Báo cáo khoa học: Bistability from double phosphorylation in signal transduction Kinetic and structural requirements potx

... K S1 and q is displayed in Fig. 4, showing that two regions can be defined in the space of kinetic parameters (q, K S1 ), one resulting in bistable behavior and the other resulting in a single ... that some individual signaling ele- ments are doubly modified proteins and the enzymes catalyzing these modifications follow a particular set of kinetic requirements. Therefore, the...

Ngày tải lên: 16/03/2014, 13:20

... MPK3 and MPK6 in Arabidopsis (group A MAPKs), SIMK and SAMK in alfalfa, and LeMPK1 ⁄ 2(Lycopersicon esculentum SA-induced pro- tein kinase) and LeMPK3 (L. esculentum wound- induced protein kinase) ... protein kinase and wound- induced protein kinase, two MAPKs in group A, were activated by inoculation with the tobacco mosaic virus (TMV) [10]. Their orthologs in other plant s...

Ngày tải lên: 14/03/2014, 23:20

... death, including the mitogen-activated protein kinase signal transduction pathways. Reversible protein phosphorylation is involved in the widespread regulation of cellular signal transduction and ... cytochrome c from mitochon- dria into the cytosol through inactivation with Bcl-xL and Bcl-2 [69]. Inactivated Bax and Bad bind 14-3-3, the phosphoserine ⁄ threonine binding p...

Ngày tải lên: 14/02/2014, 22:20

... urochordate C. intestinalis and the echinoderm S. purpuratus; and in protostome invertebrates, the mollusk Aplysia californica and vari- ous nematodes, including Caenorhabditis elegans, sug- gesting that ... cysteine residues involved in intrachain disulfide bonding in AChEs are found in the sequence, only two members of the catalytic triad are present: serine and glutamate. Th...

Ngày tải lên: 18/02/2014, 17:20

... YO. To investigate the initial stages of signal transduction, i.e. receptor binding, we determined receptor number (B max ) and affinity (K d ) of binding sites in membrane preparations of YO obtained ... individually measured and analyzed by ANOVA showed highly significant pairing in peptide contents between sinus glands from individuals, thus demonstrating that each SG from ind...

Ngày tải lên: 21/02/2014, 00:20

... string in Right, or more precisely a string in Right where additional instances of rb2 are freely inserted in any position other than the beginning. This ex- pression is written as: intro ... freely introduce marker symbols into a string at any po- sition except the beginning or the end. %% Free introduction macro(intro(S) ,{xsig-S, [] x S}*) . ~.7. Introduction, except at b...

Ngày tải lên: 22/02/2014, 03:20

... arginines in TClpB. By combining an arginine mutation with the WalkerA mutation in the other AAA+ module, we tested the roles of the arginines in ATP binding and hydrolysis in each module. The arginine ... exam- ine the roles of the conserved arginines, Arg322 (P2) and Arg323 (P1) of AAA-1, and Ar g747 (P1) of AAA- 2, and determined that the arginines of TClpB are not involved...

Ngày tải lên: 06/03/2014, 00:20

... 10% fetal bovine serum, 0.5 mm isobutylmethylxanthine, 1 lm dexa- methasone and 1.7 lm insulin (days 3 and 4). Cells were then maintained in fetal bovine serum ⁄ DMEM with 1.7 lm insulin for another ... for each ligand tested while keeping protein side chains fixed, and these were sorted in ascending order according to their total energy. Binding modes with the lowest total energies...

Ngày tải lên: 06/03/2014, 09:22

... using a gamma counter (LKB, Wallac, Finland). All animals were maintained and handled according to local and national ethical guidelines. Animal model of septic shock Two groups, each containing ... worldwide [1]. Ixodes ricinus is widely found in Europe and is able to take its blood meal from a variety of verte- brates, ranging from amphibians to mammals, and including domestic...

Ngày tải lên: 07/03/2014, 01:20

... Processing. To Appear. Alexander Fraser. 2009. Experiments in morphosyn- tactic processing for translating to and from German. In Proceedings of the Fourth Workshop on Statis- tical Machine Translation, ... Proceedings of International Conference on New Methods in Lan- guage Processing. Kristina Toutanova, Dan Klein, Christopher D. Man- ning, and Yoram Singer. 2003. Feature-rich p...

Ngày tải lên: 07/03/2014, 22:20