Báo cáo khoa học: Dual role of oxygen during lipoxygenase reactions potx
Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt
... regulation of miR-27 expression. Ourdata suggest that the miR-27 gene family is potentiallyan important class of negative regulators of adipogene-sis and may play a role in the regulation of adiposefunctions ... differentiationIn order to investigate the role of miRNAs in the regu-lation of adipogenic differentiation, we performed agenome-wide microarray analysis of miRNA expres-sion during adipogenic differentiation ... that downregulation of miR-27 is not sufficient to promote adipogenesis.We performed a time course study to gain furtherinsights into the role of miR-27 during different stages of adipogenesis (Fig....
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Tài liệu Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases docx
... data are suggestive of a role of mem-branes, in particular of negatively charged membranes,in the mechanism of action of RNases, we investigatedthe ability of a series of RNases to destabilize ... shows the shape of the electrostaticfield of BS-RNase seen from different directions.Figure S3 compares the electrostatic field of differentFig. 5. Plot of the EIE values as function of rotation ... carboxylates of residuesAsp38 and Glu111. In RNase-AA-GG the ‘basic sur-face’ is more similar to that of BS-RNase because of the removal of the four carboxylates. The ‘basic sur-face’ of the mutant...
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Tài liệu Báo cáo khoa học: The role of antioxidants in the cytotoxicity of chemotherapeutic drugs pptx
... Molecular Basis of Disease3.1 Oxidative StressS3.1-1The role of antioxidants in the cytotoxicity of chemotherapeutic drugsT. Ozben, H. Akbas, I. Akan, S. Akan and M. TimurDepartment of Biochemistry, ... ProcessingS3.2-1The role of the human mismatch repairsystem in the processing of modifiednucleotidesN. Mojas, F. Fischer, M. Lopes, P. Cejka and J. JiricnyInstitute of Molecular Cancer Research, University of ... steatohepatitis,activation of glucose uptake during hyperinsulinemic–euglycemicclamp, and amelioration of ASCVD in animal models of theMetabolic Syndrome.S3.5-2Why a metabolic syndrome?P. G. KopelmanInstitute of...
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Tài liệu Báo cáo khoa học: The role of the ESSS protein in the assembly of a functional and stable mammalian mitochondrial complex I (NADH-ubiquinone oxidoreductase) pptx
... formation of supercomplexes and the effect of the absence of intact complex I, but the results are toopreliminary in this regard.Heterologous expression of the ESSS-HA subunitThe localization of ... exhaustivebiochemical analysis of the composition of complex I frombovine heart has revealed the existence of two additionalsubunits (bringing the total to 46), and one of these, theESSS protein, ... .4), 0.1 mgÆmL)1 of NADH and 2.5 mgÆmL)1 of nitroblue tetrazolium (Sigma)for 2–4 h.Other reagentsAll other reagents were of the highest grade available.ResultsIdentification of ESSS as essential...
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Tài liệu Báo cáo khoa học: The role of N-glycosylation in the stability, trafficking and GABA-uptake of GABA-transporter 1 Terminal N-glycans facilitate efficient GABA-uptake activity of the GABA transporter pptx
... activity.1-Deoxymannojirimycin inhibits the GABA-uptake of GAT1In order to gain further insight into the role of theterminal structures of the N-glycans of GAT1, N-gly-cosylation processing of NNN was inhibited by 1-de-oxymannojirimycin ... membrane traffick-ing and reduced stability of the N-glycosylationmutants of GAT1 must be a result of misfolding of these proteins.The deficiency of N-glycosylation results in a mark-edly reduced ... normalized for the surface pro-tein of these mutants. Double N-glycosylation mutantsshowed a marked reduction of GABA-uptake activity of 60–40% of that of the wild type. GAT-mediatedGABA transport...
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Tài liệu Báo cáo khoa học: The role of the SEA (sea urchin sperm protein, enterokinase and agrin) module in cleavage of membrane-tethered mucins pdf
... modeling of SEA domain of MUC1The composer and biopolymer modules of the sybyl 6.91software package (Tripos Inc., St Louis, MO, USA) wereused for comparative molecular modelling of the humanMUC1 ... furtherinvestigate the role of the SEA domain in cleavage of membrane-tethered mucins we carried out site-directedmutagenesis of the FRPG ⁄ SVVV site and evaluatedhybrid mucins in which the SEA module of MUC1was ... in the cleavage site motif,Fig. 3. Model of SEA domain of MUC1. Ribbon representation of the modelled SEA domain of human MUC1. The model consists of three a-helices and six b-strands forming...
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Tài liệu Báo cáo khoa học: Key role of the loop connecting the two beta strands of mussel defensin in its antimicrobial activity docx
... activity of MGD1 is of general value in themechanism of action of defensins. However, our resultscould be compared with results obtained by other groupswho also point to the role of the connecting ... structural feature of the mode of action,although the precise role of the loop was not elucidated.In conclusion, our results indicated that residues 23–35 of mussel defensin MGD1 play a key role in the ... presence of FITC–streptavidin and absence of peptide, and in the presence of FITC–streptavidin and 30 lM of an irrelevantbiotinylated peptide (Biot-YKKWINTFSGVPTYA). (B) Viability of M. lysodeikticus...
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Tài liệu Báo cáo khoa học: Electrostatic role of aromatic ring stacking in the pH-sensitive modulation of a chymotrypsin-type serine protease, Achromobacter protease I pdf
... increased.The effect of the size of the residue at position 169 may berelated to the solvent accessibility of the side-chain of His210 (Fig. 3C). When the accessibility of the side-chain of His210 increased, ... surface areas (ASA) of individual residues in the API variants were calculated withtheINSIGHT II/DISCOVERsoftware. The radius of the solventprobe was 1.4 A˚.Measurement of 1H-NMRThe pH-dependent1H-NMR ... contribution of the electro-static interaction of Asp113–His210, which is supported byTrp169, in the pH-sensitive modulation of activity asunravelled by analysis of the kinetics of single and...
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Tài liệu Báo cáo khoa học: "The Role Of Focussing in Interpretation of Pronouns " pdf
... The Role Of Focussing in Interpretation of Pronouns Candace L. Sidner Artificial Intelligence Laboratory Massachusetts Institute of Technology Cambridge, MA ... the formal relationship between the process of focussing and interpret;ition of pronominal anaphora. The discussion of focussing extends the work of Grosz [1977]. Foct,ssing is defined algorithmical]y ... Agency of the Department of Defense under the Office of Naval Research under Contract Number N00014-73-C4)643. However, their approaches are either simple heuristics which offer no unified treatment...
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Tài liệu Báo cáo khoa học: "The Role of Initiative in Tutorial Dialogue" pdf
... benefit of this annotation scheme is that in ourcorpus the majority of turns can be automaticallylabeled: questions often ended in question marks;commands often started with verbs; a list of ... about financial andsoftware problems. In the TODs, as we wouldexpect, the expert had initiative most of the time(91% of the turns). However, ADs have closer toan equal sharing of initiative — ... expert had ini-tiative for 60% of the turns in finance ADs and51% of the turns in software ADs. This is becausein the ADs, the novice must communicate the de-tails of his problem to the expert...
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Từ khóa: Báo cáo quy trình mua hàng CT CP Công Nghệ NPVNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longThơ nôm tứ tuyệt trào phúng hồ xuân hươngChuong 2 nhận dạng rui roQuản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIĐổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ