Báo cáo khoa học: a-Conotoxin analogs with additional positive charge show increased selectivity towards Torpedo californicaand some neuronal subtypes of nicotinic acetylcholine receptors pdf

... results show that introduction of a positive charge to the C-terminus of a-conotoxins gives new analogs of distinct selectivity whose mode of action, with the purpose of future design of novel antagonists, ... Novel a-conotoxin analogs FEBS Journal 273 (2006) 4470–4481 ª 2006 The Authors Journal compilation ª 2006 FEBS 4481 a-Conotoxin analogs with additiona...

Ngày tải lên: 16/03/2014, 13:20

... C d1 methyl of the Ile50 side chain forms C-HÆÆÆO interactions with the hydroxyl oxygen of Thr80¢ and carbonyl oxygen of Pro79¢, and the C d1 of Ile50¢ interacts with the hydroxyl of Thr80. Mutation ... These lines of evidence, taken together, strengthen the suggestion that loss of the C-HÆÆÆO interaction of residue 50 with the hydroxyl of Thr80, as well as loss of h...

Ngày tải lên: 18/02/2014, 04:20

... mutants showed a very different dependence on l-dopa as cofactor to eliminate the characteristic lag period of tyrosinases [8,20,21]. Figure 3 shows the rate of TH activity as a function of the ... copper-binding histidines of the two PPOs do not show any differences (Table 1), but some distinctions must exist. The most reliable way of exploring this is comparison of crystal s...

Ngày tải lên: 19/02/2014, 07:20

... percentage of sentences with correct answers), as well as F1: the harmonic mean of precision (the proportion of correct answers out of sentences with a parse) and recall (the proportion of correct ... i th child of the parent produced by rule m. Aside from ensuring the grammaticality of the generated MR, rules of this type also model the probability of the MR, con- ditio...

Ngày tải lên: 19/02/2014, 19:20

... decreased as a result of em- ploying the SRH. We show the performance of GIZA++ and HM- BiTAM with the SRH in the lines entitled with SRH” in Table 1. The GIZA++ and HM-BiTAM with the SRH slightly ... 21872 30294 with SRH 9737 20077 27970 Table 2: The number of vocabularies in the 10k, 50k and 100k data sets. were replaced with the word ‘sick’. As shown in Table 2, the number...

Ngày tải lên: 20/02/2014, 04:20

... implementation of the basic ar- chitecture of contemporary state -of- the-art coref- erence systems and a variety of individual mod- ules employed in these systems. Additionally, Reconcile handles all of the ... Reconcile, that can serve as a software infrastructure to sup- port the creation of, experimentation with, and evaluation of coreference resolvers. Reconcile was designed...

Ngày tải lên: 20/02/2014, 04:20

... 1188 1189 Proceedings of the 49th Annual Meeting of the Association for Computational Linguistics, pages 1179–1189, Portland, Oregon,

Ngày tải lên: 20/02/2014, 04:20

Ngày tải lên: 20/02/2014, 18:20

... shifts of attention, we seek a formalisation of the information structure of utterances in terms of the new information that is exchanged in the course of the dialogue. The purpose of our ... the erroneous analyses of the initial speech input. 1 The output of a speech recognizer has direct influence on the performance of other mod- ules of the system (dealing wit...

Ngày tải lên: 20/02/2014, 18:20

... that make many of them suspect. One of the key advantages of ROC is that it provides a clear indication of chance level performance as well as a less well known indication of the relative ... we focus on the Kappa family of measures, as well as some closely related statistics named for other letters of the Greek alphabet, and some measures that we will show behave a...

Ngày tải lên: 22/02/2014, 02:20