits the interaction to a single binding mode. It was seen that addition of increasing concentrations of quadruplex results in a gradual increase in the fluorescence intens...

Ngày tải lên: 16/03/2014, 06:20

... view of red- lined box in overall structure. Green lines represent intimate molecular interactions including hydrogen bond networks in vicinity of Thr15 on intertwined N-terminal arm. H-bond information ... assay solution, and examined for their remaining activity using 1 mm l-tyrosine as the substrate. The remaining activity of the mutant and native enzymes decreased according...

Ngày tải lên: 16/03/2014, 12:20