Báo cáo khoa học: Roles of base excision repair subpathways in correcting oxidized abasic sites in DNA pptx

... BER of oxidized abasic sites FEBS Journal 273 (2006) 1620–1629 ª 2006 The Authors Journal compilation ª 2006 FEBS 1629 MINIREVIEW Roles of base excision repair subpathways in correcting oxidized ... well-characterized DNA base modification is uracil, which can arise in genomic DNA by misincorporation of dUMP during DNA syn- thesis, or by the spontaneous de...

Ngày tải lên: 16/03/2014, 13:20

... helix–span–helix domain at the C-terminus shown in blue medi- ates dimerization and, together with the basic domain, (red) DNA- binding. ‘*’, amino acids that are identical in all sequences in the align- ment; ... role of AP-2a and AP-2e in chondrogenesis. Overview of the differen- tiation stages during chondrogenesis and the involvement of transcription factors (henatoxylin an...

Ngày tải lên: 16/02/2014, 09:20

... section and scheme of the coronal section at E14.5 in (F). (A) At E11.5, HSF2 is expressed in forebrain, midbrain and in hindbrain except for the midbrain, hindbrain midline. Surprisingly, the HSF2 ... identified in famil- ial cases of cataracts. Interestingly, mutations in the DNA- binding domain seem to be associated with dom- inant cataracts, whereas mutations within (or down...

Ngày tải lên: 18/02/2014, 04:20

... HsRad51 to examine whether these loops are actually involved in DNA binding. Because aromatic residues are involved in the ssDNA binding by bacterial single stranded DNA- binding protein (SSB) and ... the DNA- binding site. The fluorescence change upon DNA binding is not strong enough for a stacking interaction of the residue with a DNA base, but is large enough to indicate DNA...

Ngày tải lên: 19/02/2014, 06:20

... these three arginines in TClpB. By combining an arginine mutation with the WalkerA mutation in the other AAA+ module, we tested the roles of the arginines in ATP binding and hydrolysis in each module. ... of the hexameric form, but not for the ATP-induced motion of the middle domain. Results The conserved arginines are not involved in nucleotide binding To examine the roles...

Ngày tải lên: 06/03/2014, 00:20

... application of SH2 domain binding peptides, which results in blocking of the binding of the SH2 domain to the substrate and thereby preventing interaction of the substrate with the kinase domain. For ... demonstrated that intra-domain interactions between Src family kinases (SFKs), stabilized by binding of the phosphorylated C-terminus to the SH2 domain and ⁄ or binding of the S...

Ngày tải lên: 06/03/2014, 01:20

... that only a trace of the pro- tein was left in the unbound fraction. Pre-incubation of the recombinant protein with FP abolished most of this binding, suggesting that binding of rPf1-Cys-Prx to ... parasite against the oxidative stresses resulting from metabolism of haemoglobin. This may occur in multiple steps: binding to FP, slow- ing GSH-mediated FP degradation in a competi...

Ngày tải lên: 07/03/2014, 17:20

... their main roles focus on ectodomain shedding and nonpro- teolytic functions, such as binding to adhesion mole- cules, integrins and interacting with phosphorylation sites for serine ⁄ threonine ... than one-third of all solid tumors [20]. During cancer progression, increased shedding of the membrane-anchored ligands of EGFR, including heparin-binding EGF (HB-EGF), transforming grow...

Ngày tải lên: 15/03/2014, 00:20

... structure of the diol dehydratase–adeninylpentylcobalamin com- plex revealed that the adenine moiety of adenosylcobalamin is anchored in the adenine-binding pocket of the enzyme by hydrogen bonding of ... ade- ninylpentylcobalamin (AdePeCbl), an inactive coen- zyme analog, revealed the presence of the adenine- binding pocket in the active site of the enzyme [21] (Fig. 1A). The...

Ngày tải lên: 23/03/2014, 06:20

... treatments in rats: evidence for central oxytocin inhibition of food intake. Endocri- nology 129, 785–791. 18 Blevins JE, Eakin TJ, Murphy JA, Schwartz MW & Baskin DG (2003) Oxytocin innervation of ... impli- cated in a variety of roles, including energy metabolism, stress and pain modulation, as well as effects in the neuroendocrine and cardiovascular systems. In the prese...

Ngày tải lên: 29/03/2014, 21:20