Báo cáo khoa học: Differential effects of histone deacetylas

Báo cáo khoa học: Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-b1 induced murine tissue inhibitor of metalloproteinases-1 gene expression docx

... FEBS HDAC inhibitors and Timp-1 expression D. A. Young et al. Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-b1 induced murine tissue inhibitor of metalloproteinases-1 ... on basal expression of Timp-1, only on induced gene expression. In conclusion, this is to our knowledge, the only described instance o...

Ngày tải lên : 16/03/2014, 18:20

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Tài liệu Báo cáo khoa học: Differential effects of Mxi1-SRa and Mxi1-SRb in Myc antagonism ppt

... the onset of foci formation. As such, we generated several expression constructs for Mxi1-SRa containing different lengths of 5¢-UTR, and tested these in in vitro transcription ⁄ translation assays followed ... cotransformation activity in the REF assay. Expression constructs were generated encoding Myc-tagged versions of these two isoforms, as well as of the Mxi1-WR isoform tha...

Ngày tải lên : 18/02/2014, 16:20

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Báo cáo khoa học: Differential effects of RU486 reveal distinct mechanisms for glucocorticoid repression of prostaglandin E2 release docx

... and COX-2 expression (Figs 1 and 2 ). In ad dition, the ability of RU486 to antagonize the repressive effects of 0.1 l M dexamethasone or budesonide was examined. In each case, a concentration-dependent ... [7,14]. Consistent with the combined COX/PGES data, the analysis of COX-2 mRNA and protein expression revealed a concentration-dependent inhibition of COX-2 expression...

Ngày tải lên : 07/03/2014, 16:20

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Báo cáo khoa học: What’s in a covalent bond? On the role and formation of covalently bound flavin cofactors doc

... physiologi- cal and phylogenetic data. Information on the physio- logical fate of the enzyme, e.g. cellular localization and the reaction that is catalyzed, as well as in-depth knowledge of the evolution of ... number of ﬂavin analogs has revealed a Hammett rela- tionship between the electron-donating or electron- withdrawing properties of substituents at positions 7 and 8...

Ngày tải lên : 16/03/2014, 01:20

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Báo cáo khoa học: G protein-coupled receptor 30 down-regulates cofactor expression and interferes with the transcriptional activity of glucocorticoid pdf

... transcriptional activity [5–7], and a r eduction in cofactor TIF2 expression prevents ERa -induced and ligand -induced activation of the promo- ter 3xERE-TATA [9]. Differential expression of cofactors has ... activation of transcription. We established that GPR30 down-regulated the expression of cofactor TIF2. The crucial r ole of cofactors in the activation of trans...

Ngày tải lên : 16/03/2014, 18:20

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Tài liệu Báo cáo khoa học: Structural effects of a dimer interface mutation on catalytic activity of triosephosphate isomerase The role of conserved residues and complementary mutations pptx

... of mutations was conﬁrmed by sequencing (Microsynth, Balgach, Switzerland), and the mutants were found to be free of PCR errors. Protein expression and puriﬁcation Expression of the TIM gene was ... interacts with N10 and E97 of the second subunit. The backbone NH group of R98 forms a hydrogen bond with the backbone CO of F102. Fur- thermore, the orientation of the s...

Ngày tải lên : 18/02/2014, 11:20

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Tài liệu Báo cáo khoa học: Antimicrobial effects of H4-(86–100), histogranin and related compounds – possible involvement of DNA gyrase ppt

... Lemaire S (2004) Correlation between the expression of the histone H4 mRNA variant H4-v.1 and the levels of histone H4-(86–100) and H4-(89–102) (OGP) in various rat tissues and alveolar macrophages. Peptides, ... structure in histone H4 and its fragments. Biochemistry 14, 3391–3400. 30 Bello J, Bello HR & Granados E (1982) Conformation and aggregation of melittin:...

Ngày tải lên : 18/02/2014, 14:20

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Tài liệu Báo cáo khoa học: Mixed lineage leukemia histone methylases play critical roles in estrogen-mediated regulation of HOXC13 docx

... embryogenesis and organo- genesis. The nature of a body structure depends on the speciﬁc combination of HOX gene products, and the expression of speciﬁc HOX genes varies at different stages of development. ... unclear, several hormones have recently been shown to regulate HOX gene expression, and the endocrine regulation of HOX genes appears to allow the generation o...

Ngày tải lên : 18/02/2014, 14:20

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Tài liệu Báo cáo khoa học: Differential expression of duplicated LDH-A genes during temperature acclimation of weatherﬁsh Misgurnus fossilis Functional consequences for the enzyme ppt

... properties (concentration and, as a consequence, total activity) of an enzyme can be chan- ged by affecting rates of transcription and ⁄ or translation and ⁄ or mRNA and protein degradation. This represents ... Authors Journal compilation ª 2007 FEBS 1513 Differential expression of duplicated LDH-A genes during temperature acclimation of weatherﬁsh Misgurnus fossilis Func...

Ngày tải lên : 19/02/2014, 02:20

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Tài liệu Báo cáo khoa học: Inhibitory effects of nontoxic protein volvatoxin A1 on pore-forming cardiotoxic protein volvatoxin A2 by interaction with amphipathic a-helix doc

... the membrane of cells. Inhibitory effects of VVA1 on the hemolytic and cytotoxic activity of VVA2 The effects of VVA1 on the hemolytic activity of VVA2 were studied by incubation of human red ... Rochat H, Harvey AL, Montenay-Garestier T & Menez A (1990) Delineation of the functional site of a snake venom cardiotoxin: preparation, structure, and function of m...

Ngày tải lên : 19/02/2014, 06:20

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