... IL-6 and Il-10may contribute to osteopenia, IL-1b, TNFa and IL-6 maycontribute to activation of coagulation and hypermetabolism,IL-6 and IL-10 to gammopathies (Brautbar et al, 2004) and MM ... feeling in the medical and research community thatthere is little need to understand the basic mechanisms ofdisease development and progression. However, a renewedinterest in GD, and in the biology ... involved in development of diseasepathology (Futerman & van Meer, 2004), and then discussdisease management and possible new therapeutic options, anumber of which have been proposed over...