Báo cáo khoa học: Transcriptional responses to glucose at different glycolytic rates in Saccharomyces cerevisiae ppt

... expression at high glycolytic rates, but sti-mulated SUC2 expression at low glycolytic rates. Thissuggests that Mig1-mediated repression can be overruled byfactors mediating induction via a low glucose ... concentration of glucose, while thelevel of phosphorylated Snf1 was increased in cells shifted to a low concentration of glucose. In the HXT-null strain,Mig1 migrated at an intermediate rate (high glucose) ... either by minute amounts of glucose diffusing into cells of the HXT-null strain or to signalling pathways sensing external glucose, such as theGpr1-PKA pathway. That signalling is t riggered inside...

Báo cáo khoa học: Dynamin-like protein-dependent formation of Woronin bodies in Saccharomyces cerevisiae upon heterologous expression of a single protein pdf

... orspherical [1]. Although intriguing, this observationpoints to the existence of additional factors in ﬁlamen-tous fungi that contribute to the formation of matureand functional Woronin bodies.Although ... cellslacking Vps1p and Dnm1p, dynamin-like proteins required for the divisionof peroxisomes, the Woronin-body-like organelles remained attached to peroxisomes. The data indicate that Woronin bodies ... in the supernatantfractions. These data indicated that a typical HEX1crystal core was formed in yeast which is likely to contain only minor inclusions of peroxisomal matrixproteins.Vps1p and...

Tài liệu Báo cáo khoa học: Chemical approaches to mapping the function of post-translational modiﬁcations ppt

... used to model the P-selectin-bindingdomain of the mucin-like glycoprotein PSGL-1 [73,74].This ligand is involved in the initial homing of leuko-cytes to sites of in ammation [73,74]. The binding ... chronic in ammation in mammalian brain tissue both in vitro and in vivo,including in the detection of cerebral malaria.Retooling of this reporter system also allowed sys-tematic investigation ... modiﬁcations converted the proteaseSBL into an improved biocatalyst in peptide ligation.Particularly striking was the broad substrate tolerancethat could be engineered (e.g. towards non-naturalamino...

Báo cáo khoa học: "Using WordNet to Automatically Deduce Relations between Words in Noun-Noun Compounds" docx

... providing a set of com-pounds to use as input for our compound disam-biguation algorithm, one aim in constructing thiscorpus was to examine the relations that exist in naturally occurring noun-noun ... commonly-occuring relations were also observed. To allowfor these other relations, a function was added to the web page allowing the annotator to enter theappropriate relation appearing in the form ... Selecting relation and relation senses.allowing the annotator to identify the correct se-mantic relation for that compound, and then to se-lect the correct WordNet sense for the verb in thatrelation.We...

Báo cáo khoa học: "Discriminative Approach to Predicate-Argument Structure Analysis with Zero-Anaphora Resolution" pptx

... assign generation probabilities to NULLs. Re-garding the training corpus that will be described in Section 3, the NULL rates of the nominative,accusative, and dative cases were 16.7%, 59.9%,and ... claim and add two different kinds of features. One is the feature thatindicates whether a candidate has been used as anargument of predicates in the preceding sentences(‘Used’ features). However, ... articles. We dividedthem into training, development, and test sets asshown in Table 2.Argument Identiﬁcation Models: Maximumentropy models were trained using the training set. In these experiments,...

Báo cáo khóa học: Genetic approaches to the cellular functions of polyamines in mammals potx

... ofproliferation indicators, the transgenic rats failed to initiateliver regeneration in striking contrast to their syngeniclittermates [113]. Only when hepatic spermidine concentra-tion was increased ... translated to clinical practice apparently due to the sophisticated compensatory mechanisms aimed at maintaining polyamine homeostasis [25,26]. In fact, poly-amines may have a dual role in cellular ... welldocumented role in the induction of seizure activity [63] andmediating spatial encoding [64]. The ﬁnding indicating thatthe transcript levels of several neurotrophins were elevated in the brain of the...

Báo cáo khoa học: "Using Restriction to Extend Parsing Algorithms for Complex-Feature-Based Formalisms" pptx

... domain of atomic elements to a possibly infinite domain of directed graph structures nf a certain sort. Unfortunately, in moving to an infinite nonterminal domain, standard methods of parsing ... structuring the major category itself (say into binary N and V features plus a bar-level feature as in ~-based theo- ries). F.rcing the primacy and atomicity of major category defeats part ... Thus, if information about subcategorization is left out of the category information in the context-free skeleton, it can- not be used to eliminate prediction edges. For example, if we find a...

Tài liệu Báo cáo khoa học: Differential effects of Mxi1-SRa and Mxi1-SRb in Myc antagonism ppt

... patterns were also observed, includ-ing that Mxi1-SRa appears to be the predominanttranscript in the adult intestine and in the developingembryo, whereas Mxi1-SRb transcripts predominate in the ... tran-scription of histone H2B promoter [20]. Thus, it istempting to speculate that Mxi1-SRa may be able to recruit coactivator complexes containing GAPDH to speciﬁc target genes resulting in activation. More ... Regardingthe latter, it is interesting to note that the Mxi1-SRaisoform (also known as Mxi1-0) was cloned initially asa gene up-regulated in a neuroblastoma cell line.Moreover, in that study,...

Tài liệu Báo cáo khoa học: Bacterial-induced hepoxilin A3 secretion as a pro-inﬂammatory mediator pptx

... meta-bolism involved in the events underlying in ammation,such observations further underscore an emerging con-cept suggesting that modulation of the 12-LOX path-way during intestinal in ammation ... However, basolateral IL-8 release is insufﬁ-cient to induce the migration of neutrophils across theintestinal epithelium, suggesting that the production ofother in ammatory mediators, whose ... interstitium (lung) and epithelium, in response to localized in ammatory mediators. Overall,such directed migration of neutrophils involves theintegrated actions of cytokines, adhesion moleculeswith...

Tài liệu Báo cáo khoa học: The small heat shock proteins and their role in human disease pptx

... a-crystallin domainarginines. R120G aB-crystallin permits intermediate ﬁl-ament self association in vitro, although binding of themodiﬁed protein to ﬁlaments increases in comparison to wild-type ... reduced chaperoning links trun-cation to cataract. a-crystallin deamidation involvesthe nonenzymatic conversion of asparagine to eitheraspartate or isoaspartate, and glutamine becomesglutamic ... aA-crystallin to Hsp27 and aB-crystallinincreases in comparison to wild type, while binding to cC-crystallin and bB2-crystallin decreases. Reaction ofR120G aB-crystallin with bB2-crystallin is moderatelyenhanced,...

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