Báo cáo khoa học: Biochemical network models simplified by balanced truncation ppt

... Liebermeister et al. Complexity reduction of biochemical networks FEBS Journal 272 (2005) 4034–4043 ª 2005 FEBS 4043 Biochemical network models simplified by balanced truncation Wolfram Liebermeister 1 , ... Moreover, by tuning the dimensionality, one can choose a compromise between approximation accuracy and numerical effi- ciency. Balanced truncation has successfully bee...

Ngày tải lên: 16/03/2014, 22:20

... Flow Network Models for Word Alignment and Terminology Extraction from Bilingual Corpora l~ric Gaussier ... sink, to control the flow quantity we want to go through the words. 2.1 Flow networks We meet here the notion of flow networks that we can formalise in the following way (we as- sume that the ... refer the interested reader to (Ford and Fulkerson, 1962; Klein, 1967). 2.2...

Ngày tải lên: 17/03/2014, 07:20

... grain. The purification by three chromatographic steps resulted in a final enrich- ment of SPC4 by 105-fold, with an activity yield of 28% (Table 1). The purity of SPC4 was assessed by the single protein ... determined by hydrolysis in 2 m trifluoroacetic acid at 100 °C for 2 h. After hydrolysis, the sample was dried, then dissolved in water, centrifuged (10 000 g, 10 min), and analyzed...

Ngày tải lên: 16/03/2014, 13:20

... set was also used by Thater et al. (2009, TDP09). The results in Table 4 compare these models against our best previous exemplar models and show that our models outperform these models across the ... observations, we computed a third model, actTP, that activates both T (by kNN) and P (by percentage), ranking paraphrases by sim(act(P, s), act(T, s)). Table 3 shows the re- sults....

Ngày tải lên: 30/03/2014, 21:20

... samples of DNA modified by the platinum complex at a prese- lected value of r b . The samples of DNA modified by new platinum compound and analyzed further by bio- physical or biochemical methods ... was incubated with 2 lg of pSP73KB DNA linearized by EcoRI. The plati- nated samples were precipitated by ethanol and analyzed DNA recognition by p53 protein K. Stehlı ´ kova ´ et al....

Ngày tải lên: 16/03/2014, 14:20

... correct tag (recall). This informa- tion can be used by forcing each tagger also to add to the vote for tags suggested by the oppo- sition, by an amount equal to 1 minus the recall on the opposing ... of the tokens tagged X by the tagger are also tagged X in the benchmark and recall measures which percentage of the tokens tagged X in the benchmark are also tagged X by the ta...

Ngày tải lên: 17/03/2014, 07:20

... and active biochemical subnetworks and examine the conse- quences of interactions between such subnetworks. By a passive subnetwork, we mean the collection of the reactions in the network that ... passive subnetwork are dynamic, and all the internal fluxes are balanced. In this case, by a simple analogy with a subnetwork of resistors, there should be no current loops in this subnetwor...

Ngày tải lên: 17/03/2014, 09:20

... (third and fifth panel) models are closer to the full model (first panel) than the fully simplified models. S. Bulik et al. Kinetic hybrid models composed of mechanistic and simplified rate laws FEBS ... goodness of these simplified models was evaluated by using the solutions of the full mechanistic model as the reference standard. In most cases that were tested, the simplified m...

Ngày tải lên: 23/03/2014, 06:20

... para- sites in vitro [12]. The compound 6(S)-fluoroshikimate, produced by AstraZeneca Inc. (London, UK), is con- verted to 6-fluorochorismate by the subsequent enzymes in the shikimate pathway, thus 6(S)-fluoros- hikimate ... was cloned, expressed, and purified in E. coli system, and its biochemical and enzymatic characterizations were also carried out. Furthermore, by using the high- thr...

Ngày tải lên: 19/02/2014, 05:20

... accordingly. Also in this reaction two compounds were produced by glut- aconate CoA-transferase. The molecules were separ- ated by HPLC, analyzed by mass spectrometry and were found to both have the same ... this common intermediate by enzymes present in the fibroblast homogenate (e.g. by 3-hydroxy-3-methylglutaryl-CoA lyase; EC 4.1.3.4). Therefore, 3-MG-CoA (10 lm) was replaced by...

Ngày tải lên: 19/02/2014, 07:20