Báo cáo khoa học: An inserted loop region of stromal ascorbate peroxidase is involved in its hydrogen peroxide-mediated inactivation pot

... An inserted loop region of stromal ascorbate peroxidase is involved in its hydrogen peroxide-mediated inactivation Sakihito Kitajima 1 *, Ken-ichi Tomizawa 1 , Shigeru Shigeoka 2 and Akiho ... peroxidases in which regions of ascorbate peroxidase B, from sites internal to the C-terminal end, were exchanged with corresponding regions of the stromal asc...

Ngày tải lên: 16/03/2014, 14:20

... December 2006) doi:10.1111/j.1742-4658.2007.05652.x (S)-Stylopine is an important intermediate in the biosynthesis of benzophe- nanthridine alkaloids, such as sanguinarine. Stylopine biosynthesis involves the sequential formation of two methylenedioxy ... pathway for a variety of isoquinoline alkaloids. (S)-Scoulerine is an intermediate at the branch point leading to benzophe-...

Ngày tải lên: 07/03/2014, 10:20

... activity is known to need regulatory cofactors, including NoxO1, NoxA1 and Rac1 [5]. The most well-studied activation of Nox1 is that of angiotensin II mediating phospholi- pase C and protein kinase ... that GSK3b is a very important factor in b-catenin signal- ing. In other words, LPS inactivates GSK3b through phosphorylation, and the inactivated GSK3b inhibits the degradation...

Ngày tải lên: 22/03/2014, 21:21

... oligo- saccharide-binding (OB) domain and the additional N- and C-terminal regions in PolC and DnaE, respec- tively. The PolC proofreading 3¢–5¢ exonuclease domain is inserted into the PHP domain and is an integral ... this interaction is unknown. We propose that the PolC N-terminus is involved in mediating the PolC-s interaction and possi- bly also in binding DNA. Introdu...

Ngày tải lên: 05/03/2014, 23:20

... the introduced muta- tions on the lipid- and the enzyme-binding of this cofactor, we combined a variety of functional and bio- physical analyses. Crystallographic analysis of the homodimeric iso- enzyme ... a-helical region of GM2AP as the major determinant in interacting with the enzyme. Our data further confirm conclusively the critical importance of distinct protein–protein in...

Ngày tải lên: 07/03/2014, 12:20

... information collocations non-collocations linear discriminant Figure 2: Data visualization in two dimensions. The dashed line denotes a linear discriminant obtained by logistic linear regres- sion. By moving this boundary we can tune ... – an essential linguistic phenomenon hav- ing a wide spectrum of applications in the field of natural language processing. The core of the work i...

Ngày tải lên: 08/03/2014, 04:22

... for English. The analogous construction (4.b) is also possible in Spanish. A solution, considered by Rizzi to explain the gram- maticality of (4), is to assume that in Italian and Spanish, COMP ... LL(1), and incorporates a stack depth bound which is linearly related to the length of the input string. Prolog's backtracking mechanism provides the means for obtaining a...

Ngày tải lên: 08/03/2014, 18:20

... important amino acid residues lining these pockets. The active site amino acid residues involved in substrate b inding were con served in Pf MDH but the N-terminal glycine motif, which is involved in ... which f orms a d istant loop due to the insertion of five amino acids [14,15]. The N-terminal glycine motif GXGXXG is similar to the cofactor binding motif found in most o...

Ngày tải lên: 16/03/2014, 18:20

... constants of unfolding of wild-type RNase A and its variants were determined. Owing to the isomerization of natively cis proline peptide bonds in the unfolded state [34,35] refolding of RNase A is known ... destabilization of the native state relative to the transition state, underlining the predominant importance of this region for maintaining the natively folded structur...

Ngày tải lên: 16/03/2014, 18:20

... increasing decision power for processing flow, in cases of dialogue segment type with which it is familiar. The intended contribution of this work is thus in the generic definition of standard ... dialogues in which a human is talking to a computer. One dimension distinguishing the three examples is the agent's intelligent use of context. In a dia- logue w...

Ngày tải lên: 17/03/2014, 07:20