Báo cáo khoa học: Coiled–coil interactions modulate multimerization, mitochondrial binding and kinase activity of myotonic dystrophy protein kinase splice isoforms pptx

... Journal compilation ª 2006 FEBS Coiled–coil interactions modulate multimerization, mitochondrial binding and kinase activity of myotonic dystrophy protein kinase splice isoforms Rene ´ E. M. A. van ... domain modulates myotonic dystrophy protein kinase multimerization, substrate binding, kinase activity and subcellular localization characterist...

Ngày tải lên: 16/03/2014, 13:20

... initial molecu- lar activity of Sry is translated into cellular structure and organ morphology. Interestingly, Dmrt1, the ancestor of Dmrt1bY, is one of the downstream effec- tors of Sry in the male ... prototype members of this group of factors are the Drosophila doublesex (dsx) and Caenor- habditis mab-3 genes. The Dmrt group of molecules is characterized by a conserved...

Ngày tải lên: 14/02/2014, 19:20

... effector of TetR known so far. The DNA fragments containing the randomized codons 14–25 (C-terminal part of helix a1 and the following loop) and 93–102 (helix a6 and the b-turns N-terminal and C-terminal ... a4 and 3900 out of the helix a6 pool and obtained a total of 15 candidates with the desired properties. These were confirmed by in vivo repression and induction deter...

Ngày tải lên: 20/02/2014, 01:20

... possible modifyees of “keisatsu-de” are “arui- teiru” and “hogo-shita”. Taking into account in- formation about the co-occurrence of “keisatsu- de” and “arui-teiru” and of “keisatsu-de” and “hogo-shita” ... probability of the case element set (bunsetsu set) and the co- occurrence probability of the particle set, and we select the ˆ T that maximizes the probability. Some...

Ngày tải lên: 20/02/2014, 12:20

... is due to CatD, and the decrease in activity can be assigned to CatE. The activity of CatE and CatD in cytosolic, endosomal and lysosomal fractions of B cells, dendritic cells and human keratinocytes ... on CatD activity (Fig. 4B). This approach for depleting proteinase activity from complex biological samples is flexible and can be used for other proteinases as well. Ac...

Ngày tải lên: 07/03/2014, 09:20

... relevant to this binding. Some of these Fig. 10. Prediction of nucleolin -binding sites in human lactoferrin (hLf). Sequences of the N2 and C2 domains of hLf, bovine lactoferrin (bLf) and human transferrin ... Properties of the iron -binding site of the N-terminal lobe of human and bovine lactotransferrins. Importance of the glycan moiety and of the non-covalent...

Ngày tải lên: 07/03/2014, 15:20

... Distributions of TSC1 and TSC2 proteins in the membrane fraction and the cytosolic fraction. Alterations in the relative amounts of both TSC1 and TSC2 proteins were quantified as a percentage of control ... a small G protein. The GTP-bound active form of Rheb strongly stimulates mTOR and its downstream targets, such as the ribosomal S6 kinase 1 (S6K1) and the eukaryotic in...

Ngày tải lên: 15/03/2014, 11:20

... classes of endings: andare (to go), for example, admits two different stems, vad (go) and and (went); so there exist two subclasses of endings named respectively dvl andare and dr2 andare. ... prep.simple 2 andare vad dv 1 _andare v.intran.simple 1 andare and I dv2. andar© v.intran.simple I The other sets of data are contained in the Prolog workspace and are struct...

Ngày tải lên: 24/03/2014, 05:21

... of reduction of the FMN cofactor was very small, amounting to 0.6% and 3% of the wild-type rate for the D137L and K109L ⁄ D137L protein variants, respectively. The rate of reduction for the other two protein ... with binding of NADPH and ⁄ or delivery of a hydride to the flavin cofacor and hence K109 plays a dual role by supporting tetramer assembly through its intera...

Ngày tải lên: 30/03/2014, 01:20

... the exposure of hydrophobic regions during the urea- induced unfolding of W243 mutants compared with the wild-type DAAO. Kinetics of reconstitution of apoprotein with FAD Because of the weaker binding of ... FAD cofactor to the apoprotein of the W243 mutants, we studied the kinetics of reconstitution of the apoprotein–FAD com- plexes under pseudo-first-order conditions (10-...

Ngày tải lên: 30/03/2014, 11:20