Báo cáo khoa học: Nature, nurture and neurology: gene–environment interactions in neurodegenerative disease docx

... gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes. Cell 72, 971–983. 6 Young AB (2003) Huntingtin in health and disease. J Clin Invest 111, ... and A. J. Hannan Gene–environment interactions in neurodegenerative disease FEBS Journal 272 (2005) 2347–2361 ª 2005 FEBS 2361 REVIEW ARTICLE Nature, nurture and neuro...

Ngày tải lên: 16/03/2014, 19:20

... 2008 FEBS MINIREVIEW Membrane compartments and purinergic signalling: P2X receptors in neurodegenerative and neuroinflammatory events Savina Apolloni, Cinzia Montilli, Pamela Finocchi and Susanna ... microglia and astrocytes in the proximity of degenerating neurons is a patholog- ical hallmark generally seen in MND and in models of ALS, the line between neurodegenerative...

Ngày tải lên: 30/03/2014, 02:20

... inhibited the expression of VEGF, thereby suppressing the growth of hepatocarcinoma tumors in mice [87]. In addition, no noticeable increase in inflammatory cytokines, including interferon-a and ... worms, insects, plants and humans [1]. A single strand of exogenously introduced double-stranded small interfering RNA (siRNA; 20–30 nucleotides) guides an RNA-inducing silencing protein...

Ngày tải lên: 06/03/2014, 01:23

... by Levin and Prince (1982), namely that gapping is acceptable only with the purely conjunc- tive symmetric meaning of and conjoining the clauses, and not with its causal asymmetric meaning (para- ... licity for other coordinating conjunctions as discussed in Kehler (1994), as well as why gapping is infelicitous in constructions with subordinating conjunctions indi- cating Cohere...

Ngày tải lên: 08/03/2014, 07:20

... objects following the robot’s instructions, and learning and remem- bering to make a snowman and an L shape. We measured task success in two ways, correspond- ing to these two main tasks. The ... human-robot dialogue system. In Pro- ceedings of IJCAI 2009. M. Huber, M. Rickert, A. Knoll, T. Brandt, and S. Glasauer. 2008. Human-robot interaction in handing-over tasks. In Procee...

Ngày tải lên: 17/03/2014, 01:20

... important in the literature and have roles assigned [12–18,20]: *, CTP-binding residue of the P-loop; (*), CTP-binding residue; ^, Neu5Ac-binding residue; #, Neu5Ac-binding residue forming part ... 540 ± 10 s )1 and 130 ± 9 lm in its absence. In order to identify residues in the wild-type N. meningitidis CNS with potential roles in substrate discrimination or in forming the bi...

Ngày tải lên: 22/03/2014, 21:21

... for protein folding in eukaryotic cells. Defects in protein folding contribute to a growing list of diseases, and advances in our understanding of the molec- ular details of protein folding are helping ... genome, and understanding their specific func- tions and interrelationships is of considerable impor- tance, given their value to industry and medicine. Protein folding in vi...

Ngày tải lên: 29/03/2014, 22:21

... states, each comprising a condi- tion of the stack and the input string. The final state in the parse is an empty input string and a stack containing only the root symbol, SNT. In an unambiguous ... resulting in differing operations contradicto- ries that need to be studied and resolved. The resulting minimal grammar totaling 895 rules succeeds in parsing the texts with on...

Ngày tải lên: 31/03/2014, 06:20

... b-ketothiolase; PaaZ, unknown, putative ring-cleavage enzyme, aldehyde dehydrogenase domain (N-terminus), MaoC-like protein domain (C-terminus). PaaX and PaaY may be involved in regulation. 3048 W. Ismail ... phosphate, pH 4, containing 8% (v/v) acetonitrile for 15 min and then developed with a linear gradient of 8–40% acetonitrile in the same buffer for 5min.The flowratewas 1mLÆmin )1...

Ngày tải lên: 23/03/2014, 18:20

... training and test data for the models using additional features included NP- and non-NP-antecedents. For each data set we followed the iterative procedure outlined in Section 5.1. In the following ... http://www.r-project.org). We used the standard pruning and control settings for RPART (cp=0.0001, minsplit=20, minbucket=7). All results reported were obtained by performing 20-fold c...

Ngày tải lên: 23/03/2014, 19:20