Báo cáo khoa học: Silencing the expression of mitochondrial acyl-CoA thioesterase I and acyl-CoA synthetase 4 inhibits hormone-induced steroidogenesis potx

... FEBS Silencing the expression of mitochondrial acyl-CoA thioesterase I and acyl-CoA synthetase 4 inhibits hormone-induced steroidogenesis Paula Maloberti*, Rocı ´ o Castilla*, Fernanda Castillo, ... shown). This result demonstrates the participation of MTE -I in the regulation of the rate-limiting step in steroidogenesis. To provide additional insigh...

Ngày tải lên: 16/03/2014, 18:20

... recursive partitioning; the splitting criterion was reduction in deviance. Using the Gini index led to larger trees and higher misclassification rates. Since the primary purpose of the trees was ... or infinitive clauses, has been ex- amined selectively in quantitative stylistics. In his comparative analysis of written and spoken genres in English, Biber (Biber, 1988) l...

Ngày tải lên: 22/02/2014, 03:20

... Takeshi Yamazaki 4 , Ken-ichi Tanamoto 4 , Haruo Matsuda 5 , Jun-ichi Sawada 2 and Kosuke Takatori 1 1 Division of Microbiology, National Institute of Health Sciences, Tokyo, Japan 2 Division of Biochemistry ... regu- lates GPI ) PrPSV expression, and its relationship with the expression level of GPI ) PrPSV and prion diseases requires further investigation. Experimenta...

Ngày tải lên: 30/03/2014, 04:20

... eukaryotic Sco proteins indicate that, despite the full conservation of the three metal-binding ligands, the metal-binding site has an intrinsic structural flexibility, indicating the absence of a binding ... metal addition. The cysteine ligands are shown in yellow, the histidine ligand in blue, and the Cu (I) ion in light blue. Determinants of the elusive functions of...

Ngày tải lên: 14/02/2014, 18:20

... UDPGlcNAc, and the assay was initiated by addition of these two nucleotides. Where indicated, the assay was initiated by the addition of the enzyme preparation to an otherwise complete assay mixture. The ... 15% of the initial inhibitory activity in the fraction eluted with 500 mm NaCl. As this inhibitory fraction contained CoASH, we tested the effect of this nucleot...

Ngày tải lên: 19/02/2014, 07:20

... biosyn- thesis by the action of cycloheximide. Cycloheximide binds to the 80S-subunit o f eukaryotic ribosomes and prevents the initiation and elongation reaction of protein biosynthesis. The mycelium ... diminishes polyketide synthesis or whether a direct interaction of propionyl-CoA with polyketide s ynthetase i s responsible for this effect. Succinyl-CoA synthetase is...

Ngày tải lên: 19/02/2014, 16:20

... consider the reorder- ing of an argument as the motion of the argument relative to its predicate. In particular, we use the po- sition of the predicate as the reference axis. The mo- tion of associated ... es- timate positions of its associated arguments on the target side. In this way, the model predicts moving directions of arguments relative to their predicate...

Ngày tải lên: 19/02/2014, 19:20

... supervised and unsupervised. 5 Identifiability error While approximation error is incurred when likeli- hood diverges from accuracy, identifiability error is concerned with the case where likelihood is indiffer- ent ... the set of maximizers of E log p θ (x) is non-identifiable. 8 Label symmetry is perhaps the most familiar ex- ample of non-identifiability and is intrinsic to mod-...

Ngày tải lên: 20/02/2014, 09:20

... undirected graphical models that encode a conditional probability distribution using a given set of features. CRFs allow both discriminative training and bi-directional flow of probabilistic in- formation ... solved without approximation. 4 Reduction of Training/Inference Cost The straightforward implementation of this mod- eling in semi-CRFs often results in a prohibitive comput...

Ngày tải lên: 20/02/2014, 12:20

... constructions, particularly comparatives and equatives, is limited because of the lack of fine-grained subcategorization infor- mation in the PoS tags and by the need to balance depth of analysis against ... multiple tag possibilities per word as in- put to the parser, by incorporating lexical subcate- gorization into parse selection, by computing GR weights based on the pr...

Ngày tải lên: 20/02/2014, 12:20