Báo cáo khoa học: Recognition of DNA modiﬁed by trans-[PtCl2NH3(4hydroxymethylpyridine)] by tumor suppressor protein p53 and character of DNA adducts of this cytotoxic complex potx

... some aspects of DNA modiﬁcation by trans-PtHMP and how this modiﬁca-tion affects recognition by tumor suppressor protein p53 of the consensus nucleotide sequence to which this protein speciﬁcally ... in DNA by the adducts of BBR3464 and cisplatin pro-duce differential responses to p53 protein activation and recognition. It is therefore of great interest toexamine whether DNA adducts of ... prepare easily and precisely the samples of DNA modiﬁed by the platinum complex at a prese-lected value of rb. The samples of DNA modiﬁed by new platinum compound and analyzed further by bio-physical...

Báo cáo khoa học: A single EF-hand isolated from STIM1 forms dimer in the absence and presence of Ca2+ ppt

... solution contain-ing 30 lm of Tb3+ and 1.5 lm of protein was set as thestarting point. The stock solution of 10–100 mm CaCl2withthe same concentration of Tb3+ and protein was graduallyadded ... afﬁni-ties and metal-binding properties of CaM [14] and other EF-hand proteins, such as the nonstructural pro-tease domain of rubella virus [15]. We have shown thatan isolated EF-hand loop without ... the oligomeric state of the EF-hand of STIM1using size-exclusion chromatography and pulsed-ﬁelddiffusion NMR. We found that mutations on looppositions 1 and 3 of the EF-hand from STIM1decreased...

Báo cáo y học: "MALDI-TOF MS Combined With Magnetic Beads for Detecting Serum Protein Biomarkers and Establishment of Boosting Decision Tree Model for Diagnosis of Colorectal Cancer"

... The protein profile of the serum samples from the 98 patients with CRC and the 80 healthy controls were extracted by magnetic beads and examined by MALDI-TOF-MS. The data were analyzed by Bio-marker ... proteome profiles of CRC were generated by using the combination of MALDI-TOF MS and WCX magnetic beads as well as pattern recognition soft-ware in our study. The 68 different protein peaks ... mixtures of proteins. Captured proteins are then analyzed by TOF-MS, generating a spectral map depicting approximations of the molecular weight (m/z) and relative concentration (intensity) of each...

Báo cáo khoa học: Spermosin, a trypsin-like protease from ascidian sperm cDNA cloning, protein structures and functional analysis doc

... The presence of two forms of spermosin in H. roretzi sperm. (A)SDS/PAGE of the puri®ed spermosin. SDS/PAGE gave a band of 28 kDa under red ucing conditions and two b ands of 33 and 40 kDaunder ... showed twobands of 33 and 4 0 kDa under nonreducing c onditions(Fig. 3A). The N-terminal sequence determination of thesebands (Fig. 3B) revealed that the 28-kDa protein is the heavychain of spermosin, ... amino-acid seq uences of three bands. T he 28-kDa protein had a single amino-acid sequence and was determined as a heavy chain of spermosin, whereas the 40-kD a protein con siste d of a he avy chain(residues...

Báo cáo khoa học: Differential post-translational modiﬁcation of CD63 molecules during maturation of human dendritic cells potx

... bothimmature and mature dendritic cells, the amount of the34 kDa form of CD63 disappeared gradually during thechase period, concomitantly with the appearance of isoforms of CD63 of  50 and  70 ... maturation of dendritic cells, the number of MHCclass II-peptide complexes that are generated is increased,both by a transient up-regulation of synthesis as well as by an increase in half-life of MHC ... kDa protein, the molecular mass of which increasedto  70 kDa after maturation of the cells induced by LPS(Fig. 1A, lane 2 and 4). The increase in molecular mass of CD63 was independent of the...

Báo cáo khoa học: "Recognition of the Coherence Relation between Te-linked Clauses" potx

... (Hovy and Maier, 1993) for a survey). However, the definitions are rather vague and they are often recognized to be underspecified (Moore and Pollack, 1992; Fukumoto and Tsujii, 1994). This ... manner of event are also contained in this category, since a manner accompanies an event. The notion of the manner is continuous to the means since the means and manner of an event are often ... the means of an event often determines the manner of the event. This is exem- plified by English with as well as Japanese de, which are used both as an instrumental or means marker and as a...

Báo cáo khoa học: "RECOGNITION OF LINEAR CONTEXT-FREE REWRITING SYSTEMS*" ppt

... derived by G only in two possible ways and only by using the first string components of a set of nonterminals N(0 of fan-out two. In this way the derivation of the substring w(X)w(2) w(p) by ... Outline of the proof. Let (U, C) be an arbitrary in- stance ofthe 3SAT problem, where U = {Ul, , up} is a set of variables and C = {Cl, c,} is a set of clauses; each clause in C is represented by ... paper. A full discussion of some interesting implications for recognition and parsing is deferred to Section 3. Due to the scope of the paper, proofs of Theorems 1 and 2 below are not carried...

Tài liệu Báo cáo khoa học: Paradoxical interactions between modiﬁers and elastase-2 Patricia Schenker and Antonio Baici docx

... inhibition of elastase-2 by a1-PI and interference by sulfated polysaccharides.Fig. S2. Progress curves for the inhibition of elastase-2 by eglin c and interference by sulfated polysaccharides. This ... inhibition and reactivation by the con-comitant action of two modiﬁers I and X. Plots of the reaction rateas a function of the concentration (mM) of two modiﬁers. Thekinetic parameters and coefﬁcients ... orpresence of effectors, not to determine absolute valuesfrom their dependence on the concentration of eglin c and a1-PI. The effects of inhibition by a1-PI and eglin c by Ch4S, calculated by regression...

Tài liệu Báo cáo khoa học: Experimental proof for a signal peptidase I like activity in Mycoplasma pneumoniae, but absence of a gene encoding a conserved bacterial type I SPase pdf

... Absence of these proteins causes arandom insertion of the P1 protein and a cytadher-ence-negative phenotype [13]. P1 is encoded by MPN141 and both, P40 and P90 by MPN142. Thesegenes are organized, ... insight into the function of this protein com-plex, the subunits had to be characterized in detail.The N-terminal end of P90 was determined by Edmandegradation. This protein begins with an arginine ... theamino terminus of this peptide, as read from the genesequence, then this peptide is taken as the N-terminalpeptide of this protein [27]. This is, however, not anexact proof, as such a cleavage...

Tài liệu Báo cáo khoa học: Enlarging the gas access channel to the active site renders the regulatory hydrogenase HupUV of Rhodobacter capsulatus O2 sensitive without affecting its transductory activity docx

... eutropha was shown to be verysimilar to that of standard hydrogenases, with a Featom liganded by 1 CO and 2 CN–[16], and the binding of an hydride to Ni and Fe after H2reduction hasrecently ... inactivation by air. The hydrogenase activity of the puriﬁed proteins,assayed by H2uptake in the presence of benzyl violo-gen, was about ﬁvefold lower in the mutant protein OD7 than that of wild-type ... viologenÆmin)1Æ(mg protein) )1). Tocheck the stability of the proteins in the presence of O2, soluble extracts and puriﬁed proteins were storedin air at 4 °C for several days, and, each day,H2-uptake...

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