Báo cáo khoa học: Solution structure of 2¢,5¢ d(G4C4) Relevance to topological restrictions and nature’s choice of phosphodiester links docx

... al. (Eur. J. Biochem. 271) Ó FEBS 2004 Solution structure of 2¢,5¢ d(G 4 C 4 ) Relevance to topological restrictions and nature’s choice of phosphodiester links Bernard J. Premraj 1 , Swaminathan ... relating to the optimization of t opological features might have been a factor in the rejection of 2¢,5¢ links in preferenc e to 3¢,5¢ link s. Keywords: s...

Ngày tải lên: 16/03/2014, 18:20

... interactions to understand the efficient cytotoxic activity of HtA. The contributions of the N-terminal hairpin, loop 2 and loop 5 with regard to protein functionality, protein– protein and protein–lipid ... ribotoxins and less specific microbial RNases, and thus offers a unique chance to determine the minimal structural requirements for activities unique to ribotoxins. Here...

Ngày tải lên: 18/02/2014, 08:20

... helix and strand b 1 and has its correspondent in Gly31, belonging to the loop that connects the a-helix to strand b 2 of AaHII. This can be Fig. 5. Solution structure of crotamine. Stereo view of ... plotted as a function of residue number. Top: number of interproton distance constraints; bottom: rmsd values for backbone (bars) and heavy (line) atoms. Ó FEBS 2003 NMR...

Ngày tải lên: 20/02/2014, 11:20

... the side chains of five residues, V20, R22, Y34, R44, and S45 [19]. Although the solution structure of the core region of the MBD of MeCP2 has been determined and some essentials of its interaction ... several arginine and lysine side chains forming hydrogen bonds with the bases and contacting the DNA backbone. The solution structure of the MBD of MBD1 shows high...

Ngày tải lên: 21/02/2014, 00:20

... domains of goldfish RICH (gRICH68), human and rat CNPase (hCNP and rCNP, respectively) and a homologous protein from puffer fish (Gi:47207595). The secondary structure elements refer to the solution structure ... Leu175 to Phe386 and presents its N- and C-termini together close in space. This would position the N-terminal domain of full-length RICH protein relatively clo...

Ngày tải lên: 07/03/2014, 10:20

... ratio of the s tandard deviations of the chemical shifts of the amide nitrogen and p roton nuclei. Results Determination of the three-dimensional structure of HPr(I14A) To allow the comparison of ... protons of Leu86 and protons of amino acids Ala14, Val55 and Leu81 are observed, none of which are seen for the wild-type protein. Analysis of the backbone dihedral...

Ngày tải lên: 07/03/2014, 16:20

... hHR23B and hHR23A are shown. Also, b-N and b-C are the N- and C-termini of XPCB–hHR23B; a-N and a-C are the N- and C-termini of hHR23A. B. Kim et al. Dynamic structure of XPC-binding domain of hHR23B FEBS ... because of the high content of Gln, Leu and Glu, we were able to accomplish complete side-chain assignment with the aid of additional HCCH-COSY spectrum. Af...

Ngày tải lên: 07/03/2014, 17:20

... C a -atomic coordinate comparison of our solution structure of human PDI-bb¢ and the crys- tal structure of the I289A mutant of the human PDI- b¢x fragment [16] showed differences with an rmsd of 2.6 ... degra- dation of the substrate tRNA. Both mastoparan and D-somatostatin blocked refolding. Fig. 6. NMR titrations of 2 mM mastoparan by human PDI-bb¢ protein and a p...

Ngày tải lên: 16/03/2014, 04:20

... structurally related b-domain of mouse MT1 and human MT2 a re 0.57 and 2.10 A ˚ for the backbone heavy atoms and the sulfur atoms, respectively. Discussion The solution structure of the Cu 6 NcMT, which ... Ribbon diagram of the NMR solution structure o f NcMT with six Cu(I ) atoms modelled into possible positions within th e structure and the cysteine side chains turn...

Ngày tải lên: 23/03/2014, 13:20

... neurotoxins. TheNMRstructureofNTX-1isclosesttothatofthe a-cobratoxin crystal. The superposition of these two structures shows an RMSD value of 3.00 A ˚ for all backbone atoms which reduces to 1.4 ... Arg35, Lys37 and His67 play an important role in receptor b inding and hence in the toxicity of neurotoxins [1,2,6,8]. Already the crystal and solution structures of some long n...

Ngày tải lên: 23/03/2014, 13:20