Báo cáo khoa học: 14-3-3 Proteins regulate glycogen synthase 3b phosphorylation and inhibit cardiomyocyte hypertrophy doc

... NY. 14-3-3 Controls cardiomyocyte hypertrophy through GSK3b W. Liao et al. 1854 FEBS Journal 272 (2005) 1845–1854 ª 2005 FEBS 14-3-3 Proteins regulate glycogen synthase 3b phosphorylation and inhibit ... protein kinase B, PKB) at Ser473 and glycogen synthase 3b (GSK3b) at Ser9, but not extracellular signal-regulated kinase 1 ⁄ 2 (ERK1 ⁄ 2). AdR18-induced PKB a...

Ngày tải lên: 16/03/2014, 18:20

... Hg 2+ [12,13], Pb 2+ [14], and UO 2 2+ [15]; and constructing molecular logic gates and nanomotors [16–20]. How- ever, engineering an allosteric DNAzyme with dual RNA-cleaving and DNA-cleaving activities ... lM L -ascorbate (except for PL–), and 30 mM Hepes at 23 °C. PL+ and PL) represent the presence and absence, respectively, of L-ascorbate in the reaction. Lanes M I and M I...

Ngày tải lên: 16/02/2014, 15:20

... ERK1 ⁄ 2 phosphorylation was detected rapidly and was tran- sient; phosphorylation of ERK1 ⁄ 2 was induced within 10 min and phosphorylation was back to basal levels by 60 min, unlike phosphorylation ... in phosphorylation states of Akt (T308 and S473 sites) and S6K1 (T389 and T421 ⁄ S424 sites) were determined. (B) Subcellular distributions of TSC1 ⁄ TSC2 proteins were...

Ngày tải lên: 15/03/2014, 11:20

... muscle enzyme and the catalytic subunit of S. cerevisiae,andthePP i -depen- dent enzymes of E. histolytica, A. methanolica and P. freundenreichii. Sequences of yeast and human expanding beyond ... and regulatory sites, among the various available structures of E. coli and Bacillus stearothermophilus PFK, as this 4pfk structure contains fructose 6-phosphate and ADP in the active si...

Ngày tải lên: 23/03/2014, 21:21

... are identified: with and without commas (“Rupert Murdoch, News Corp.’s chairman and chief ex- ecutive officer,” and “News Corp.’s chairman and chief executive officer Rupert Murdoch”). In the MUC-7 ... discourse and the hearer givenness.The resulting taxonomy is summarised below: brand new NPs introduce entities which are both discourse and hearer new (“a bus”), sub- class of them, b...

Ngày tải lên: 31/03/2014, 03:20

... M33S and isoform 1 proteins were secreted into the conditioned media by mouse neuroblastoma, Neuro2a, or COS cells (Fig. 4C and S. Mitsui, unpublished results). The secreted M33S and isoform 2 proteins ... salivary gland; TG, thyroid gland; MG, mammary gland; Pa, pancreas; Lu, lung; Pr, prostate; Te, testis. Fig. 1. Nucleotide sequences of human and mouse KLK11 promoter regions. (...

Ngày tải lên: 19/02/2014, 06:20

... visualized using excitation and emission wavelengths of 485 and 530 nm, respectively, for YFP, and DAPI fluorescence was visualized by excitation with UV light (355 nm) and detected at 450 nm. The ... Research Fund (OTKA K68229 and CK-78646), the Howard Hughes Medical Institute (55005628 and 55000342), the Alexander von Humboldt Foundation, the National Office for Research and Tec...

Ngày tải lên: 15/03/2014, 11:20

... Automated docking of substrates to proteins by simulated annealing. Proteins 8, 195–202. 40 Goodsell DS, Morris GM & Olson AJ (1996) Auto- mated docking of flexible ligands: applications of auto- dock. ... 140 and 42 using Xtal- View ⁄ Xfit [42] and ⁄ or MIFit (Rigaku Americas Corp.). All water and acetate atoms were removed. Hydrogen atoms were added to the crystal structure, an...

Ngày tải lên: 15/03/2014, 11:20

... activity of KCTD10; and SP1 and AP-2a can regulate the promoter activity and endogenous KCTD10 expression oppositely through binding this region. Results Analysis of genomic structure and identification of ... proliferating cell nuclear antigen and the small subunit of polymerase d, and to have roles in DNA repair, DNA replication and cell-cycle control. To better understand th...

Ngày tải lên: 30/03/2014, 02:20

... was associated with inactivation of glycogen synthase and inhibition of glycogen synthesis. The rate of glycogen synthesis, but not the activity of glycogen synthase, inversely correlated with ... determination of glycogen synthesis and the activities of phosphorylase-a and glycogen synthase. (A) Phos- phorylase-a. (B) Active glycogen synthase versus phosphorylase-a....

Ngày tải lên: 30/03/2014, 11:20