... Kaneko1, Yuanying Ding1, Kazuhiro Ogawa2,*,Miki Yoshizawa1, Masaki Kawamura1, Kazuhisa Takeda1, Tadashi Yoshida3 and Shigeki Shibahara11 Department of Molecular Biology and Applied ... HepG2 and HeLa cellswere cultured for 48 h under normoxia or hypoxia, and then harves-ted. The microsome fraction was prepared and used for the assay of HO activity. The data are means ± SEM of ... norm-oxia (Fig. 6A, C), and was shortened to 6 h under hyp-oxia. The decreased levels of HO-2 mRNA may be in part due to the enhanced degradation of the HO-2mRNA.Functional analysis of the HO-1 and...