Báo cáo khoa học: Dual role of oxygen during lipoxygenase reactions potx

... regulation of miR-27 expression. Our data suggest that the miR-27 gene family is potentially an important class of negative regulators of adipogene- sis and may play a role in the regulation of adipose functions ... differentiation In order to investigate the role of miRNAs in the regu- lation of adipogenic differentiation, we performed a genome-wide microarray analysis of m...

Ngày tải lên: 18/02/2014, 08:20

... data are suggestive of a role of mem- branes, in particular of negatively charged membranes, in the mechanism of action of RNases, we investigated the ability of a series of RNases to destabilize ... shows the shape of the electrostatic field of BS-RNase seen from different directions. Figure S3 compares the electrostatic field of different Fig. 5. Plot of the EIE values...

Ngày tải lên: 19/02/2014, 06:20

... Molecular Basis of Disease 3.1 Oxidative Stress S3.1-1 The role of antioxidants in the cytotoxicity of chemotherapeutic drugs T. Ozben, H. Akbas, I. Akan, S. Akan and M. Timur Department of Biochemistry, ... Processing S3.2-1 The role of the human mismatch repair system in the processing of modified nucleotides N. Mojas, F. Fischer, M. Lopes, P. Cejka and J. Jiricny Institute...

Ngày tải lên: 19/02/2014, 07:20

... formation of supercomplexes and the effect of the absence of intact complex I, but the results are too preliminary in this regard. Heterologous expression of the ESSS-HA subunit The localization of ... exhaustive biochemical analysis of the composition of complex I from bovine heart has revealed the existence of two additional subunits (bringing the total to 46), and one of...

Ngày tải lên: 19/02/2014, 16:20

... activity. 1-Deoxymannojirimycin inhibits the GABA-uptake of GAT1 In order to gain further insight into the role of the terminal structures of the N-glycans of GAT1, N-gly- cosylation processing of NNN was inhibited by 1-de- oxymannojirimycin ... membrane traffick- ing and reduced stability of the N-glycosylation mutants of GAT1 must be a result of misfolding of these protei...

Ngày tải lên: 19/02/2014, 17:20

... modeling of SEA domain of MUC1 The composer and biopolymer modules of the sybyl 6.91 software package (Tripos Inc., St Louis, MO, USA) were used for comparative molecular modelling of the human MUC1 ... further investigate the role of the SEA domain in cleavage of membrane-tethered mucins we carried out site-directed mutagenesis of the FRPG ⁄ SVVV site and evaluated hybrid muc...

Ngày tải lên: 19/02/2014, 18:20

... activity of MGD1 is of general value in the mechanism of action of defensins. However, our results could be compared with results obtained by other groups who also point to the role of the connecting ... structural feature of the mode of action, although the precise role of the loop was not elucidated. In conclusion, our results indicated that residues 23–35 of mussel de...

Ngày tải lên: 20/02/2014, 11:20

... increased. The effect of the size of the residue at position 169 may be related to the solvent accessibility of the side-chain of His210 (Fig. 3C). When the accessibility of the side-chain of His210 increased, ... surface areas (ASA) of individual residues in the API variants were calculated with the INSIGHT II/DISCOVER software. The radius of the solvent probe was 1.4 A ˚ . M...

Ngày tải lên: 21/02/2014, 03:20

... The Role Of Focussing in Interpretation of Pronouns Candace L. Sidner Artificial Intelligence Laboratory Massachusetts Institute of Technology Cambridge, MA ... the formal relationship between the process of focussing and interpret;ition of pronominal anaphora. The discussion of focussing extends the work of Grosz [1977]. Foct,ssing is defined algorithmical]y ... A...

Ngày tải lên: 21/02/2014, 20:20

... benefit of this annotation scheme is that in our corpus the majority of turns can be automatically labeled: questions often ended in question marks; commands often started with verbs; a list of ... about financial and software problems. In the TODs, as we would expect, the expert had initiative most of the time (91% of the turns). However, ADs have closer to an equal sharing of...

Ngày tải lên: 22/02/2014, 02:20