Báo cáo khoa học: Methods to monitor the quaternary structure of G protein-coupled receptors doc

... 2925 MINIREVIEW Methods to monitor the quaternary structure of G protein-coupled receptors Graeme Milligan 1 and Michel Bouvier 2 1 Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, ... fused to the energy donor Rluc and increasing concentration of a GPCR fused to the energy acceptor GFP 2 . The BRET levels are plotted as a functio...

Ngày tải lên: 16/03/2014, 22:20

... Markov models (HHMM). The HHMM structure allows repeated parts of the model to be merged together. A merged model takes advantage of the recurring patterns within the hierarchy, and the clusters that ... )))). where only the part -of- speech tags and grammar information are considered. The left hand side of the figure shows the original structure of the sen- t...

Ngày tải lên: 08/03/2014, 02:21

... connected to each other. In par- ticular, note that the orienting relation between John's going to the hospital, e2, and the doctor's diagnosis, e4, is automatically incorporated into the ... compositionally; e .g. , [e6 before e5], i.e., the breaking of the ankle, e6, is before the state John is in at the time of the doctor's talking to him, e...

Ngày tải lên: 17/03/2014, 08:20

... CCC AGG TTG CTG GGG GAT GTC AGC ACG D3 forward CAT CCT GAC CTC CCC TAG CAA CCT GGG D3 reverse CCC AGG TTG CTA GGG GAG GTC AGG ATG Catalysis in a contiguous trimeric creatine kinase G. G. Hoffman ... AAT TGG ATG GCC D1 reverse CCT TTC TCG AGT CTC TTC TCC D2 forward GAG ACT CGA GAA AGG AGA GG D2 reverse GGC AGA CGT CAG CAG TGG D3 forward CCA CTG CTG ACG TCT GCC D3 reverse ATC AGC CTA GGC CCT...

Ngày tải lên: 16/03/2014, 06:20

... belonging to a given category. To summarize the advantage of the ls~ter method, (1) to (4) follows. (i) The only one natural conceptural categories structure should be given as the basis of ... realizability of the structure (e .g. from the standpoint of easiness of data collection and arrangement, easiness of realization and compact- ness of the siz...

Ngày tải lên: 31/03/2014, 17:20

... stress Bimei Jiang 1 , Bin Zhang 1 , Pengfei Liang 2 , Juan Song 1 , Hongbing Deng 1 , Zizhi Tu 1 , Gonghua Deng 1 and Xianzhong Xiao 1 1 Department of Pathophysiology, Xiangya School of Medicine, ... lost. Taken together, our results demonstrate an impor- tant relationship among the regulation of nucleo- lin ⁄ C23, the activation of caspase-3 and the induction of apoptosis un...

Ngày tải lên: 16/02/2014, 09:20

... ATnI 232)292 corresponds to RTnI 96)181 and should have two TnC-binding sites, the inhibitory region and the regulatory TnC-binding site. Therefore, this suggests that TnC-binding affinities of these regions of the ... TnC-binding sites, respect- ively, of TnI, and suggested that the C-terminal region of TnI (including the inhibitory region and the regula- tory TnC-bindin...

Ngày tải lên: 20/02/2014, 01:20

... Example segmentation hypotheses higher than Seg. #2 (e .g. , due to the high fre- quency of the observed morph “+m”). On the other hand, a bilingual segmenter is expected to assign a higher alignment ... scheme “EN” of Habash and Sadat (2006). In Lee (2004), the goal is to match the lexical granularities of the two languages by starting with a fine-grained seg- mentatio...

Ngày tải lên: 20/02/2014, 04:20

... measures. Rather, we propose to use features based on the transitive closure of the dependency relation of the event and that of the de- pendency relation of the sentence. Our aim was to achieve ... use the following, two-tiered strategy. Let d e , d s be elements of E  e and E  s , with d x .d de- noting the index of the word that is the descendant in d x...

Ngày tải lên: 20/02/2014, 09:20

... of the substrate bound to the subunit capable of catalyzing hydrolysis. Therefore, binding of Mg 2+ in a negatively cooperative fashion to the M3 site of dimeric APase increases the rate of the ... Zn 2+ binding to the magnesium binding site M3 [4]. Fig. 4. The influence of Mg 2+ on the kinetic properties of APase from E. coli. The influence of Mg 2+ on...

Ngày tải lên: 21/02/2014, 00:20