Báo cáo khoa học: Differing molecular mechanisms appear to underlie early toxicity of prefibrillar HypF-N aggregates to different cell types potx

... Authors Journal compilation ª 2006 FEBS Differing molecular mechanisms appear to underlie early toxicity of prefibrillar HypF-N aggregates to different cell types Cristina Cecchi 1 , Anna Pensalfini 1 , ... M & Stefani M (2005) Insights into the molecular basis of the differing susceptibility of varying cell types to the toxicity of amyloid...

Ngày tải lên: 16/03/2014, 13:20

... Beijing, China 2 National Laboratory of Biomacromolecules, Institute of Biophysics (IBP), Chinese Academy of Sciences, Beijing, China Mitochondria are cellular organelles of prokaryotic origin that ... succinate to the ubiquinone pool. Complex III (cytochrome bc 1 complex) delivers electrons from ubiquinone to cytochrome c. It cou- ples this redox reaction to the generation of...

Ngày tải lên: 19/02/2014, 02:20

... been recognized to be fac ilitated by the b inding to HbO 2 of aniline and some of its derivatives, causing distortion of the iron-oxygen bond to s uch an extent as to accelerate autoxidation b ... presence of appropriate metal ions and a source of dioxygen [226]. Although iron appears to b e the most effective BLM cofactor, other metals also bind strongly to the antibio...

Ngày tải lên: 19/02/2014, 16:20

... bottom of the depression on the surface of ALP I, and it was adjacent to Lys26, which was the last residue of N-terminal region on the molecular surface. As a result of substitution of Asp117 to ... Prof Takeshi Uozumi of the Department of Biotechnology, Tokyo University, for the permission to use B. subtilis KN2, and Prof Koji Takahashi of the Department of Applied...

Ngày tải lên: 21/02/2014, 03:20

... Manchester, UK) directly coupled to a Q-TOF hybrid tandem mass spectrometer (QTOF Premier; Waters). 100 % 0 200 400 600 800 1000 1200 1400 1600 1800 2000 2200 m/z TOF MSMS 707.05ES + 7.19e4 b17 1684.04 y''14 1479.81 b14 1353.86 y''15 1592.91 y''18 1836.04 y''13 1422.68 y''17 1748.99 [M+H + ] 2119.21 y''19 1949.13 b20 1941.18 y&apos...

Ngày tải lên: 15/03/2014, 10:20

... of water ⁄ weight of protein). The ability of organic solvents to ‘strip off’ water from the enzyme surface was clearly dependent on the nature of the organic solvent. The rmsd of the enzyme from ... suggests that, to obtain the same amount of water bound to the enzyme, we need to add more water to the system as we move to more polar solvents. The general trend for the...

Ngày tải lên: 16/03/2014, 10:20

... and an intact cytoskeleton [18]. Production of red blood cell ghosts by hypotonic lysis results in the formation of a large number of pores in the red cell membrane, estimated to be 30 nm in diameter ... nature of molecular chaperones and suggests that protection of Na/K-ATPase is ubiquitous to all cells, not just red cell membranes. Heat stress in NIH3T3 cells causes a...

Ngày tải lên: 17/03/2014, 03:20

... support’. An observer’s primal reaction to the vibrant external appearance of a body supported in an intensive care unit (ICU) is radically different from that to a corpse on a morgue slab [9]. As ... terminally ill: the ‘risk of unacceptable badness’ David Crippen Associate Professor, Director, Neurovascular ICU, Department of Critical Care Medicine, University of Pittsburgh Me...

Ngày tải lên: 25/10/2012, 10:45

... ganglion cells might contribute to providing chromophore to melanopsin to maintain their light sensitivities. The expression and function of RPE65c in other cell types in the retina remains to be investigated. Earlier ... 11cRAL to cone photoreceptors in cone-dominant species. Identification of an alterna- tive visual cycle will contribute to the understanding of the func...

Ngày tải lên: 14/02/2014, 14:20

... 1–196) of BTK fused with the linker B kinase region of SYK (306–635 amino acids) (Fig. 2). We used two different cell types to study the phosphorylation status of key residues and the capacity to ... the B -cell lineage of these animals, it did not induce the formation of B -cell lymphomas. Thus, transgenic mice with a CD19 promoter-mediated expression of ITK–SYK faile...

Ngày tải lên: 14/02/2014, 18:20