Báo cáo khóa học: GTP cyclohydrolase I utilizes metal-free GTP as its substrate pot

... carp HDL resides in its major apolipoproteins (apoA -I and apoA-II) and in addition to determine if a syn thetic peptide derive from apoA -I sequence could display a similar activity. Materials and ... polypeptides (e.g. cathelicidins) [25,26]. Therefore we synthesized this C-ter minal peptide and evaluated its antimicrobial activity in vitro.The synthetic peptide was active against P....

Ngày tải lên: 16/03/2014, 18:20

... Accordingly, an additional inhibition assay was performed using P. falciparum protein extracts and including cathepsin D (an aspartic protease) and the aspartic protease inhibitor pepstatin A as ... metalloprotease inhibi- tion. It is worth stressing that in silico target screening of MA did not point to any protease or peptidase as potential target for MA. Considering the increasing body...

Ngày tải lên: 14/02/2014, 14:20

... PhyK is also found in AppA. The histidine side chain is fixed in its position by Ser96 or Asp88, respectively, whereas the histidine is bridged with the scissile phosphate group. There is a single hydrogen ... in habitat and substrate availability thus gave rise to enzymes with different substrate- binding modes, specificities and kinetics. Abbreviations G1P, glucose-1-phosphatase; HAP, hi...

Ngày tải lên: 16/02/2014, 09:20

... bis-tetrahydrofuranylurethane- containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro. Antimicrob Agents Chemother ... sodium ions, three chloride, two partial acetate ions in PR I5 4M –APV; 19 iodide ions in PR I5 4V –APV; 33 iodide ions in PR I8 4V –APV; and 19 iodide ions in PR L90M – APV. Ho...

Ngày tải lên: 18/02/2014, 04:20

... oxidase; HABA, 2-(4-hydroxyphenylazo)benzoic acid; IT, ion trap; LSAO, lentil (Lens esculenta) amine oxidase; MALDI, matrix-assisted laser desorption/ionization; OVAO, sainfoin (Onobrychis viciifolia) ... specific tyrosine residue that requires both active site copper and molecular o xygen [2]. T he k ey step i n the oxidative deamination is conversion of the initial substrate Schiff base...

Ngày tải lên: 19/02/2014, 16:20

... blocking the PPase activated PP i hydrolysis, as the native PPases in L3 extracts were found to be very sensitive to inhibition by NaF (Fig. 6A). As IDP interferes with the colorimetric assay, it ... P i Æmin )1 Æmg )1 protein for PP i hydrolysis. Anti-(mouse rAsPPase) IgG partially inhibited recombinant AsPPase (6 ng) activity up to 22% in the presence of 5 lgÆmL )1 anti-(mouse rAs...

Ngày tải lên: 20/02/2014, 11:20

... Text Input Front-end Processor as an Information Access Platform Shinichi DOI, Shin-ichiro KAMEI and Kiyoshi YAMABANA C&C Media Research Laboratories, NEC Corporation 4-1-1, Miyazaki, Miyamae-ku, ... retrieve information relevant to the input texts. This information is displayed for easy editing and utilization. Because all of this can be achieved with standard hooks and the IME A...

Ngày tải lên: 20/02/2014, 18:20

... C-terminal cytosolic domain of SR-BI which is a critical domain involved in selective CE-uptake [29,53] is lacking in SR-BII and the lack of SR-BII protein in all three choriocarcinoma cell lines investigated ... and/or steroidogenic tissues. As HDL may exert biological action in human trophoblast cells [50] we have investigated binding, cell association, and holoparticle association of HDL...

Ngày tải lên: 20/02/2014, 23:20

... interpretation of the minimality criterion. In the mid-nineties, the associated debate of computational efficiency versus minimality of the elements appearing in the resulting referring 103 expression ... descriptors is still available. Then the variant which is evaluated worse (in terms of number of descriptors) is discarded. This step is justified by the compositionality in mapping descript...

Ngày tải lên: 22/02/2014, 02:20

... 3: Discounted Trigram Frequencies in the CMU- Cambridge Language Model (a) Duration of Pauses with Continuer II IIIIIIIIIIIIIIuI  0.0 0.3 0.6 0.9 1.2 1.5 1.8 2.1 2.4 2.7 3.0 Duration in seconds (b) ... aim of this model was to see if increasing the num- ber of factors used in prediction would significantly im- prove the coverage whilst also maintaining a high ac- curacy. A continuer was in...

Ngày tải lên: 22/02/2014, 02:20