Báo cáo khoa học: "Computational Approaches to Sentence Completion" docx

... on the interaction of a-conotoxins with neuronal nicotinic receptors in light of our new understanding of the receptor structure. Computational tools are expected to reveal the molecular recognition mechanisms ... muscle subtype, thanks to the large amount of the receptor obtained from the electric organ of the Torpedo marmorata ray and availability of selective pharmacological tools like...

Ngày tải lên: 19/02/2014, 12:20

... common to organic synthesis but not yet amenable to protein modification. As new methodologies emerge, the study of other PTMs and that of regulatory PTMs will hope- fully provide a powerful tool ... ARTICLE Chemical approaches to mapping the function of post-translational modifications David P. Gamblin, Sander I. van Kasteren, Justin M. Chalker and Benjamin G. Davis Chemistry Research...

Ngày tải lên: 18/02/2014, 17:20

... long day), we want to be able both to understand what makes proteins ÔtickÕ andtoengineer proteins with native-like properties. In this review we discuss combinatorial approaches toward understanding ... than NNN toward Leu, Ser and Arg, and includes only one stop codon). However, the natural repertoire of amino acids is highly restrictive compared to the useful alterations that can b...

Ngày tải lên: 19/02/2014, 12:20

... SYNTACTIC APPROACHES TO AUTOMATIC BOOK INDEXING Gerard Salton Department of Computer Science Cornell University Ithaca, NY 14853 ABSTRACT Automatic book indexing systems ... available know-how in automatic indexing, satisfactory book indexing sys- tems may be developed. AUTOMATIC PHRASE CONSTRUCTION Book indexing systems differ from standard automatic text indexing ... document...

Ngày tải lên: 08/03/2014, 18:20

... HCT116 cells to proteasome inhibitors. Int J Oncol 24, 935–941. 19 Falchuk KH, Goetzl EJ & Kulka JP (1970) Respiratory gases of synovial fluids. An approach to synovial tissue circulatory–metabolic ... [2,3]. Tumour necrosis factor-related apoptosis-inducing ligands (TRAILs) are type II transmembrane mole- cules that trigger the apoptotic signal cascade by bind- ing to cognate recept...

Ngày tải lên: 18/02/2014, 14:20

... binding to this crystallin by ITC and determined the binding constant for the calcium mimic probe. Terbium is believed to bind strongly to calcium-binding sites of proteins compared to calcium due to ... was grown in terrific broth to mid log phase at 37 °C. When the A 600 was between 0.6 and 1.0, isopropyl thio-b-d-galactoside was added to the final concentration of 1 mm to ind...

Ngày tải lên: 18/02/2014, 16:20

... storage compartments for a number of pro-death proteins, such as cytochrome c, which are released into the cytoplasm as a consequence of apoptotic signals. The release of these apoptotic factors ... normally found soluble in the cytoplasm, its apoptotic activation includes extensive structural reor- ganization, which facilitates targeting to, and insertion into, the mitochondrial outer membr...

Ngày tải lên: 19/02/2014, 07:20

... receptor’s primary sequence shows stri- king similarities to the somatostatin receptor family, most notably in the transmembrane domains. The pharmacological relatedness of somatostatin receptors is ... receptor was initially considered to only couple Ga q proteins, the receptor seems to be involved in an array of interactions with other signa- ling molecules whose full spectrum remains...

Ngày tải lên: 19/02/2014, 07:20

... the hematopoietic cytokine receptor family, activates the MAP kinase signaling cascade to a much lesser extent than receptor tyrosine kinases, such as the epidermal growth factor receptor or the ... proteins to be ana- lyzed on the same immunoblot and to share the same antibody epitope. As the CCD camera-based detection is proportional to the number of epitopes, it can even be applied...

Ngày tải lên: 19/02/2014, 07:20

... chunk -to- string model into two models: a loose model (Section 2.1) which is more similar to the hierarchical phrase-based model and a tight model (Section 2.2) which is more similar to the tree -to- string model. The ... hierarchical chunk -to- string model into two models: a loose model which is more similar to the hierarchical phrase-based model and a tight model which is more simil...

Ngày tải lên: 19/02/2014, 19:20