... proteins involved in retinoid-related metabolism (retinoic acid receptors, cellular binding proteins and oxidizing enzymes) have been mapped within the adult dopamine system [35]. In the adult ... in human [9], and by immunohisto- chemistry also in rodents [22]. Expression of ADH3 in the adult rodent and human brain Overviews of the expression patterns of...
Ngày tải lên: 21/02/2014, 00:20
... repre- sent the last subunits incorporated into the bc 1 com- plex. On the other hand, the absence of Qcr9p in the DQCR9 ⁄ DQCR10 strain prevented the binding of ISP (Fig. 4B). Interestingly, in the ... addition of ISP and Qcr10p). On the other hand, in the transition from the 500 kDa band to the 670 kDa band, a structural rearrangement of the bc 1 comp...
Ngày tải lên: 18/02/2014, 08:20
Tài liệu Báo cáo khoa học: Looking for the ancestry of the heavy-chain subunits of heteromeric amino acid transporters rBAT and 4F2hc within the GH13 a-amylase family ppt
... barrel domain, including domain B and the C-terminal domain C for rBAT proteins (669 residues on average); (b) the cata- lytic TIM barrel domain, including domain B and the C-terminal domain C for ... is the lack of domain B protruding out of the TIM barrel in the place of loop 3 connecting the b3-strand to the a3-helix [9,21]. Sharing domain B by rBATs and GH13...
Ngày tải lên: 18/02/2014, 13:20
Tài liệu Báo cáo khoa học: Acetylcholinesterase from the invertebrate Ciona intestinalis is capable of assembling into asymmetric forms when co-expressed with vertebrate collagenic tail peptide doc
... with the PRAD domain of ColQ indicates that the WAT domain of the C. intestinalis AChE is capable of organizing the sub- units into a tetramer through interaction with the PRAD domain of ColQ. The ... from C. intestinalis expressed in vitro and native enzyme expressed in vivo indicates the enzyme is AChE To determine the nature of the cholinesterase activity...
Ngày tải lên: 18/02/2014, 17:20
Tài liệu Báo cáo khoa học: Insights into the structure of plant a-type phospholipase D Susanne Stumpe, Stephan Konig and Renate Ulbrich-Hofmann ¨ ppt
... similar- ity in the remaining parts of the molecules. Most mam- malian PLDs contain a PX and a PH domain instead of the C2 domain in plants, whereas microbial PLDs lack such probably regulatory domains. Despite ... responsible for the calcium binding [8], we hypothesize that this bind- ing event takes place at the C2 domain. A second calcium-binding site of lower affinity...
Ngày tải lên: 19/02/2014, 02:20
Tài liệu Báo cáo khoa học: Hypoxia reduces the expression of heme oxygenase-2 in various types of human cell lines A possible strategy for the maintenance of intracellular heme level pdf
... hypoxia on HO-1 and HO-2 expression in human cell lines We initially analyzed the effects of hypoxia on the expression of HO-1 and HO-2 in human cell lines of bone marrow origin, including KG1 myeloid ... the intensity for the a-tubulin signal. Shown are the relative expression levels of HO-1 and HO-2 proteins in YN-1 cells (B) and those of HO-2 protein in...
Ngày tải lên: 19/02/2014, 06:20
Tài liệu Báo cáo khoa học: Enzymes for the NADPH-dependent reduction of dihydroxyacetone and D-glyceraldehyde and L-glyceraldehyde in the mould Hypocrea jecorina doc
... activity in crude yeast extract as the untagged protein, indicating that the tag was not interfering with the protein activity. The tagged protein was purified and then used for further analysis. In the ... nkatÆmg )1 . The GLD1 pro- tein was tagged with a histidine tag at the N-terminal end by adding the coding sequence for six histidines to the end of the open rea...
Ngày tải lên: 19/02/2014, 06:20
Tài liệu Báo cáo khoa học: nsights into the reaction mechanism of glycosyl hydrolase family 49 Site-directed mutagenesis and substrate preference of isopullulanase doc
... 20–564), and the model is composed of residues 25–540. The overall structure of the model of IPU and the mutated residues in this study are shown in Fig. 3. To elucidate the mechanism of the substrate ... of 3.2) [45] was a solution in the Dali result. It is likely that the inte rface between N-terminal and b-he lical domains participate in binding of...
Ngày tải lên: 19/02/2014, 16:20
Tài liệu Báo cáo khoa học: An immunomodulator used to protect young in the pouch of the Tammar wallaby, Macropus eugenii pptx
... activa- tion of CCK receptors stimulate production of inter- leukins and secretion of immunoglobulins on the mucosal surface of the intestine [49,50]. The antibacte- rial defence of the intestinal mucosa ... reduced the response to euge- nin, indicating that eugenin is indeed acting through CCK 2 receptors. To further investigate the interaction of eugenin with CCK 2...
Ngày tải lên: 19/02/2014, 16:20
Tài liệu Báo cáo khoa học: Insights into the interaction of human arginase II with substrate and manganese ions by site-directed mutagenesis and kinetic studies Alteration of substrate specificity by replacement of Asn149 with Asp docx
... known to be involved in binding and hydrolysis of the guanidino group of l-arginine by arginase are strictly conserved in the act- ive site of the agmatinases [19]. Moreover, modeling studies ... by agmatine hydrolysis, in studying the inhibitory effect of agmatine on arginine hydrolysis, reactions were followed by measuring the formation of ornithine, determined b...
Ngày tải lên: 20/02/2014, 02:21