Báo cáo khoa học: Pyruvate metabolism in rat liver mitochondria What is optimized at steady state? pptx

... Urbanczik Pyruvate metabolism in rat liver mitochondria FEBS Journal 272 (2005) 6244–6253 ª 2005 FEBS No claim to original US government works 6253 Pyruvate metabolism in rat liver mitochondria What is ... Oxaloacetate + H 2 O fi Citrate + CoASH Citrate synthase 2.3.3.1. 7 Pyruvate + ATP + CO 2 fi Oxaloacetate + ADP + P i Pyruvate carboxylase 6.4.1.1. 8 Citrate fi...

Ngày tải lên: 16/03/2014, 14:20

... than in liver mitochondria) owing to a defect in the transformation of citrate into 2-oxogluta- rate (i.e. failure in both aconitase and isocitrate dehydrogenase activities), which induces citrate ... remains to be determined. For instance, in AS-30D and HeLa cells, the rate of respiration was 85–90% sensitive to oligomycin, a specific ATP syn- thase inhibitor, indicating that the r...

Ngày tải lên: 30/03/2014, 09:20

... wild-type protein at 0 h). Nevertheless, it could also be explained by changes in translation or maturation of the protein. An increase was also observed in the rate of degradation of the remaining mutant ... after incubation with [ 35 S]methionine may indicate an alteration in the rate of its degradation during the labeling period. In fact, only 15% of 35 S-labeled mutant protein r...

Ngày tải lên: 20/02/2014, 03:20

... domain put their dependents in a com- mon pot. In other words, there is no scram- bling in German, or more precisely, there is no advantage in assuming an operation that de- rives ‘scrambled’ sentences ... of communi- cative type: In (2a), the fact of reading the book is marked (as in Reading the book, no- body promised him that), whereas (2b) is neu- tral in this respec...

Ngày tải lên: 20/02/2014, 18:20

... role because it stimulates integration of LHCP into the membrane in a mechanism that is independent of the DpH [6]. Intriguingly, some interesting phenotypes have emerged in studies on cpSRP mutants. ... prerequisite to Tat transport, folding is not required for translocation of Tat substrates in chlorop- lasts [18]. Figure 1 summarizes the differing mecha- nisms of the Sec and Tat...

Ngày tải lên: 07/03/2014, 03:20

... asymmetry between nominalisation and ver- balisation in Chinese was observed in Tai (1997). 116 In other words, verbs are more freely deverbal- ised than nouns denominalised. This fluidity be- tween ... There is no one-to-one relationship between grammatical function and syntactic category. As in (3), the word Ca (sing) is the predicate in (a) but is the modifier in (b). (3)...

Ngày tải lên: 08/03/2014, 21:20

... compilation ª 2008 FEBS amplitude of the oscillation. Inherent in many of the starting points for analysis of microarray data is the idea that the underlying process involves cells that exist at ... maximums in expression at differing phases, it is the collective copy number that is critical to sustained oscillations [38–40]. What s next? What is needed? As impressive as th...

Ngày tải lên: 30/03/2014, 04:20

... whereas pyruvate exacerbated, inactivation induced by short-term saturating O 2 exposure. Superoxide dismutase was more effective than catalase in preventing the inactivation, indicating that reactive ... were incubated in O 2 -saturated buffer on ice, and samples were withdrawn at different times to determine PFOR activity at 37 °C. For reactivation, the sample was incubated in O...

Ngày tải lên: 15/03/2014, 23:20

... propose that pathology data will, in most cases, be more insightful than clinical data in defining the disease. This is based on what we have learned from other neurodegenerative diseases with inclusion ... calcium-independent phospholipase A 2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting cera- mide generation via hydrolysis of sphingomyelins by neut...

Ngày tải lên: 18/02/2014, 14:20

... supplementation. Together, these data indicate that pyruvate is a precursor of glutathione under normoxic conditions through glutamate generated by oxidative metabolism (Fig. 6). However, pyruvate ... 19%, data not shown). This is in line with our previous work [29] indicating enhancement of glycolysis activity in the presence of pyruvate. Increased glycolysis might thus mainta...

Ngày tải lên: 18/02/2014, 16:20