Báo cáo khoa học: The Rab5 effector Rabaptin-5 and its isoform Rabaptin-5d differ in their ability to interact with the small GTPase Rab4 doc

... FEBS Journal 272 (2005) 37–46 ª 2004 FEBS The Rab5 effector Rabaptin-5 and its isoform Rabaptin-5d differ in their ability to interact with the small GTPase Rab4 Elena Korobko 1,2 , Sergey Kiselev 1 , ... August 2004) doi:10.1111/j.1432-1033.2004.04399.x Rabaptin-5 is an effector for the small GTPase Rab5, a regulator of the early steps in...

Ngày tải lên: 16/03/2014, 18:20

... 551 Results Cloning of the genes, hadI and hadBC The genes, hadI for activator or initiator and hadBC for the two subunits of the dehydratase, were identified in the gene cluster of the putative ... experi- ments indicated that the low dehydratase ⁄ activator ratio £ 1 required to get high activity was due to the instability of the activator in the assay mixture...

Ngày tải lên: 07/03/2014, 16:20

... regulated independently by the main fuel sources in muscle and by insulin through directly altering the expression of the human PDK2 and PDK4 isoforms. In addition to our findings, insulin has been ... established as an insulin-sensitive target pro- tein [30]. Incubation of myoblasts with the mTOR- selective inhibitor rapamycin (100 nm) for 5 h was employed to further elu...

Ngày tải lên: 07/03/2014, 17:20

... function tags. To simplify the system build- ing, we take the first tag in training and testing and report the aggregated accuracy only in this section. #-sents #-nodes #-funcNodes training 71,186 ... contributions of different feature groups by incrementally adding features into the system, and the results are reported in Table 5. The dummy baseline is predicting th...

Ngày tải lên: 07/03/2014, 22:20

... finite-state automaton starting from the beginning of the sentence and passing to the right until it finds an input configuration on which it can operate by deletion of some parts of the input. Having performed ... ambiguities occur within a paradigm, i.e. they are common to all lexemes belonging to a particular in ection class. For example, in Czech (as in many other in-...

Ngày tải lên: 08/03/2014, 05:20

... that in these trypanosomatid proteins, the ankyrin repeat structures are involved in establishing interactions between proteins. However, it remains to be determined with which proteins. Known interaction ... PFK-2 and FBPase-2 domains in the C-terminal halves of the proteins are indicated as in Fig. 2. In the N-terminal halves, the ankyrin motifs with a primary st...

Ngày tải lên: 16/03/2014, 22:20

... sug- gesting that the corresponding gene products were complementing the deficient strain. In these two strains succinate is converted into fumarate and then oxidized to malate. The latter is further ... citrate) into pyruvate in the presence of divalent metals and in the absence of nicotinamide cofactors [7]. Noteworthy, the activity of MEF proteins contribute to th...

Ngày tải lên: 22/03/2014, 16:20

... relations between the subordinate clause and the main clause This information is used to determine the scope of negation in the main clause. In the subordinate clause with the conjunctive particle ... Following the conjunctive analysis between the subordinate clause and the main clause, this module is activated to determine whether the modality in th...

Ngày tải lên: 24/03/2014, 01:21

... that tau interacts with Fyn-SH2. Proteins harbouring SH2 domains bind to phosphorylated tyrosines on their tar- get proteins, thereby coupling the activity of tyrosine kinases with intracellular ... tyrosines present on tau [17–19], and tau also interacts with Fyn via its Src homology (SH)3 domain [20,21]. The SH3 domain of Fyn binds to proline-rich motifs within the seq...

Ngày tải lên: 14/02/2014, 14:20

... the sub- strate and the highly charged active site [19,20]. In contrast to the findings with Yop51 and PTP1, increas- ing the ionic strength from 100 to 500 mm enhanced the binding of InsP 6 to ... being inactivated after 10 min of treatment and 65% being inactivated after 30 min. Incubation of the enzyme for up to an hour with 100 lm H 2 O 2 did not further ina...

Ngày tải lên: 18/02/2014, 18:20